Results 31 to 40 of about 633,370 (307)

Whole blood flow cytometry protocol for the assessment of platelet phenotype, function, and cellular interactions

Platelets, 2021
Platelets are a key component of the hemostatic system and their roles in inflammation via interactions with leukocytes have also gained attention in recent years.
Hui Ping Yaw, Suelyn Van Den Helm, Matthew Linden, Paul Monagle, Vera Ignjatovic   +4 more
doaj   +1 more source

Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Vascular function is compromised in Alzheimer disease (AD) years before amyloid and tau pathology are detected and a substantial body of work shows abnormal platelet activation states in patients with AD.
Jaime Ramos‐Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Nunzio Pomara, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio   +17 more
doaj   +1 more source

Identification of a pathogenic TUBB1 variant in a Chinese family with congenital macrothrombocytopenia through whole genome sequencing

Platelets, 2021
Congenital macrothrombocytopenia is a genetically heterogeneous group of rare disorders. We herein report a large Chinese family presented with phenotypic variability involving thrombocytopenia and/or giant platelets. Whole genome sequencing (WGS) of the
Yu Hou, Linlin Shao, Hai Zhou, Yanfeng Liu, Dianna G. Fisk, Elizabeth Spiteri, James L. Zehnder, Jun Peng, Bing M. Zhang, Ming Hou   +9 more
doaj   +1 more source

Normal platelet function [PDF]

Cancer and Metastasis Reviews, 2017
Platelets play an important role in the vessel. Following their formation from megakaryocytes, platelets exist in circulation for 5-7 days and primarily function as regulators of hemostasis and thrombosis. Following vascular insult or injury, platelets become activated in the blood resulting in adhesion to the exposed extracellular matrix underlying ...
openaire   +2 more sources

The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function [PDF]

, 2011
Background: Thiol isomerases are a family of endoplasmic reticulum enzymes which orchestrate redox-based modifications of protein disulphide bonds. Previous studies have identified important roles for the thiol isomerases PDI and ERp5 in the regulation ...
Bicknell, Andrew B., Gibbins, Jonathan M., Holbrook, Lisa-Marie, Sasikumar, Parvathy, Simmonds, Alan D., Stanley, Ronald G.   +5 more
core   +1 more source

Flow cytometry for evaluating platelet immunophenotyping and function in patients with thrombocytopenia

Tzu Chi Medical Journal, 2022
Platelets play an essential role in primary hemostasis through bleeding and thromboembolism. Thus, the diagnosis or evaluation of impaired hereditary, acquired, and drug-related platelet dysfunction has become imperative.
Chih-Lung Shen, Yi-Feng Wu
doaj   +1 more source

Evidence of platelet activation in multiple sclerosis [PDF]

, 2008
Objective A fatality in one multiple sclerosis (MS) patient due to acute idiopathic thrombocytopenic purpura (ITP) and a near fatality in another stimulated our interest in platelet function abnormalities in MS.
Sheremata, William A, Jy, Wenche, Horstman, Lawrence L, Ahn, Yeon S, Alexander, J Steven, Minagar, Alireza   +5 more
core   +2 more sources

The association of P2Y12 inhibitors with pro-coagulatory extracellular vesicles and microRNAs in stable coronary artery disease

Platelets, 2020
Extracellular vesicles (EV) act as a cellular communication tool by carrying lipids, proteins and micro RNA (miR) between cells, thereby playing a pivotal role in thromboembolic processes.
Paul M Haller, Stefan Stojkovic, Edita Piackova, Tijana Andric, Lukas Wisgrill, Andreas Spittler, Johann Wojta, Kurt Huber, Bernhard Jäger   +8 more
doaj   +1 more source

Relation of Level of Platelet Inhibition after Eptifibatide with Major Cardiovascular Events in ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Majalah Kardiologi Indonesia, 2015
Background: Eptifibatide, an inhibitor of glycoprotein IIb/IIIa administered as adjunctive therapy to reperfusion therapy Primary PCI in STEMI patients.
Elisa Feriyanti Pakpahan, Sunarya Soerianata, Nur Haryono   +2 more
doaj   +1 more source

Improvement of human platelet aggregation post-splenectomy with paraesophagogastric devascularization in chronic hepatitis B patients with cirrhotic hypersplenism

Platelets, 2020
Thrombocytopenia is a common hematological abnormality in patients with cirrhotic hypersplenism. Splenectomy with paraesophagogastric devascularization (SPD) is a conventional surgical therapy which can reverse pancytopenia in these patients.
Hui Zhang, Shaoying Zhang, Jian Zhang, Rui Zhou, Yongzhan Nie, Song Ren, Jun Li, Keping Feng, Fanpu Ji, Guangyao Kong, Zongfang Li   +10 more
doaj   +1 more source