Results 21 to 30 of about 5,714,223 (293)

Platelet function and platelet lipid composition in the dyslipoproteinemias

Journal of Lipid Research, 1980
Blood platelets from eight patients with hyperbetalipoproteinemia (type II) were more reactive to aggregating agents in vitro than those of 13 type IV patients or 12 normal subjects. Platelets of two patients with abeta-lipoproteinemia were also slightly
K M Shastri, A C Carvalho, R S Lees
doaj   +1 more source

Harmonizing light transmission aggregometry in the Netherlands by implementation of the SSC-ISTH guideline

Platelets, 2021
Light transmission aggregometry (LTA) is considered the gold standard method for evaluation of platelet function. However, there are a lot of variation in protocols (pre-analytical procedures and agonist concentrations) and results.
I.C.A. Munnix, R. Van Oerle, P. Verhezen, P. Kuijper, C.M. Hackeng, H.I.J. Hopman-Kerkhoff, F. Hudig, D. Van De Kerkhof, A. Leyte, M.P.M. De Maat, R.F.M. Oude Elferink, J. Ruinemans-Koerts, M. Schoorl, J. Slomp, H. Soons, A. Stroobants, E. Van Wijk, Y.M.C. Henskens   +17 more
doaj   +1 more source

Platelet count and function in umbilical cord blood versus peripheral blood in term neonates

Platelets, 2021
Platelet function in neonates is sparsely investigated. The majority of previous studies investigated platelets in umbilical cord (UC) blood rather than in peripheral blood. We included 20 term neonates and sampled UC blood and peripheral blood within 20 
Alexander K. Grevsen, Claus V. B. Hviid, Anne K. Hansen, Anne-Mette Hvas   +3 more
doaj   +1 more source

Expression of ADP receptor P2Y12, thromboxane A2 receptor and C-type lectin-like receptor 2 in cord blood-derived megakaryopoiesis

Platelets, 2021
The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis.
Catharina Gerhards, Stefanie Uhlig, Mani Etemad, Foteini Christodoulou, Karen Bieback, Harald Klüter, Peter Bugert   +6 more
doaj   +1 more source

Whole blood flow cytometry protocol for the assessment of platelet phenotype, function, and cellular interactions

Platelets, 2021
Platelets are a key component of the hemostatic system and their roles in inflammation via interactions with leukocytes have also gained attention in recent years.
Hui Ping Yaw, Suelyn Van Den Helm, Matthew Linden, Paul Monagle, Vera Ignjatovic   +4 more
doaj   +1 more source

Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Vascular function is compromised in Alzheimer disease (AD) years before amyloid and tau pathology are detected and a substantial body of work shows abnormal platelet activation states in patients with AD.
Jaime Ramos‐Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Nunzio Pomara, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio   +17 more
doaj   +1 more source

Identification of a pathogenic TUBB1 variant in a Chinese family with congenital macrothrombocytopenia through whole genome sequencing

Platelets, 2021
Congenital macrothrombocytopenia is a genetically heterogeneous group of rare disorders. We herein report a large Chinese family presented with phenotypic variability involving thrombocytopenia and/or giant platelets. Whole genome sequencing (WGS) of the
Yu Hou, Linlin Shao, Hai Zhou, Yanfeng Liu, Dianna G. Fisk, Elizabeth Spiteri, James L. Zehnder, Jun Peng, Bing M. Zhang, Ming Hou   +9 more
doaj   +1 more source

Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway [PDF]

, 2013
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Voahanginirina Randriamboavonjy, Ingrid Fleming, Amro Elgheznawy, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Amro Elgheznawy (458464), Karin Hadas, Hadas, Karin, Karin Hadas (458462), Alexander Mann (262817), Elgheznawy, Amro, Mann, Alexander, Ingrid Fleming (132865), Alexander Mann, Voahanginirina Randriamboavonjy (458463)   +14 more
core   +1 more source

Relation of Level of Platelet Inhibition after Eptifibatide with Major Cardiovascular Events in ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Majalah Kardiologi Indonesia, 2015
Background: Eptifibatide, an inhibitor of glycoprotein IIb/IIIa administered as adjunctive therapy to reperfusion therapy Primary PCI in STEMI patients.
Elisa Feriyanti Pakpahan, Sunarya Soerianata, Nur Haryono   +2 more
doaj   +1 more source

Flow cytometry for evaluating platelet immunophenotyping and function in patients with thrombocytopenia

Tzu Chi Medical Journal, 2022
Platelets play an essential role in primary hemostasis through bleeding and thromboembolism. Thus, the diagnosis or evaluation of impaired hereditary, acquired, and drug-related platelet dysfunction has become imperative.
Chih-Lung Shen, Yi-Feng Wu
doaj   +1 more source