Results 291 to 300 of about 1,089,521 (397)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Combined use of anti-platelet aggregation drugs and shujin huoluo decoction for diabetic peripheral vascular disease: enhanced therapeutic efficacy. [PDF]

Am J Transl Res
Li Z, Yu Y, Chen B.
europepmc   +1 more source

Measurement of spontaneous platelet aggregation in patients with acute cerebral infarction using laser-scattered light aggregometry

, 2004
Koji Yamada, Toshikazu Hirayama, Hiroshi Sugihara, Naoko Yazaki, Youichi Takahashi, H Toshima   +5 more
openalex   +2 more sources

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and humans. [PDF]

Mol Med
Ebelt ND, Loganathan S, Avsharian LC, Manuel ER.   +3 more
europepmc   +1 more source

Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study

Titchaphorn Palo, Nalinthika Nathananwanit, Pravit Akarasereenont, Suksalin Booranasubkajorn   +3 more
openalex   +2 more sources

Inhibitory effect of activated protein C on platelet aggregation induced by the prothrombin-converting reaction.

, 1993
Kyoko Inoue, Katsushi Takahashi, Hideki Horiuchi, Keiji Komoriva, Koji Suzuki   +4 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Dihydrogeodin from <i>Fennellia flavipes</i> Modulates Platelet Aggregation via Downregulation of Calcium Signaling, αIIbβ₃ Integrins, MAPK, and PI3K/Akt Pathways. [PDF]

Mar Drugs
Akram AW, Choi DC, Chae HK, Kim SD, Kwak D, Yun BS, Rhee MH.   +6 more
europepmc   +1 more source