Results 281 to 290 of about 237,113 (353)

Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk. [PDF]

open access: yesJ Am Heart Assoc
Kovbasyuk Z   +10 more
europepmc   +1 more source

Profiling Localized Immunomodulation and Drug Biodistribution within a Subcutaneous Vascularized Niche for Cell Transplantation

open access: yesAdvanced Science, EarlyView.
We studied how five common immunosuppressants behave when delivered directly to a transplant site instead of systemically. Using a vascularized implant for islet transplantation, we show that local delivery protects grafts, limits drug spread to the rest of the body, and produces distinct immune signatures.
Jocelyn Nikita Campa‐Carranza   +19 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

open access: yesAdvanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu   +15 more
wiley   +1 more source

Novel Vascular‐Adaptive Liquid Metal Microspheres Enable Visualized Arterial Embolization Therapy

open access: yesAdvanced Science, EarlyView.
We present drug‐loaded liquid metal microspheres (X‐MEN) as a novel agent for image‐guided arterial embolization. With inherent radiopacity and superior deformability, X‐MEN enables real‐time monitoring and conforms tightly to irregular vessels. This approach ensures precise, long‐lasting embolization without recanalization, addressing critical ...
Chenyu Shen   +14 more
wiley   +1 more source

TEG platelet mapping and impedance aggregometry to predict platelet transfusion during cardiopulmonary bypass in pediatric patients [PDF]

open access: yes, 2019
Baltagi, Sirine   +6 more
core   +1 more source

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