Results 291 to 300 of about 218,065 (393)

Engineering ultrapotent trivalent anticoagulants through hybridisation of salivary peptides from multiple haematophagous organisms. [PDF]

Chem Sci
Maxwell JWC, Ripoll-Rozada J, Mackay AS, Alwis I, Ford DJ, Trought CBJ, Santos JA, Smythe RE, Liu JST, Zuccolotto Z, Schoenwaelder SM, Jackson SP, Pereira PJB, Payne RJ.   +13 more
europepmc   +1 more source

Binding of a novel platelet aggregation inhibitor to human platelet actin

Japanese Journal of Pharmacology, 1982
Yukio Kimura, Toshio Tanaka, Hideaki Kohri, Hayato Umekawa, Kozo Watanabe, Hiroyoshi Hidaka   +5 more
openaire   +2 more sources

Assessing Extracellular Vesicle Turnover In Vivo Using Highly Sensitive Phosphatidylserine‐Binding Reagents

Advanced Science, EarlyView.
Extracellular vesicles (EVs) are promising biomarkers, but their heterogeneity limits clinical use. A novel high‐affinity phosphatidylserine (PS)‐binding reagent is introduced that reveals ≈90% of circulating EVs are PS⁺. This enables in vivo tracking, showing rapid EV clearance and retention in spleen immune cells—advancing EV quantification ...
Lavinia Flaskamp, Monica Prechtl, Annkathrin Scheck, Wenbo Hu, Christine Ried, Georg Kislinger, Mikael Simons, Anne B. Krug, Jan Kranich, Thomas Brocker   +9 more
wiley   +1 more source

Platelets and Their Role in Immunity: Formation, Activation and Activity, and Biologically Active Substances in Their Granules and Extracellular Vesicles. [PDF]

Int J Inflam
Tokarz-Deptuła B, Baraniecki Ł, Palma J, Stosik M, Syrenicz A, Kołacz R, Deptuła W.   +6 more
europepmc   +1 more source

Does Re-importation Reduce Price Differences for Prescription Drugs? Lessons from the European Union. [PDF]

Allsbrook, Jennifer, Kyle, Margaret, Schulman, Kevin   +2 more
core   +1 more source

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage‐Derived Stem Cells

Advanced Science, EarlyView.
CDSCs exhibit the potential to differentiate into endothelial cells, vascular pericytes, and osteoblasts. These differentiated cells are capable of secreting additional pro‐hematopoietic cytokines. Furthermore, CDSCs can inhibit apoptosis and reduce DNA damage in injured hematopoietic stem and progenitor cells (HSPCs, including RHSCs and RHPCs), while ...
Rui Dong, Zhiguo Ling, Pengyuan Fan, Debao Li, Jinsong Wang, Wenjiong Shi, Rui Zuo, Runfeng Chen, Xuemin Sun, Lang Xiao, Yushi Ran, Shucheng Huang, Yi Tian, Chao Zhang, Yuzhang Wu, Bing Ni, Yi Zhang   +16 more
wiley   +1 more source

A review of natural compounds to regulate platelet aggregation: molecular mechanism and research advance. [PDF]

Front Pharmacol
Hou Y, Li H, Zhu L, Li Y, Zeng Y, Quan T, Xiang Z, Zhang Y, Bian Y, Wei Y.   +9 more
europepmc   +1 more source

Conductive Microneedles Loaded With Polyphenol‐Engineered Exosomes Reshape Diabetic Neurovascular Niches for Chronic Wound Healing

Advanced Science, EarlyView.
This study establishes a bio‐electroceutical interface by synergizing engineered exosome‐derived biological signals with electroconductive microneedle‐delivered electrical cues, achieving dual‐pathway reprogramming of the diabetic neurovascular niches and accelerating wound healing. Abstract Diabetic wound healing remains a major clinical challenge due
Di Liu, Jingxian Gao, Xueling Wu, Xinxin Hao, Wenxiu Hu, Lu Han   +5 more
wiley   +1 more source

Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway. [PDF]

Front Nutr
Bi X, Huang X, Zhang C, Zhao X, Ma J, Li M, Li X, Zeng B, Li R, Zhang X, Ya F.   +10 more
europepmc   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source