Results 321 to 330 of about 222,697 (389)
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New carbamoylpiperidines as human platelet aggregation inhibitors
Bioorganic & Medicinal Chemistry, 2000A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure-activity analysis of the bis(nipecotamido)aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the ...
Z, Guo +4 more
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Inhibitors of platelet aggregation from onion
Phytochemistry, 1990Abstract Five new sulphur-containing compounds and five diastereoisomers which indicated potent inhibitory efrects for collagen-induced aggregation of human platelets in vitro as well as ADP- or arachidonate-induced aggregation were isolated from onion. All isolated compounds have a 1-(methylsulphinyl)-propyl alkyl (or alkenyl) disulphide skeleton.
Yasujiro Morimitsu, Shunro Kawakishi
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[Imidazole derivatives, platelet aggregation inhibitors].
Annales pharmaceutiques francaises, 1998Study of the platelet aggregation inhibition has shown the efficiency of compounds with imidazole ring alone or fused. All the compounds resulting of the molecular design starting from these structures has an in vitro activity. We have been able to discuss the correlation existing between activities, toxicities and structures with a particular emphasis
N, Sergueeva +3 more
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Inhibitors of “spontaneous” platelet aggregation in whole blood
Atherosclerosis, 1985In vitro 'spontaneous' platelet aggregation has been studied in whole blood. The spectrum of activity of materials known to influence platelet aggregation in platelet-rich plasma proved different in whole blood. Thus dipyridamole and one of its analogues SH1242 had a striking effect in whole blood whilst aspirin, chlorpromazine and K3920 had little or ...
M J, Harrison +3 more
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Disposition of anagrelide, an inhibitor of platelet aggregation
Clinical Pharmacology and Therapeutics, 1981A single dose of 14C-anagrelide (6,7-dichloro-1,5-dihydroimidazo [2,1-b] quinazoline-2(3H)-one monohydrochloride) equivalent to 1 mg free base and containing 100 muCi radioactivity, was taken by five healthy, fasting men. Blood, plasma, urine, and feces were analyzed for total radioactivity. Plasma and urine concentrations of anagrelide were determined,
R C, Gaver +3 more
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20-Methylprostacyclin a powerful ‘unnatural’ platelet aggregation inhibitor
Prostaglandins, 1978Abstract 20-Methyl (ω-homo) prostacyclin was prepared. Its inhibiting property on ADP-induced aggregation of rat blood platelets was 2–3 times that of the natural prostacyclin.
D A, van Dorp +2 more
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Chapter 7. Platelet Aggregation Inhibitors
1971Publisher Summary This chapter presents an overview of the platelet aggregation inhibitors. The therapeutic approach to thromboembolic disease is based on the inhibition of platelet aggregation. The use of fibrinolytic agents for the dissolution of thrombi and the prophylactic use of anticoagulants for their prevention has been known for some time ...
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Cardamom extract as inhibitor of human platelet aggregation
Phytotherapy Research, 2005The inhibitory activity of cardamom extract was studied on human platelets. Platelet aggregation and lipid peroxidation were evaluated with platelet rich plasma (PRP) and platelet membranes, respectively, obtained from blood of healthy volunteers.
W Jessie, Suneetha, T P, Krishnakantha
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Ticlopidine: a new platelet aggregation inhibitor.
Clinical pharmacy, 1992The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage of ticlopidine are reviewed. Ticlopidine appears to inhibit platelet aggregation induced by adenosine diphosphate. Ticlopidine hydrochloride is rapidly absorbed after oral administration, and maximum antiplatelet effects occur one to three hours after the dose.
M K, Ito, A R, Smith, M L, Lee
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