Results 71 to 80 of about 74,252 (240)

A New Shear-Stress-Based Point-of-Care Technology for Evaluation of the Hemostatic Pattern in Whole Blood

open access: yesBiosensors
The currently available point-of-care hemostasis tests are burdened by criticisms concerning the use of different activators and inhibitors and the lack of dynamic flow.
Alessandro Foladore   +8 more
doaj   +1 more source

A physical description of the adhesion and aggregation of platelets [PDF]

open access: yesarXiv, 2015
The early stages of clot formation in blood vessels involve platelets adhesion-aggregation. Although these mechanisms have been extensively studied, gaps in their understanding still persist. We have performed detailed in-vitro experiments and developed a numerical model to better describe and understand this phenomenon.
arxiv  

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

open access: yesAdvanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu   +6 more
wiley   +1 more source

Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy

open access: yesAdvanced Functional Materials, EarlyView.
MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee   +6 more
wiley   +1 more source

Hierarchical self-assembly of anisotropic colloidal platelets [PDF]

open access: yesarXiv, 2020
Anisotropy at the level of the inter-particle interaction provides the particles with specific instructions for the self-assembly of target structures. The ability to synthesize non-spherical colloids, together with the possibility of controlling the particle bonding pattern via suitably placed interaction sites, is nowadays enlarging the playfield for
arxiv  

3D Nano‐architected Polymer Shell Enables Reconfigurable Stabilized Blue Phase Soft Crystals

open access: yesAdvanced Functional Materials, EarlyView.
Spherical polymer shells featuring nanostructure of blue phase (BP) disclinations form via in situ photo‐polymerization within BP liquid crystals, providing controlled anchoring for BP nucleation and growth at room temperature and beyond. This architected confinement enhances BP thermal stability over a broad temperature range while enabling dynamic ...
Sepideh Norouzi   +8 more
wiley   +1 more source

cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

open access: yesCell Communication and Signaling, 2019
Background The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation.
Stephanie Makhoul   +6 more
doaj   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

open access: yesAdvanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang   +9 more
wiley   +1 more source

Impact of acute exacerbations on platelet reactivity in chronic obstructive pulmonary disease patients

open access: yesInternational Journal of COPD, 2017
Mariana Muñoz-Esquerre,1 José Luis Ferreiro,2 Daniel Huertas,1,3 Ana Lucrecia Marcano,2 Marta López-Sánchez,1 Gerard Roura,2 Joan Antoni Gómez-Hospital,2 Jordi Dorca,1 Angel Cequier,2 Salud Santos1,3 1Department of ...
Muñoz-Esquerre M   +9 more
doaj  

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