Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects
Advanced Functional Materials, EarlyView.Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu +6 more
wiley +1 more source
Comparison of platelet antibody screen, crossmatching and HLA antibody testing in patients refractory to platelet transfusions. [PDF]
Transfus Apher Sci, 2023 Chapman JM, Wendt L, Knudson CM.
europepmc +1 more source
Electric Pulse Regulated MXene Based Nanozymes for Integrative Bioelectricity Immuno‐Cancer Therapy
Advanced Functional Materials, EarlyView.MXenzyme‐mediated bioelectricity cancer therapy (MXenzyme‐BECT) enhances cancer cell death through irreversible depolarization, ion channel disruption, ROS generation, and immunogenic cell death. Computational simulations reveal the electrical mechanisms by which MXenzyme acts on single cells and support to predict treatment parameters. Next‐generation
Sanghee Lee +6 more
wiley +1 more source
Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers. [PDF]
, 2019 BACKGROUND: Ticagrelor is an oral P2Y12 inhibitor that is used with aspirin to reduce the risk of ischemic events among patients with acute coronary syndromes or previous myocardial infarction.
Arnold, Susan E. +8 more
core +1 more source
Psoralen and ultraviolet A light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing [PDF]
, 2016 Psoralen and ultraviolet A light (PUNTA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft versus-host disease.
Compernolle, Veerle +7 more
core +2 more sources
Potential Neutralizing Antibodies Discovered for Novel Corona Virus Using Machine Learning [PDF]
arXiv, 2020 The fast and untraceable virus mutations take lives of thousands of people before the immune system can produce the inhibitory antibody. Recent outbreak of novel coronavirus infected and killed thousands of people in the world. Rapid methods in finding peptides or antibody sequences that can inhibit the viral epitopes of COVID-19 will save the life of ...
arxiv
Advanced Functional Materials, EarlyView.The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang +9 more
wiley +1 more source
Linchuang shenzangbing zazhi, 2018 Objective To explore the effects of anti-platelet membrane glycoprotein Ib alpha(GPIbα)antibody on the expression of peripheral GPIbα,alpha particle membrane glycoprotein(CD62 P)and lysosomal membrane protein(CD63)in maintenance hemodialysis(MHD)patients.
LUO Min-hong +7 more
doaj
Desialylation and Apoptosis in Immune Thrombocytopenia: Implications for Pathogenesis and Treatment
Current Issues in Molecular BiologyImmune thrombocytopenia (ITP) is an autoimmune disease in which platelet autoantibodies play a significant role in its pathogenesis. Regulatory T cell dysfunction and T cell-mediated cytotoxicity also contribute to thrombocytopenia. Current therapies are
Shiying Silvia Zheng, José Sail Perdomo
doaj +1 more source
Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration
Advanced Functional Materials, EarlyView.A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo +10 more
wiley +1 more source