Results 141 to 150 of about 175,124 (315)

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, EarlyView.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source

Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcγRIIA): a new option in HIT?

Blood Advances, 2019
: Activation of the platelet Fc-receptor CD32a (FcγRIIA) is an early and crucial step in the pathogenesis of heparin-induced thrombocytopenia type II (HIT) that has not been therapeutically targeted.
Luise Goldmann, Rundan Duan, Thorsten Kragh, Georg Wittmann, Christian Weber, Reinhard Lorenz, Philipp von Hundelshausen, Michael Spannagl, Wolfgang Siess   +8 more
doaj  

Rictor Ameliorates Acute Antibody‐Mediated Rejection Following Kidney Transplantation by Suppressing Macrophage M1 Polarization Through p65‐NLRP3 Axis

Advanced Science, EarlyView.
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni, Chengcheng Yang, Junqi Zhang, Zhou Hang, Ming Zheng, Dengyuan Feng, Qinghuan Shen, Jinxu Miao, Xulin Sun, Li Sun, Baixin Shen, Min Gu, Zijie Wang   +12 more
wiley   +1 more source

Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity

Advanced Science, EarlyView.
The co‐delivery of mRNAs encoding a CD47 inhibitor and a cytokine cocktail (interleukins 12, 15, and 21) via lipid nanoparticles enables effective localized immunotherapy. This strategy not only suppresses tumor progression but also enhances type 1 conventional dendritic cell (cDC1) differentiation and activates CD8+ T cells, thereby inducing robust ...
Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou   +14 more
wiley   +1 more source

Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex [PDF]

, 1983
Giovanni Di Minno, Perumal Thiagarajan, B Perussia, J Martinéz, Sandor S. Shapiro, Giorgio Trinchieri, S Murphy   +6 more
openalex   +1 more source

Red Blood Cell‐Induced Bacterial Margination Improves Microbial Hemoadsorption on Engineered Cell‐Depleted Thrombi, Restoring Severe Bacteremia in Rats

Advanced Science, EarlyView.
A highly efficient extracorporeal device for treating bacteremia is developed by integrating microfluidic bacterial margination and engineered cell‐depleted thrombi strategically constructed in the device. The rodent models, severely infected with antibiotic‐resistant bacteria, recover from bacteremia after two subsequent extracorporeal blood ...
Bong Hwan Jang, Su Hyun Jung, Seyong Kwon, Sung Jin Park, Joo H. Kang   +4 more
wiley   +1 more source

Transmembrane thiol isomerase TMX1 counterbalances the effect of ERp46 to inhibit platelet activation and integrin αIIbβ3 function

Research and Practice in Thrombosis and Haemostasis
Background: Previous studies have shown that thiol isomerases such as ERp46 positively regulate platelet function by reducing integrin αIIbβ3 disulfides, and the transmembrane thiol isomerase TMX1 negatively regulates integrin αIIbβ3 activation. However,
Zhenzhen Zhao, Yixin Cheng, Yaqiong Zhang, Meinan Peng, Yue Han, Depei Wu, Aizhen Yang, Yi Wu   +7 more
doaj  

Analyses of HLA antigens, especially HLA-A and -B interlocus antigen, on platelets with monoclonal antibodies and elisa assay.

, 1987
Yoshisuke Nose, Nobuo Araki, Hiroji Yamahira, Junya Shimizu, Kaoru Sato, Takako Nakatsuji, Kimiyoshi Tsuji, Kazuo Ōno   +7 more
openalex   +2 more sources

Platelet-mediated cytotoxicity. Role of antibody and C3, and localization of the cytotoxic system in membranes. [PDF]

, 1987
Sheri Slezak, David E. Symer, H. S. Shin
openalex   +1 more source

Comparative Analysis of Clinical Outcomes and Financial Aspects of Phototherapies and Immunotherapy for Cancer

Advanced Science, EarlyView.
This review compares clinical outcomes, translational progress, and global funding trends across cancer phototherapies—photodynamic, photothermal, and photoimmunotherapy—and conventional immunotherapy. It highlights differences in treatment efficacy, clinical trial status, financial investment, and regulatory challenges, providing a comprehensive ...
Deepak S. Chauhan, Kun Shao, Roopa Hebbandi Nanjundappa, Daniel‐Jiajun Yu, Marianne Stanford, Huile Gao, Channakeshava Sokke Umeshappa   +6 more
wiley   +1 more source