Results 271 to 280 of about 175,124 (315)

The detection of platelet antibodies by simultaneous analysis of specific platelet antibodies and the monoclonal antibody–specific immobilization of platelet antigens: an interlaboratory comparison

Transfusion, 2010
BACKGROUND: Glycoprotein (GP)‐specific platelet (PLT) antibodies can cause allo‐ or autoimmune thrombocytopenia. Their detection is of high diagnostic value. The simultaneous analysis of specific PLT antibodies (SASPA) assay is based on simultaneous detection of various PLT‐specific antibodies by flow cytometry and has entered routine use in our ...
Meike Goebel, Xuan Duc Nguyen, Harald Klüter, Michael Schober, Simon Panzer   +4 more
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Platelet Migration Inhibition Test for Platelet Antibodies

International Archives of Allergy and Immunology, 1977
A simplified methodology and parameters associated with the performance of a platelet migration inhibition test for the detection of antiplatelet-associated antibodies is described.
W. Chao, J.A. Maples, P. Inboriboon, M.M. Yokoyama, A. Inboriboon   +4 more
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Identification and Significance of Platelet Antibodies

New England Journal of Medicine, 1956
BLEEDING tendencies secondary to thrombopenia are of increasing frequency in medical, surgical and obstetric disorders. This has been attributed to diverse causes: chemotherapeutic agents1 , 2; insecticides3; increased incidence of leukemia4; radioisotopes; cytotoxic agents in industry5; complete blood replacement by transfusion during pulmonary or ...
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Cell Electrophoresis for the Detection of Platelet Antibodies

Vox Sanguinis, 1974
Abstract. Cell electrophoresis was studied as a method for the detection of antibodies against platelets. Use was made of a Zeiss cytopherometer. After replacement of the original copper‐copper sulfate electrodes by newly designed platinum electrodes, a good reproducibility of the method was obtained.Antiplatelet heteroantibodies and usually also ...
C. M. van der Weerdt, C.J. van Boxtel, C. P. Engelfriet   +2 more
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Platelet antibodies in immune thrombocytopenia

Blood Reviews, 1992
Several tests to detect antibodies to platelets in patients with immune thrombocytopenia have been developed over the 40 years since it was first noted that this disorder was mediated by antiplatelet factors. Early tests were crude and not reproducible. A major landmark was the quantitation of IgG immunoglobulin on platelet membrane and the observation
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Are Platelet-Antibody Tests Worthwhile?

New England Journal of Medicine, 1987
This issue of the Journal contains a report by Lehman et al. on a patient with autoimmune thrombocytopenia and lymphoreticular malignant disease, in whom state-of-the-art in vitro serologic methods...
openaire   +3 more sources

The Effect of HLA Antibodies on Platelet Aggregation

Scandinavian Journal of Immunology, 1977
Twelve different HLA antisera, detecting antigens of both A and B series and the superspecificities w4 and w6, were tested for platelet‐aggregating activity in 75 antiserum‐platelet combinations. The correlation between the HLA specificities of the antisera and the aggregating effect on platelets carrying the corresponding antigens was significant (P ...
G. Holmlund, K. Penttinen, A. Tiilikainen   +2 more
openaire   +3 more sources

Frozen Platelet Plates for Platelet Antibody Detection and Cross-Match

Vox Sanguinis, 1994
AbstractWe performed 2 studies aimed at developing a frozen platelet panel suitable for platelet cross‐matching. The stability of the most important platelet membrane glycoproteins and the reactivity of antigens of the human platelet antigen (HPA) and of the human leukocyte antigen (HLA) systems were evaluated with the platelet suspension ...
F. Marangoni, Laura Porretti, Paolo Rebulla, G. Sirchia   +3 more
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ES07.01 
Platelet antigens and antibody detection

Vox Sanguinis, 2004
Platelets are anucleate blood cells, which play an importantpart in haemostasis and maintenance of the integrity ofblood-vessel endothelium. Interaction of platelet glycopro-teins (GPs) with extracellular matrix proteins is critical tothis function.The original impetus for investigating the alloantigensfound on the GPs of the platelet membrane came ...
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Platelet antibodies in systemic lupus erythematosus

British Journal of Haematology, 1987
Summary. In systemic lupus erythematosus (SLE), the precise cause of the thrombocytopenia is unknown. Since platelet associated IgG is increased in many patients, it has been suggested that the destruction of platelets might be dependent on specific antibodies.In nine patients with SLE, platelet associated immunoglobulins were found together with free
Cécile Kaplan, J.Y. Muller, J.-P. Cartron, Dominique Blanchard, P. Champeix   +4 more
openaire   +3 more sources