Results 61 to 70 of about 939,403 (293)
Haematologica, 2019 Platelet destruction in immune thrombocytopenia is caused by autoreactive antibody and T-cell responses, most commonly directed against platelet glycoprotein IIb/IIIa.
Lindsay S. Hall +5 more
doaj +1 more source
Effect of heterologous antibody on human platelets [PDF]
Blood, 1976 Abstract The effect of heterologous anti-human platelet antibody on human platelet function was examined in the presence and absence of whole plasma as an in vitro model for antibody-induced immune damage to cells. Heterologous IgG anti-human platelet antibody mediated platelet aggregation and released serotonin from both platelets in ...
R W, Colman, A D, Schreiber
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
Kinetics of Free Platelet Decrease After ADP: Effect of Fibrinogen Binding Inhibitors
, 1995 Evaluation of platelet aggregation in vitro has generally been performed by the turbidometric method. This technique is largely insensitive to early events of aggregation which, are best evaluated by following the decrease in number of free-platelets ...
Rocca, Bianca
core +1 more source
Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns
Arthritis Care &Research, EarlyView.Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki +6 more
wiley +1 more source
Application and analysis of compatible platelets matching via antigen avoidance
Zhongguo shuxue zazhi[Objective] To investigate the application of antigen avoidance pattern for compatible platelets matching. [Methods] Samples from two patients with immune-mediated platelet transfusion refractoriness were screened for platelet antibodies using solid ...
WU Shaoyun +3 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2020 In a high‐risk patient with subacute heparin‐induced thrombocytopenia (HIT) type A (platelet count recovery following acute HIT but with persisting platelet‐activating antibodies), in whom urgent cardiac surgery was required, a key clinical question ...
Andreas Koster +5 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee +4 more
wiley +1 more source
Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]
, 2008 Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg +12 more
core +1 more source
Impact of HLA antigen and antibody expression on cross-matching and transfusion effect
Zhongguo shuxue zazhi[Objective] To study the relationship between the expression intensity of HLA-Ⅰ platelet antibodies in patients with platelet transfusion refractoriness (PTR) and platelet cross-matching, and to further evaluate other factors in order to provide relevant
HE Honghong +4 more
doaj +1 more source