Results 151 to 160 of about 182,278 (349)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Decreased mean platelet volume in panic disorder

Neuropsychiatric Disease and Treatment, 2014
Işil Göğçegöz Gül, Gül Eryilmaz, Eylem Özten, Gökben Hizli Sayar Neuropsychiatry Health, Practice, and Research Center, Uskudar University, Istanbul, Turkey Aim: The relationship between psychological stress ...
Göğçegöz Gül I, Eryılmaz G, Özten E, Hızlı Sayar G   +3 more
doaj  

Functional classification of RUNX1 variants in familial platelet disorder with associated myeloid malignancies. [PDF]

Leukemia, 2021
Decker M, Lammens T, Ferster A, Erlacher M, Yoshimi A, Niemeyer CM, Ernst MPT, Raaijmakers MHGP, Duployez N, Flaum A, Steinemann D, Schlegelberger B, Illig T, Ripperger T.   +13 more
europepmc   +1 more source

Single-platelet nanomechanics measured by high-throughput cytometry [PDF]

, 2016
Ahn, B., Baek, J., Bennett, C., Briones, M., Brown, A. C., Bunting, S., Chester, D., Ciciliano, J., Ciciliano, J., Cuadrado, J., Fay, M. E., Fernandez-Nieves, A., Lam, W. A., Mannino, R., Myers, D. R., Qiu, Y., Sakurai, Y., Smith, Michael L., Sulchek, T., Tennenbaum, M., Tran, R.   +20 more
core   +2 more sources

Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping

, 2017
Alexander Tischer, Venkata R. Machha, Juan Pablo Frontroth, Maria A. Brehm, Tobias Obser, Reinhard Schneppenheim, Leland Mayne, S. Walter Englander, Matthew Auton   +8 more
openalex   +2 more sources

Treatment of Tendon, Muscle and Ligament Injuries and Degenerative Joint Disorders with Homologous Platelet Rich Plasma Injection [PDF]

, 2018
Zeynep Altuntaş, Mahmut Altuntaş, Nedim Savacı   +2 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Germline copy number variants in RUNX1: An updated case report and a decade-old red herring

BJC Reports
Pathogenic/likely pathogenic (P/LP) germline variants in RUNX1 cause familial platelet disorder with associated myeloid malignancies (FPDMM), also known as RUNX1-Familial Platelet Disorder (RUNX1-FPD, or FPD), a condition characterized by qualitative and
Natalie T. Deuitch, Amra Kajdic, Erica Bresciani, Marshall S. Horwitz, Hamish S. Scott, Katie Craft, Shawn Chong, David J. Young, Lucy A. Godley, Paul P. Liu   +9 more
doaj   +1 more source

Restoring RUNX1 deficiency in RUNX1 familial platelet disorder by inhibiting its degradation. [PDF]

Blood Adv, 2021
Krutein MC, Hart MR, Anderson DJ, Jeffery J, Kotini AG, Dai J, Chien S, DelPriore M, Borst S, Maguire JA, French DL, Gadue P, Papapetrou EP, Keel SB, Becker PS, Horwitz MS.   +15 more
europepmc   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source