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A Novel Homozygous GFI1B Mutation in Siblings With Thrombocytopenia and Bleeding Tendency. [PDF]
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Pediatrics In Review, 2020
After vascular injury and exposure of subendothelial matrix proteins to the intravascular space, mediators of hemostasis are triggered and allow for clot formation and restoration of vascular integrity. Platelets are the mediators of primary hemostasis, creating a platelet plug and allowing for initial cessation of bleeding.
Katherine Regling, Meera Chitlur
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After vascular injury and exposure of subendothelial matrix proteins to the intravascular space, mediators of hemostasis are triggered and allow for clot formation and restoration of vascular integrity. Platelets are the mediators of primary hemostasis, creating a platelet plug and allowing for initial cessation of bleeding.
Katherine Regling, Meera Chitlur
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Hematology/Oncology Clinics of North America, 2021
Bleeding disorders due to platelet dysfunction are a common hematologic complication affecting patients, and typically present with mucocutaneous bleeding or hemorrhage. An inherited platelet disorder should be suspected in individuals with a suggestive family history and no identified secondary causes of bleeding.
Frederick D, Tsai +1 more
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Bleeding disorders due to platelet dysfunction are a common hematologic complication affecting patients, and typically present with mucocutaneous bleeding or hemorrhage. An inherited platelet disorder should be suspected in individuals with a suggestive family history and no identified secondary causes of bleeding.
Frederick D, Tsai +1 more
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The Indian Journal of Pediatrics, 2003
Platelet function disorders are a rare cause of bleeding in hematological practice. The inherited variety includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. The clinical presentation is usually mild with mainly mucocutaneous bleeds.
Gurjeewan, Garewal, J, Ahluwalia
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Platelet function disorders are a rare cause of bleeding in hematological practice. The inherited variety includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. The clinical presentation is usually mild with mainly mucocutaneous bleeds.
Gurjeewan, Garewal, J, Ahluwalia
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Quantitative Platelet Disorders
Veterinary Clinics of North America: Small Animal Practice, 1988Thrombocytopenia may be caused by abnormal platelet production, accelerated removal owing to immunologic or nonimmunologic reasons, or sequestration of platelets in the spleen. Bleeding associated with thrombocytopenia usually presents as petechial or ecchymotic hemorrhages or epistaxis.
B F, Feldman, K J, Thomason, N C, Jain
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Blood Coagulation & Fibrinolysis, 2015
Thrombocytes or platelets are anucleated cells derived from megakaryocytes by process of megakaryopoiesis, with maturation time of 4-5 days. They are small and discoid in shape with size ranging from 2 to 4 μm. The platelet concentration in blood varies between 150, 000 and 400, 000 cells/μl of blood.
Manasa, Krishnegowda +1 more
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Thrombocytes or platelets are anucleated cells derived from megakaryocytes by process of megakaryopoiesis, with maturation time of 4-5 days. They are small and discoid in shape with size ranging from 2 to 4 μm. The platelet concentration in blood varies between 150, 000 and 400, 000 cells/μl of blood.
Manasa, Krishnegowda +1 more
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Clinica Chimica Acta, 2008
Inherited platelet disorders are a rare, but probably underdiagnosed, cause of symptomatic bleeding. They are characterized by abnormalities of platelet number (inherited thrombocytopenias), function (inherited disorders of platelet function) or both.
M. Franchini +5 more
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Inherited platelet disorders are a rare, but probably underdiagnosed, cause of symptomatic bleeding. They are characterized by abnormalities of platelet number (inherited thrombocytopenias), function (inherited disorders of platelet function) or both.
M. Franchini +5 more
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Hematology/Oncology Clinics of North America, 2007
Congenital platelet disorders represent a rare group of diseases classified by either a qualitative or quantitative platelet defect. This article outlines the historical, clinical, laboratory, and genetic features of various inherited platelet disorders with attention given to updated information on disease classification, diagnosis, and genotypes.
Cindy E, Neunert, Janna M, Journeycake
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Congenital platelet disorders represent a rare group of diseases classified by either a qualitative or quantitative platelet defect. This article outlines the historical, clinical, laboratory, and genetic features of various inherited platelet disorders with attention given to updated information on disease classification, diagnosis, and genotypes.
Cindy E, Neunert, Janna M, Journeycake
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Blood Reviews, 1988
Congenital platelet disorders include thrombocytopathies and thrombocytopenias, which often occur in association. Thrombocytopathies constitute a model for exploring platelet physiology at the molecular level: adhesion, activation, release phenomena, aggregation.
S, Bellucci, J P, Caen
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Congenital platelet disorders include thrombocytopathies and thrombocytopenias, which often occur in association. Thrombocytopathies constitute a model for exploring platelet physiology at the molecular level: adhesion, activation, release phenomena, aggregation.
S, Bellucci, J P, Caen
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Thrombosis Research, 2016
In contrast to congenital platelet disorders, which are rare, acquired platelet dysfunctions are more common in clinical practice. Their main causes are medications and systemic/hematologic diseases. Typical clinical manifestations are mucosal bleeding, epistaxis, or superficial epidermal bleeding normally of modest entity. In most cases, the molecular
Caterina, Casari, Wolfgang, Bergmeier
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In contrast to congenital platelet disorders, which are rare, acquired platelet dysfunctions are more common in clinical practice. Their main causes are medications and systemic/hematologic diseases. Typical clinical manifestations are mucosal bleeding, epistaxis, or superficial epidermal bleeding normally of modest entity. In most cases, the molecular
Caterina, Casari, Wolfgang, Bergmeier
openaire +2 more sources