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Pediatrics In Review, 2020
After vascular injury and exposure of subendothelial matrix proteins to the intravascular space, mediators of hemostasis are triggered and allow for clot formation and restoration of vascular integrity. Platelets are the mediators of primary hemostasis, creating a platelet plug and allowing for initial cessation of bleeding.
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After vascular injury and exposure of subendothelial matrix proteins to the intravascular space, mediators of hemostasis are triggered and allow for clot formation and restoration of vascular integrity. Platelets are the mediators of primary hemostasis, creating a platelet plug and allowing for initial cessation of bleeding.
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Clinica Chimica Acta, 2008
Inherited platelet disorders are a rare, but probably underdiagnosed, cause of symptomatic bleeding. They are characterized by abnormalities of platelet number (inherited thrombocytopenias), function (inherited disorders of platelet function) or both.
M. Franchini +5 more
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Inherited platelet disorders are a rare, but probably underdiagnosed, cause of symptomatic bleeding. They are characterized by abnormalities of platelet number (inherited thrombocytopenias), function (inherited disorders of platelet function) or both.
M. Franchini +5 more
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Hematology/Oncology Clinics of North America, 2021
Bleeding disorders due to platelet dysfunction are a common hematologic complication affecting patients, and typically present with mucocutaneous bleeding or hemorrhage. An inherited platelet disorder should be suspected in individuals with a suggestive family history and no identified secondary causes of bleeding.
Elisabeth M. Battinelli +1 more
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Bleeding disorders due to platelet dysfunction are a common hematologic complication affecting patients, and typically present with mucocutaneous bleeding or hemorrhage. An inherited platelet disorder should be suspected in individuals with a suggestive family history and no identified secondary causes of bleeding.
Elisabeth M. Battinelli +1 more
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Disorders of platelet function
Disease-a-Month, 1992Platelets provide for primary hemostasis by forming a hemostatic plug at sites of vascular damage. They also provide a surface for the assembly of the coagulation protein complexes that generate thrombin, serve as a nidus for fibrin clots, and secrete factors involved in wound repair.
Michael A. Kolodziej, Joel S. Bennett
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The Indian Journal of Pediatrics, 2003
Platelet function disorders are a rare cause of bleeding in hematological practice. The inherited variety includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. The clinical presentation is usually mild with mainly mucocutaneous bleeds.
Gurjeewan Garewal, Jasmina Ahluwalia
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Platelet function disorders are a rare cause of bleeding in hematological practice. The inherited variety includes defects in platelet adhesion, aggregation, secretion and platelet procoagulant activities. The clinical presentation is usually mild with mainly mucocutaneous bleeds.
Gurjeewan Garewal, Jasmina Ahluwalia
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platelets and their disorders [PDF]
, 2015 Platelets play a key role in haemostasis, inflammation and cancer biology. They show specific structural elements, including invaginations of the plasma membrane, a network of residual smooth endoplasmic reticulum, a highly specialized cytoskeleton maintaining the discoid structure of platelets and several kinds of organelles.
CATANI, MARIA VALERIA +3 more
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Disorders of Platelets in Pregnancy
Obstetrical & Gynecological Survey, 1994No significant change in platelet number, function or life-span occurs during pregnancy. However, pregnancy may be complicated by various platelet abnormalities or platelets may be involved in pregnancy pathologies. Thrombocytopenia is the most common platelet disorder to affect pregnancy. It may occur in a number of clinical conditions and both immune
Arijit Biswas +2 more
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Quantitative Platelet Disorders
Veterinary Clinics of North America: Small Animal Practice, 1988Thrombocytopenia may be caused by abnormal platelet production, accelerated removal owing to immunologic or nonimmunologic reasons, or sequestration of platelets in the spleen. Bleeding associated with thrombocytopenia usually presents as petechial or ecchymotic hemorrhages or epistaxis.
Karen J. Thomason +2 more
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Hematology/Oncology Clinics of North America, 2007
Congenital platelet disorders represent a rare group of diseases classified by either a qualitative or quantitative platelet defect. This article outlines the historical, clinical, laboratory, and genetic features of various inherited platelet disorders with attention given to updated information on disease classification, diagnosis, and genotypes.
Janna M. Journeycake, Cindy E. Neunert
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Congenital platelet disorders represent a rare group of diseases classified by either a qualitative or quantitative platelet defect. This article outlines the historical, clinical, laboratory, and genetic features of various inherited platelet disorders with attention given to updated information on disease classification, diagnosis, and genotypes.
Janna M. Journeycake, Cindy E. Neunert
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Clinical Cytometry for Platelets and Platelet Disorders
Clinics in Laboratory Medicine, 2023Clinical flow cytometry tests for inherited and acquired platelet disorders are useful diagnostic tools but are not widely available. Flow cytometric methods are available to detect inherited glycoprotein deficiencies, granule release (secretion defects), drug-induced thrombocytopenias, presence of antiplatelet antibodies, and pharmacodynamic ...
Andrew L, Frelinger +1 more
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