Results 291 to 300 of about 629,196 (341)
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Circular dichroism of platelet factor 4
Archives of Biochemistry and Biophysics, 1988The circular dichroism of platelet factor 4 was investigated and it was found to contain 15% alpha-helix, 25% beta-structure, and the rest of the molecule in unordered conformation. In the presence of heparin, no change in the circular dichroism was observed, suggesting no significant changes in the secondary structure of platelet factor 4 when heparin
G B, Villanueva, N, Allen, D, Walz
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Platelet factor 4 release from the platelets stored in platelet concentrates
Transfusion, 1985Many consider that granular components of platelets should remain intact during storage of platelet concentrates (PCs) in order to participate in hemostasis when infused. The present investigations were done to determine factors affecting the release of an alpha‐granular component, platelet factor 4 (PF‐4), from platelets stored as PCs.
T, Shimizu +4 more
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Platelet Factor-4. Methods of Study
1972“Platelet Factor-4” (PF-4) indicates one or more factors exhibiting several biological functions (for review, see ref.3), the best known of which is the ability of neutralizing the anti- clotting activity of heparin; PF-4 is also able to neutralise the anticlotting activity of some fibrinogen degradation products and to induce non-enzymatic ...
M B, Donati +3 more
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Effect of Platelet-Activating Factor and Platelet Factor 4 on Eosinophil Adhesion
International Archives of Allergy and Immunology, 1994The effect of platelet-activating factor (PAF) and platelet factor 4 (PF4) on the adhesion of isolated human eosinophils or eosinophilic cell lines (EoL-1, EoL-3) was examined. Both PAF and PF4 augmented eosinophil adhesion to plates coated with AB plasma or recombinant soluble intercellular adhesion molecule-1 (r-sICAM-1).
N, Hayashi +6 more
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Platelet Factor 4: An Inhibitor of Collagenase
Science, 1978Human platelet factor 4 (PF4) is known to bind to heparin and inhibit its anticoagulant effect. This factor also inhibits the enzyme collagenase derived from cultured human skin and collagenase extracted from human granulocytes. The addition of heparin to the PF4-collagenase assay system has no effect on the observed inhibition of collagenase. Thus PF4
J, Hiti-Harper, H, Wohl, E, Harper
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Inactivation of Platelet Factor 4 in Plasma
Scandinavian Journal of Haematology, 1972Some factors, influencing the stability of platelet factor 4 (PF‐4) and of protamine in human plasma were investigated. PF‐4 and protamine were slowly inactivated in normal citrated plasma, but were stable when equivalent amounts of heparin were present. Plasmin enhanced the speed of inactivation.
C, Eika, H C, Godal
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Platelet factor 4: a chemokine enigma
The International Journal of Biochemistry & Cell Biology, 2005Platelet factor 4 (PF4) is a platelet alpha-granule protein sequenced over 25 years ago that is a founding member of the C-X-C chemokine family, yet its physiologic function has yet to be definitively established. Initial investigations focused on possible procoagulant roles for PF4 in platelet function and plasmatic coagulation.
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Platelet factor 4 enhances fibrin fiber polymerization
Thrombosis Research, 1987In order to further examine the role of platelet secretory products on fibrin assembly, we have examined the effects of purified platelet factor 4 (PF4) on fibrin formation in vitro. The kinetics of fibrin formation and the structural properties of the resulting fibrin gel are strongly affected by PF4. In the presence of 7.6 ng/mL PF4, the fibrin fiber
M E, Carr, G C, White, D A, Gabriel
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Platelet Factor 4 Activity and Thromboembolic Episodes
American Journal of Clinical Pathology, 1977Platelet factor 4 activity was evaluated in 323 patients who had various diseases. High incidences (30% or more) of elevated levels of platelet factor 4 were found in patients with recent myocardial infarctions, recent episodes of thromboembolism, hepatic diseases, and low platelet counts.
T, Okuno, D, Crockatt
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Recombinant Platelet Factor 4 for Heparin Neutralization
Seminars in Thrombosis and Hemostasis, 2004Protamine sulfate has been used for many years to reverse the effects of unfractionated heparin, but it can cause hemodynamic changes and other serious side effects. Platelet factor 4 (PF4) is a naturally occurring protein synthesized in megakaryocytes and eventually stored in the alpha granules of platelets for later release.
Timothy A, Mixon, Gregory J, Dehmer
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