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Platelet Factor 4 Binding Proteins
Thrombosis and Haemostasis, 1981Platelet factor 4 (PF-4) is a platelet alpha granule specific protein with a high affinity for heparin, and a progressively decreasing affinity for other glycosaminogly- cans. PF-4 is reportedly bound to a proteoglycan (PG) carrier within the platelet and can be dissociated by either high salts or by the presence of heparin. In an effort to isolate and
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Platelet Factor-4 Properties and Clinical Significance
1972In 1948, Conley and coworkers (2) observed that patients with thrombocytopenia had an increased sensitivity to heparin and suggested that platelets could counteract the anticoagulant effect of heparin. This observation was subsequently confirmed by other workers, who demonstrated that platelets contain a heparin-neutralizing substance (21, 42) referred
M B, Donati +3 more
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Blood, 2007
Lambert and colleagues use a cohort of genetically modified mice to demonstrate that platelet factor 4 (PF4) inhibits in vivo megakaryocytopoiesis, and thus propose a novel approach to counter chemotherapy-related thrombocytopenia.
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Lambert and colleagues use a cohort of genetically modified mice to demonstrate that platelet factor 4 (PF4) inhibits in vivo megakaryocytopoiesis, and thus propose a novel approach to counter chemotherapy-related thrombocytopenia.
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The prothrombotic potential of platelet factor 4
European Journal of Internal Medicine, 2010Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder initiated by heparin administration. It is caused by the formation of pathogenic antibodies to complexes of platelet factor-4 (PF4) and heparin on platelet surfaces that cause platelet activation, aggregation and thrombosis.
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BOVINE PLATELET ANTIHEPARIN PROTEIN: PLATELET FACTOR 4*
Annals of the New York Academy of Sciences, 1981R E, Ciaglowski, J W, Snow, D A, Walz
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Platelet Factor 4: An Inhibitor of Angiogenesis
Seminars in Thrombosis and Hemostasis, 2004Platelet factor 4 (PF4) is an antiangiogenic ELR-negative chemokine. PF4 inhibits endothelial cell proliferation and migration and angiogenesis in vitro and in vivo. Three different mechanisms have been proposed to explain PF4's antiangiogenic effects.
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5538949 modified platelet factor-4 and cleaved platelet factor 4
Transfusion Science, 1996openaire +2 more sources
PLATELET FACTOR 4 (PF 4) AND THE PLATELET MEMBRANE
Acta Medica Scandinavica, 1972openaire +2 more sources