Results 71 to 80 of about 2,127,148 (291)

Thrombotic thrombocytopenia associated with COVID-19 infection or vaccination: Possible paths to platelet factor 4 autoimmunity.

PLoS Medicine, 2021
Michel Goldman and Cédric Hermans discuss thrombotic mechanisms in COVID-19 and rare adverse reactions to SARS-CoV-2 vaccinations.
Michel Goldman, Cédric Hermans
doaj   +1 more source

A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1. [PDF]

Adv Sci (Weinh)
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Xie Q, Zhu Y, Jiang W, Xie H, Li Y, Hu M, Li K, Yu H, Pan Y, Jiang C, Song X, Fan D, Deng B.   +12 more
europepmc   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Distinct Specificity and Single-molecule Kinetics Characterize the Interaction of Pathogenic and Non-pathogenic Antibodies against Platelet Factor 4-Heparin Complexes with Platelet Factor 4*

Journal of Biological Chemistry, 2013
Background: Heparin-treated patients often develop antibodies, but only a subset cause heparin-induced thrombocytopenia. Results: In a single-molecule assay, a pathogenic monoclonal antibody bound more strongly to cross-linked platelet factor 4 than a ...
R. Litvinov, S. Yarovoi, L. Rauova, V. Barsegov, B. Sachais, A. Rux, Jillian L. Hinds, G. Arepally, D. Cines, J. Weisel   +9 more
semanticscholar   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

LOW INCIDENCE OF ANTI-PF4/HEPARIN ANTIBODIES IN PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA

Mediterranean Journal of Hematology and Infectious Diseases
Not available.
Håkon Reikvam, Ingvild Jenssen Lægreid, Ingvild Hausberg Sørvoll, Tom Sollid, Trude Victoria Mørtberg, Maria Therese Ahlén, Silje Johansen   +6 more
doaj   +1 more source

Platelet Factor 4 Activity against P. falciparum and Its Translation to Nonpeptidic Mimics as Antimalarials

Cell Host and Microbe, 2012
SUMMARY Plasmodium falciparum pathogenesis is affected by various cell types in the blood, including platelets, which can kill intraerythrocytic malaria parasites.
M. Love, Melanie G. Millholland, Satish Mishra, Swapnil J. Kulkarni, K. Freeman, Wen-Xi Pan, Robert W. Kavash, M. J. Costanzo, Hyunil Jo, T. Daly, Dewight R. Williams, M. Kowalska, L. W. Bergman, M. Poncz, W. DeGrado, Photini Sinnis, R. Scott, D. Greenbaum   +17 more
semanticscholar   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Great white sighting: a case of heparin-induced thrombosis with thrombocytosis

Research and Practice in Thrombosis and Haemostasis
Background: Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse response to heparin therapy, characterized by decreased platelet count and increased risk of thrombosis. HIT, without the tell-tale sign of thrombocytopenia, has rarely been
Julia Levy, Hong De Sa, Lindsey Loss, Mandy VanSandt, Rhusheet Patel, Merav Sendowski   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source