Results 1 to 10 of about 11,545 (115)

Platelet-Derived Microparticles Bearing PF4 and Anti-GAGS Immunoglobulins in Patients with Sepsis

Diagnostics, 2020
PF4 is a megakaryocyte-derived cationic chemokine that plays a part in innate immunity through its activity on the macrophages. In bacterial sepsis, PF4 binds to glycosaminoglycans (GAGs) on the surface of aerobic bacteria, giving rise to an antigenic ...
Elena Campello, Claudia Maria Radu, Paolo Simioni   +2 more
exaly   +3 more sources

Filamentous Pseudomonas Phage Pf4 in the Context of Therapy-Inducibility, Infectivity, Lysogenic Conversion, and Potential Application

Viruses, 2022
More than 20% of all Pseudomonas aeruginosa are infected with Pf4-related filamentous phage and although their role in virulence of P. aeruginosa strain PAO1 is well documented, its properties related to therapy are not elucidated in detail.
Petar Knezevic, Damir Gavric
exaly   +3 more sources

Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges [PDF]

Frontiers in Immunology
Platelet Factor 4 (PF4) is a CXC chemokine abundantly sequestered within platelet α-granules. Its modulatory roles in age-related dysfunction across cognitive, immune, and hematopoietic systems have garnered increasing research attention in recent years.
Yingying Guo, Zihua Liu, Weiwei Lu, Hao Zhuo, Zhicheng Wang, Xiaoning Wang   +5 more
doaj   +2 more sources

A cryptic symmetry switch allosterically controls how the PF4 self-protein turns into a pathogenic antigen [PDF]

Nature Communications
The asymmetry of dimers-of-dimers formed by Platelet Factor 4 (PF4) renders this endogenous protein immunogenic, triggering autoimmune responses such as heparin-induced thrombocytopenia (HIT).
Qiulin Ma, Jinfeng Huang, Ellen Mak, Karla Martinez Pomier, Pengxiao Zhou, Madoka Akimoto, Nikola Ivetic, Ishac Nazy, Giuseppe Melacini   +8 more
doaj   +2 more sources

Plasma PF4 is a reliable biomarker of platelet reactivity and predictive of bleeding risk in DAPT patients undergoing cardiac surgery [PDF]

Thrombosis Journal
Background Platelet activation is crucial for hemostasis and thrombosis, particularly in patients on antiplatelet therapy. Managing bleeding risk during cardiac surgery requires understanding platelet dynamics, especially when antiplatelet agents are ...
Joseph Roux de Bezieux, Julien Amour, Aurélien Philippe, Jeanne Rancic, Nicolas Gendron, Sébastien Bertil, Marc Garnier, Pascale Gaussem, David M. Smadja   +8 more
doaj   +2 more sources

Neutrophil extracellular traps and heparin-induced antibodies contribute to vascular access thrombosis in hemodialysis patients [PDF]

Kidney Research and Clinical Practice, 2021
Background Anti-heparin/platelet factor 4 (PF4) antibodies may trigger severe thrombotic complications in hemodialysis (HD) patients. Tetrameric PF4 has a high affinity for extracellular DNA, which is a key component of neutrophil extracellular traps ...
Hoi Woul Lee, Jung Nam An, Hyung Seok Lee, Young Rim Song, Hyung Jik Kim, Sung Gyun Kim, Jwa-Kyung Kim   +6 more
doaj   +1 more source

Platelets enhance CD4+ central memory T cell responses via platelet factor 4-dependent mitochondrial biogenesis and cell proliferation

Platelets, 2022
Platelets regulate multiple aspects of CD4+ T cell immunity, and may exert distinct regulations among different T cell subsets. Our aim was to investigate how platelets regulate CD4+ central memory T cell (Tcm) responses. αCD3/αCD28-stimulated human CD4+
Shuai Tan, Junhao Zhang, Yang Sun, Anton Gisterå, Zi Sheng, Rickard E. Malmström, Ming Hou, Jun Peng, Chunhong Ma, Wangjun Liao, Nailin Li   +10 more
doaj   +1 more source

Longitudinal Profiles of Anti-Platelet Factor 4 Antibodies in Thai People Who Received ChAdOx1 nCoV-19 Vaccination

Vaccines, 2023
Anti-platelet factor 4 (anti-PF4) antibodies were identified as pathogenic antibodies for vaccine-induced immune thrombocytopenia and thrombosis (VITT) in subjects receiving ChAdOx1 nCoV-19 vaccinations.
Nonthakorn Hantrakun, Peampost Sinsakolwat, Adisak Tantiworawit, Ekarat Rattarittamrong, Thanawat Rattanathammethee, Sasinee Hantrakool, Pokpong Piriyakhuntorn, Teerachat Punnachet, Piangrawee Niprapan, Ornkamon Wongtagan, Romanee Chaiwarith, Lalita Norasetthada, Chatree Chai-Adisaksopha   +12 more
doaj   +1 more source

Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts

Scientific Reports, 2022
Periodontitis is a chronic inflammatory disease characterized by the release of matrix metalloproteinases (MMPs) from resident connective tissue cells in tooth-supporting tissues (periodontium).
Hoa T. Le, Kalyan Golla, Ryan Karimi, Michael R. Hughes, Flavia Lakschevitz, Douglas B. Cines, M. Anna Kowalska, Mortimer Poncz, Kelly M. McNagny, Lari Häkkinen, Hugh Kim   +10 more
doaj   +1 more source

Vaccine induced thrombotic thrombocytopenia: development and reactivity of anti-platelet factor 4 antibodies and immune pathogenic mechanisms

Exploration of Immunology, 2022
In ultrarare cases, patients vaccinated with DNA adenovirus vector vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), develop a vaccine-induced immune thrombotic thrombocytopenia (VITT), with a high incidence of fatal cases ...
Jean Amiral, Elodie Legros, Marion Vivant, Delphine Rossi, Gwenaëlle Renaud   +4 more
doaj   +1 more source