Results 1 to 10 of about 2,127,148 (291)

The disparity of platelet factor 4 and platelets in individuals of different ages [PDF]

Heliyon
The aging process profoundly impacts the systemic milieu, with specific blood-borne factors playing critical roles in its regulation. Platelet Factor 4 (PF4), released by platelets, has emerged as a novel blood-borne factor that contributes to the ...
Ruopeng Weng, Jiaqing Liu, Qingtan Yu, Haitao Yuan, Yun Qiu, Huicong Liu, Lingna Wang, Zijie Mei, Fangfang Zhu   +8 more
doaj   +4 more sources

Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges [PDF]

Frontiers in Immunology
Platelet Factor 4 (PF4) is a CXC chemokine abundantly sequestered within platelet α-granules. Its modulatory roles in age-related dysfunction across cognitive, immune, and hematopoietic systems have garnered increasing research attention in recent years.
Yingying Guo, Zihua Liu, Weiwei Lu, Hao Zhuo, Zhicheng Wang, Xiaoning Wang   +5 more
doaj   +2 more sources

In platelet single donor apheresis, platelet factor 4 levels correlated with donor’s age and decreased during storage [PDF]

Scientific Reports
The human population is ageing worldwide. The World Health Organization estimated that the world’s population of people aged 60 years and older will increase to at least 30%, coinciding with a growing frequency of cognitive and cardiovascular disease ...
Anne Claire Duchez, Marco Heestermans, Charles-Antoine Arthaud, Marie-Ange Eyraud, Mailys Portier, Amélie Prier, Hind Hamzeh-Cognasse, Fabrice Cognasse   +7 more
doaj   +2 more sources

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders [PDF]

Advanced Science
Vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a new disorder that emerged in the wake of coronavirus disease 2019 (COVID‐19) vaccination.
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
doaj   +2 more sources

Anti‐platelet factor 4/heparin antibodies in patients with Hantaan virus infection [PDF]

Research and Practice in Thrombosis and Haemostasis, 2022
Background Hemorrhagic fever with renal syndrome (HFRS) induced by Hantaan virus infection and heparin‐induced thrombocytopenia (HIT) are associated with symptoms such as thrombocytopenia and thrombosis.
Meng Wang, Chun‐mei Zhang, Ying Ma, Kang Tang, Xi‐yue Zhang, Xiao‐zhou Jia, Hai‐feng Hu, Ran Zhuang, Bo‐quan Jin, Yu‐si Zhang, Yun Zhang   +10 more
doaj   +2 more sources

Platelet factor 4 and stromal cell-derived factor are novel prognostic biomarkers for cerebral vasospasm and mortality after subarachnoid hemorrhage [PDF]

Scientific Reports
Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition associated with high rates of morbidity and mortality, mainly due to post-hemorrhagic complications such as cerebral vasospasm (CVS) and delayed cerebral ischemia (DCI).
Dilaware Khan, Igor Fischer, Sihmehmet Sahan, Michael Hewera, Katharina Faust, Sajjad Muhammad   +5 more
doaj   +2 more sources

Molecular architecture and platelet-activating properties of small immune complexes assembled on heparin and platelet factor 4 [PDF]

Communications Biology
Heparin-induced thrombocytopenia (HIT) is an adverse reaction to heparin leading to a reduction in circulating platelets with an increased risk of thrombosis.
Yang Yang, Yi Du, Daniil Ivanov, Chendi Niu, Rumi Clare, James W. Smith, Ishac Nazy, Igor A. Kaltashov   +7 more
doaj   +2 more sources

Blood platelet factor 4: the elixir of brain rejuvenation [PDF]

Molecular Neurodegeneration
José M. Izquierdo
doaj   +2 more sources

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

New England Journal of Medicine, 2021
Background The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
M. Scully, Deepak Singh, R. Lown, A. Poles, Tom Solomon, M. Levi, D. Goldblatt, P. Kotoucek, W. Thomas, W. Lester   +9 more
semanticscholar   +1 more source

Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro.

PLoS ONE, 2021
Galectin-1 (gal-1) is a carbohydrate-binding lectin with important functions in angiogenesis, immune response, hemostasis and inflammation. Comparable functions are exerted by platelet factor 4 (CXCL4), a chemokine stored in the α-granules of platelets ...
Annemiek Dickhout, Bibian M E Tullemans, Johan W M Heemskerk, Victor L J L Thijssen, Marijke J E Kuijpers, Rory R Koenen   +5 more
doaj   +1 more source