Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice [PDF]
Nature Communications, 2023 The beneficial effects of physical activity on brain ageing are well recognised, with exerkines, factors that are secreted into the circulation in response to exercise, emerging as likely mediators of this response.
Odette Leiter +12 more
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Interactions of marine sulfated glycans with antithrombin and platelet factor 4 [PDF]
Frontiers in Molecular Biosciences, 2022 The molecular interactions of sulfated glycans, such as heparin, with antithrombin (AT) and platelet factor 4 (PF4) are essential for certain biological events such as anticoagulation and heparin induced thrombocytopenia (HIT).
Wenjing Zhang +6 more
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Novel adenovirus vaccine vectors lacking thrombosis-associated interactions with platelet factor 4 [PDF]
iScienceSummary: The adenoviral vector-based AstraZeneca and Janssen COVID-19 vaccines have been associated with rare cases of thrombosis, believed to be triggered, among other factors, by vector binding to the blood protein platelet factor 4 (PF4).
Erwan Sallard +31 more
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Monoclonal and oligoclonal anti-platelet factor 4 antibodies mediate VITT.
Blood, 2022 Kanack and colleagues analyze anti-platelet factor 4 antibodies from 5 patients with vaccine-induced thrombotic thrombocytopenia (VITT) secondary to COVID-19 adenoviral vaccination and antibodies from patients with spontaneous heparin-induced ...
Kanack AJ +15 more
europepmc +2 more sources
Platelet Factor 4: A Mysterious Chemokine in Inflammatory Regulation Diseases [PDF]
Journal of Inflammation ResearchYibing Ji,1,* Qian Zhang,2,* Hua Li,3,* Lixia Chen,3 Yuzhuo Wu,4 Sheng Lin1,2 1College of Pharmacy, Shandong Second Medical University, Weifang, Shandong, 261053, People’s Republic of China; 2Key Laboratory of Chinese Internal Medicine of ...
Ji Y, Zhang Q, Li H, Chen L, Wu Y, Lin S
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Blood Advances, 2016 : Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to
Douglas B. Cines +17 more
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Clinical Medical Reviews and ReportsPlatelet factor is a cytokine It is also known as chemokine ligand 4. It is released from alpha granules and promotes coagulation.
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Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts [PDF]
Scientific Reports, 2022 Periodontitis is a chronic inflammatory disease characterized by the release of matrix metalloproteinases (MMPs) from resident connective tissue cells in tooth-supporting tissues (periodontium).
Hoa T. Le +10 more
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Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity [PDF]
Nature Communications, 2017 Antibodies against the platelet factor 4 (PF4) support bacterial host defence but in some cases may lead to heparin-induced thrombocytopenia (HIT).
Thi-Huong Nguyen +3 more
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Platelet factor 4 induces bone loss by inhibiting the integrin α5‐FAK‐ERK pathway [PDF]
Animal Models and Experimental Medicine, 2023 Background The effect of platelet factor 4 (PF4) on bone marrow mesenchymal stem cells (BMMSCs) and osteoporosis is poorly understood. Therefore, this study aimed to evaluate the effects of PF4‐triggered bone destruction in mice and determine the ...
Wei Li +4 more
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