Results 31 to 40 of about 2,127,148 (291)

Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system

Cardiovascular Diabetology, 2022
Background Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence that there is a significant insoluble fibrin amyloid microclot load in the circulation
Arneaux Kruger, Mare Vlok, Simone Turner, Chantelle Venter, Gert Jacobus Laubscher, Douglas B. Kell, Etheresia Pretorius   +6 more
doaj   +1 more source

Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis

Frontiers in Veterinary Science, 2022
ObjectiveSeptic peritonitis is associated with significant morbidity and mortality. As a potential therapeutic agent in the treatment of sepsis, 2-O, 3-O desulfated heparin (ODSH) reduces histones and platelet factor 4 (PF4) in mouse sepsis models.
Katie D. Mauro, Michele P. Lambert, M. Anna Kowalska, Vincent J. Thawley, Mortimer Poncz, Cynthia M. Otto   +5 more
doaj   +1 more source

Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia

Thrombosis Journal, 2021
Background This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain coronavirus vaccines.
Payel Datta, Fuming Zhang, Jonathan S. Dordick, Robert J. Linhardt   +3 more
doaj   +1 more source

Prevalence of thrombocytopenia, anti–platelet factor 4 antibodies and D‐dimer elevation in Thai people After ChAdOx1 nCoV‐19 vaccination

Research and Practice in Thrombosis and Haemostasis, 2021
Background Vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a rare distinctive syndrome characterized by unusual site thrombosis accompanied by thrombocytopenia after ChAdOx1 nCoV‐19 vaccination.
Noppacharn Uaprasert, Phandee Watanaboonyongcharoen, Rattaporn Vichitratchaneekorn, Sasinipa Trithiphen, Benjaporn Akkawat, Autcharaporn Sukperm, Thanisa Tongbai, Watsamon Jantarabenjakul, Leilani Paitoonpong, Ponlapat Rojnuckarin   +9 more
doaj   +1 more source

Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice

Frontiers in Physiology, 2019
Platelet factor 4 (PF4) is a pleiotropic inflammatory chemokine, which has been implicated in various inflammatory disorders including liver fibrosis. However, its role in acute liver diseases has not yet been elucidated.
Hannah K. Drescher, Elisa F. Brandt, Petra Fischer, Stephan Dreschers, Reto A. Schwendener, M. Anna Kowalska, M. Anna Kowalska, Ali Canbay, Hermann E. Wasmuth, Ralf Weiskirchen, Christian Trautwein, Marie-Luise Berres, Daniela C. Kroy, Hacer Sahin   +13 more
doaj   +1 more source

Platelet factor 4 is a biomarker for lymphatic-promoted disorders.

JCI Insight, 2020
Genetic or acquired defects of the lymphatic vasculature often result in disfiguring, disabling and, occasionally, life-threatening clinical consequences.
Wanshu Ma, H. Gil, Noelia Escobedo, A. Benito-Martin, P. Ximénez-Embún, J. Muñoz, H. Peinado, S. Rockson, Guillermo Oliver   +8 more
semanticscholar   +1 more source

Reversal agents in anaesthesia and critical care

Indian Journal of Anaesthesia, 2015
Despite the advent of short and ultra-short acting drugs, an in-depth knowledge of the reversal agents used is a necessity for any anaesthesiologist.
Nibedita Pani, Pradeep A Dongare, Rajeeb Kumar Mishra   +2 more
doaj   +1 more source

Platelet factor 4 in platelet concentrates.

Journal of the Japan Society of Blood Transfusion, 1984
The release of platelet factor 4 (PF4) from platelets in platelet concentrates (PC) were investigated sequentially in the process of blood collection, and their storage at room temperature for up to 72h with agitation. No appreciable increase in PF4 release was seen immediately after blood collection.
Ishikawa, Yuko, Shimizu, Tetsuo, Hibi, Satomi, Tsurumi, Hiromi, Goto, Soji, Hasegawa, Iwazo, Fukuda, Tsuneo, Kato, Kanefusa   +7 more
openaire   +2 more sources

Classification of Platelet-Activating Anti-Platelet Factor 4 Disorders. [PDF]

Int J Lab Hematol
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent
Warkentin TE.
europepmc   +4 more sources

Vaccine-induced immune thrombotic thrombocytopaenia – overview

Studia Medyczne, 2022
In response to the ongoing COVID-19 pandemic, pharmaceutical companies have been able to rapidly develop and distribute effective vaccines. Despite some common, minor, local, and systemic adverse effects following vaccination, there is also, in rare ...
Jakub Sleziak, Antoni Gawor, Krzysztof Gomułka   +2 more
doaj   +1 more source