Results 41 to 50 of about 2,127,148 (291)

Platelet factor 4-containing immune complexes induce platelet activation followed by calpain-dependent platelet death

Cell Death Discovery, 2019
Heparin-induced thrombocytopenia (HIT) is a complication of heparin therapy sometimes associated with thrombosis. The hallmark of HIT is antibodies to the heparin/platelet factor 4 (PF4) complex that cause thrombocytopenia and thrombosis through platelet
T. A. Nevzorova, E. R. Mordakhanova, Amina G. Daminova, A. Ponomareva, I. Andrianova, G. Le Minh, L. Rauova, R. Litvinov, J. Weisel   +8 more
semanticscholar   +1 more source

Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin‐induced thrombocytopenia

Journal of Thrombosis and Haemostasis, 2019
Essentials Many patients produce antibodies but few lead to heparin‐induced thrombocytopenia (HIT). Pathogenic epitopes are difficult to identify as HIT antibodies are polyclonal and polyspecific.
A. Huynh, Donald M. Arnold, J. Kelton, J. Smith, P. Horsewood, R. Clare, A. Guarné, I. Nazy   +7 more
semanticscholar   +1 more source

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice

Nature Aging, 2023
Platelet factors regulate wound healing and can signal from the blood to the brain1,2. However, whether platelet factors modulate cognition, a highly valued and central manifestation of brain function, is unknown.
Cana Park, Oliver Hahn, Shweta Gupta, Arturo J. Moreno, Francesca Marino, Blen Kedir, Dan Wang, Saul A. Villeda, T. Wyss-Coray, D. Dubal   +9 more
semanticscholar   +1 more source

CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration

Scientific Reports, 2018
Activated platelets release micromolar concentrations of the chemokine CXCL4/Platelet Factor-4. Deposition of CXCL4 onto the vascular endothelium is involved in atherosclerosis, facilitating monocyte arrest and recruitment by an as yet, unidentified ...
J. M. Fox, Fahima Kausar, A. Day, M. Osborne, K. Hussain, A. Mueller, Jessica Lin, T. Tsuchiya, S. Kanegasaki, J. Pease   +9 more
semanticscholar   +1 more source

Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS

Journal of the Formosan Medical Association, 2019
Background/Purpose: Abnormal folliculogenesis is one of the cardinal presentations of polycystic ovarian syndrome (PCOS) and permeability of follicular wall has been proposed to be involved in the normal follicular growth.
Chu-Chun Huang, Chia-Hung Chou, Shee-Uan Chen, Hong-Nerng Ho, Yu-Shih Yang, Mei-Jou Chen   +5 more
doaj   +1 more source

Deterioration of vaccine‐induced immune thrombotic thrombocytopenia treated by heparin and platelet transfusion: Insight from functional cytometry and serotonin release assay

Research and Practice in Thrombosis and Haemostasis, 2021
We report a case of a 62‐year‐old man who developed cerebral venous sinus thrombosis with subarachnoid hemorrhage and concomitant thrombocytopenia, which occurred 13 days after ChAdOx1 nCov‐19 injection.
Alice Bérezné, David Bougon, Florence Blanc‐Jouvan, Nicolas Gendron, Cecile Janssen, Michel Muller, Sébastien Bertil, Florence Desvard, Isabelle Presot, Benjamin Terrier, Richard Chocron, Olivier Sanchez, Dominique Helley, David M. Smadja   +13 more
doaj   +1 more source

Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation*

Journal of Biological Chemistry, 2017
Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound healing. PF4 is stored in platelet α-granules bound to the glycosaminoglycan (GAG) chains of serglycin.
M. Lord, Bill Cheng, Brooke L. Farrugia, S. Mccarthy, J. Whitelock   +4 more
semanticscholar   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

PF4 (platelet factor 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Review on PF4, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
R. K. Van, P. Proost, Damme J Van, S. Struyf   +3 more
semanticscholar   +3 more sources

Development of a high-yield expression and purification system for platelet factor 4

Platelets, 2018
Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/
Angela Huynh, Donald M. Arnold, Jane C. Moore, James W. Smith, John G. Kelton, Ishac Nazy   +5 more
doaj   +1 more source