Results 21 to 30 of about 2,127,148 (291)

Anti-Platelet factor 4 immunothrombosis—not just heparin and vaccine triggers [PDF]

Research and Practice in Thrombosis and Haemostasis
Derailments at the tightly regulated interface of blood coagulation and innate inflammatory immune responses can lead to pathologic immunothrombosis. A special subset of immunothrombosis is caused by antibodies against platelet-factor 4 (PF4).
Luisa Müller, Jing Jing Wang, Venkata A.S. Dabbiru, Thomas Thiele, Linda Schönborn   +4 more
doaj   +2 more sources

Platelet Factor 4

Definitions, 2020

semanticscholar   +2 more sources

Platelet factor 4 triggers thrombo‐inflammation by bridging innate and adaptive immunity

International Journal of Laboratory Hematology, 2023
Platelet factor 4 (PF4, synonym: CXCL4) is an evolutionary old chemokine with proposed roles in hemostasis and antimicrobial defense. In addition, PF4 has attracted considerable attention as a crucial mediator of one of the most prothrombotic adverse ...
A. Greinacher, T. Warkentin
semanticscholar   +1 more source

Anti–platelet factor 4 antibodies causing VITT do not cross-react with SARS-CoV-2 spike protein

Blood, 2021
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and Janssen Ad26.COV2.S COVID-19 vaccine, and it is associated with unusual thrombosis.
A. Greinacher, K. Selleng, J. Mayerle, R. Palankar, J. Wesche, S. Reiche, A. Aebischer, T. Warkentin, M. Muenchhoff, J. Hellmuth, O. Keppler, Daniel Duerschmied, A. Lother, S. Rieg, M. Gawaz, K. Mueller, C. Scheer, M. Napp, K. Hahnenkamp, G. Lucchese, A. Vogelgesang, A. Flöel, P. Lovreglio, Angela Stufano, R. Marschalek, T. Thiele   +25 more
semanticscholar   +1 more source

Evaluation of laboratory assays for anti‐platelet factor 4 antibodies after ChAdOx1 nCOV‐19 vaccination

Journal of Thrombosis and Haemostasis, 2021
Vaccine‐induced immune thrombocytopenia and thrombosis (VITT) following ChAdOx1 nCOV‐19 vaccine has been described, associated with unusual site thrombosis, thrombocytopenia, raised D‐dimer, and high‐titer immunoglobulin‐G (IgG) class anti‐platelet ...
S. Platton, Andrew Bartlett, P. Maccallum, M. Makris, V. Mcdonald, Deepak Singh, M. Scully, S. Pavord   +7 more
semanticscholar   +1 more source

Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic.

Journal of the American Medical Association (JAMA), 2021
Importance Cases of cerebral venous sinus thrombosis in combination with thrombocytopenia have recently been reported within 4 to 28 days of vaccination with the ChAdOx1 nCov-19 (AstraZeneca/Oxford) and Ad.26.COV2.S (Janssen/Johnson & Johnson) COVID-19 ...
Mayte Sánchez van Kammen, M. Heldner, J. Brodard, A. Scutelnic, S. Silvis, V. Schroeder, J. Kremer Hovinga, S. Middeldorp, M. Levi, S. Hiltunen, E. Lindgren, M. Mansour, A. Arauz, M. Barboza, S. Zuurbier, Diana Aguiar de Sousa, J. Ferro, U. Fischer, Thalia Shoshana Field, K. Jood, T. Tatlisumak, J. Putaala, M. Arnold, J. Coutinho   +23 more
semanticscholar   +1 more source

The complicated relationships of heparin‐induced thrombocytopenia and platelet factor 4 antibodies with COVID‐19

International Journal of Laboratory Hematology, 2021
COVID‐19 (coronavirus disease 2019) represents a prothrombotic disorder, and there have been several reports of platelet factor 4/heparin antibodies being present in COVID‐19‐infected patients.
E. Favaloro, B. Henry, G. Lippi
semanticscholar   +1 more source

An affinity-based method for the purification of platelet factor 4 from outdated platelet concentrates [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  Platelet factor 4 (PF4) is considered as a chemokine mainly strode in the granules of platelets. Its important role in heparin-induced thrombocytopenia (HIT) was the basis of many investigations about this chemokine.
Alireza Goodarzi, Fatemeh Yari, Mahshid Mohammadipour   +2 more
doaj  

Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria. [PDF]

PLoS ONE, 2010
Cerebral malaria continues to be a difficult to treat complication of Plasmodium falciparum infection in children. We have shown that platelets can have major deleterious immune functions in experimental cerebral malaria (ECM).
Kalyan Srivastava, David J Field, Angela Aggrey, Munekazu Yamakuchi, Craig N Morrell   +4 more
doaj   +1 more source

Rapamycin as a potent and selective inhibitor of vascular endothelial growth factor receptor in breast carcinoma

International Journal of Immunopathology and Pharmacology, 2022
Angiogenesis is the process of new vascular formation, which is derived from various factors. For suppressing cancer cell growth, targeting angiogenesis is one of the therapeutic approaches.
Muhammad Shahidan Muhammad Sakri, Tengku Ahmad Damitri Al-Astani Tengku Din, Hasnan Jaafar, Vinod Gopalan, Wan Faiziah Wan Abdul Rahman   +4 more
doaj   +1 more source