Results 21 to 30 of about 11,617 (181)
Determinants of PF4/heparin immunogenicity
Blood, 2007 Heparin-induced thrombocytopenia (HIT) is an antibody-mediated disorder that occurs with variable frequency in patients exposed to heparin. HIT antibodies preferentially recognize large macromolecular complexes formed between PF4 and heparin over a narrow range of molar ratios, but the biophysical properties of complexes that initiate antibody ...
Shayela, Suvarna +7 more
openaire +3 more sources
Development of a high-yield expression and purification system for platelet factor 4
Platelets, 2018 Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/
Angela Huynh +5 more
doaj +1 more source
The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury. [PDF]
PLoS ONE, 2012 The robust inflammatory response that occurs during ischemia reperfusion (IR) injury recruits factors from both the innate and adaptive immune systems.
Peter H Lapchak +8 more
doaj +1 more source
Moving target PF4 directs HIT responses [PDF]
Blood, 2018 In this issue of Blood, Dai et al demonstrate a dynamic interchange of cell surface-bound platelet factor 4 (PF4) among hematopoietic and vascular cells that may limit the thrombocytopenia and promote prothrombotic processes in heparin-induced thrombocytopenia (HIT).
John W. Semple, Rick Kapur
openaire +2 more sources
BiomoleculesPathogenic platelet factor 4 (PF4) antibodies contributed to the abnormal coagulation profiles in COVID-19 and vaccinated patients. However, the mechanism of what triggers the body to produce these antibodies has not yet been clarified.
Thi-Huong Nguyen +6 more
doaj +1 more source
Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice
Frontiers in Physiology, 2019 Platelet factor 4 (PF4) is a pleiotropic inflammatory chemokine, which has been implicated in various inflammatory disorders including liver fibrosis. However, its role in acute liver diseases has not yet been elucidated.
Hannah K. Drescher +13 more
doaj +1 more source
An affinity-based method for the purification of platelet factor 4 from outdated platelet concentrates [PDF]
Journal of Research in Applied and Basic Medical Sciences, 2023 Background & Aims: Platelet factor 4 (PF4) is considered as a chemokine mainly strode in the granules of platelets. Its important role in heparin-induced thrombocytopenia (HIT) was the basis of many investigations about this chemokine.
Alireza Goodarzi +2 more
doaj
Platelet factor 4 induces bone loss by inhibiting the integrin α5‐FAK‐ERK pathway
Animal Models and Experimental Medicine, 2023 Background The effect of platelet factor 4 (PF4) on bone marrow mesenchymal stem cells (BMMSCs) and osteoporosis is poorly understood. Therefore, this study aimed to evaluate the effects of PF4‐triggered bone destruction in mice and determine the ...
Wei Li +4 more
doaj +1 more source
Recherche d’anticorps anti-PF4/héparine
Forum Médical Suisse ‒ Swiss Medical Forum, 2021 Cadre theorique et utilisation en clinique des anticorps anti-PF4/heparine dans le diagnostic d’une thrombopenie induite par l’heparine.
Nomie Parejas +2 more
openaire +1 more source
Research and Practice in Thrombosis and Haemostasis, 2022 Background Anti‐platelet factor 4 (PF4) antibodies that activate platelets via FcγRIIA drive the pathophysiology of vaccine‐induced immune thrombocytopenia and thrombosis (VITT). Evolution of these antibodies and their ability to activate platelets after
Samantha J. Montague +8 more
doaj +1 more source