Results 11 to 20 of about 11,617 (181)

Anti-PF4 antibodies and their relationship with COVID infection

Hematology, Transfusion and Cell Therapy
Detecting anti-PF4 antibodies remains the golden diagnostic method for heparin-induced thrombocytopenia (HIT) diagnosis with high sensitivity and specificity.
Chieh Yang, Irene Wang, Akshit Chitkara, Jibin Swankutty, Rushin Patel, Samir V Kubba   +5 more
doaj   +4 more sources

PF4 in rejuvenation therapy: neuroprotection and cognitive enhancement

Biomolecules & Biomedicine
Platelet factor 4 (PF4), a platelet-derived chemokine found in the blood, has been identified as a critical factor in modulating the rejuvenation of the aged brain.
Li Li, Chunming Xie
doaj   +4 more sources

KYNU in Gastric Cancer Cells Promotes Tumor Progression by Influencing Macrophage Polarization Via PF4. [PDF]

Cancer Sci
KYNU is upregulated in gastric cancer cells and activates the PI3K/Akt pathway, leading to PF4 secretion. PF4 drives nonclassical macrophage polarization with high expression of S100A8 and MMP7, which promotes tumor proliferation, migration, and invasion while suppressing phagocytosis, thereby accelerating gastric cancer progression.
Cui X, Li C, Liu Y, Liu C, Yang W.
europepmc   +2 more sources

Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases [PDF]

CNS Neurosci Ther
This review summarizes potential functions of platelet factor 4 (PF4) in neurodegenerative diseases (NDs) and discusses its promise as both a biomarker and a therapeutic target. Further elucidation of PF4 signaling pathways may provide new insights into disease mechanisms and uncover novel opportunities for targeted interventions in NDs.
Tian Q, Tong Y, Yu F, Hu X.
europepmc   +2 more sources

Thrombo-hemorrhagic liability in children with congenital heart diseases

Hematology/Oncology and Stem Cell Therapy, 2018
Background: The precise mechanisms of the increased incidence of hemostatic abnormalities in congenital heart disease (CHD) have not been determined. The aim of the study was to evaluate some indicators of activation of platelets and vascular endothelial
Shebl Said Shebl, Walid Ahmed Naguib El-shehaby, Yasmin Shebl Said, Amira Hamed Darwish, Nabeh Helal Elfadaly, Eman Amer   +5 more
doaj   +1 more source

Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma

Haematologica, 2013
Platelet factor 4 (PF4) is an angiostatic chemokine that suppresses tumor growth and metastasis. We previously revealed frequent transcriptional silencing of PF4 in multiple myeloma, but the functional roles of this chemokine are still unknown.
Pei Liang, Suk Hang Cheng, Chi Keung Cheng, Kin Mang Lau, Shek Ying Lin, Eudora Y.D. Chow, Natalie P.H. Chan, Rosalina K.L. Ip, Raymond S.M. Wong, Margaret H. L. Ng   +9 more
doaj   +1 more source

Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Blood Advances, 2016
: Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to
Douglas B. Cines, Serge V. Yarovoi, Sergei V. Zaitsev, Tatiana Lebedeva, Lubica Rauova, Mortimer Poncz, Gowthami M. Arepally, Sanjay Khandelwal, Victoria Stepanova, Ann H. Rux, Adam Cuker, Cecilia Guo, Linnette Mae Ocariza, Richard J. Travers, Stephanie A. Smith, Hugh Kim, James H. Morrissey, Edward M. Conway   +17 more
doaj   +1 more source

PF4 (platelet factor 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Review on PF4, with data on DNA/RNA, on the protein encoded and where the gene is implicated.
Van, Raemdonck K, Proost, P, Van, Damme J, Struyf, S   +3 more
openaire   +2 more sources

PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia

New England Journal of Medicine, 2021
Laboratory Method to Detect VITT The rare vaccine-induced immune thrombotic thrombocytopenia that may follow adenovirus-based Covid-19 vaccination resembles heparin-induced thrombocytopenia, but ra...
Vayne, Caroline, Rollin, Jérôme, Gruel, Yves, Pouplard, Claire, Galinat, Hubert, Huet, Olivier, Mémier, Vincent, Geeraerts, Thomas, Marlu, Raphael, Pernod, Gilles, Mourey, Guillaume, Fournel, Alexandra, Cordonnier, Charlotte, Susen, Sophie   +13 more
openaire   +4 more sources

Plasma and Urinary Platelet Factor 4 as Biomarkers for Cardiovascular Risk in Children with Chronic Kidney Disease

Biomedicines, 2023
Children suffering from chronic kidney disease (CKD) have a high risk of cardiovascular disease (CVD). The early detection and diagnosis of subclinical CVD in pediatric CKD can reduce mortality later in life. Plasma factor 4 (PF4) is a chemokine released
Chien-Ning Hsu, Wei-Ting Liao, Wei-Ling Chen, Guo-Ping Chang-Chien, Sufan Lin, You-Lin Tain   +5 more
doaj   +1 more source