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VITT Pathophysiology: An Update [PDF]

Vaccines
Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare thrombotic disorder first identified in 2021 as a catastrophic syndrome associated with anti-SARS-CoV-2 adenoviral vector (AdV)-vaccine administration.
Paolo Gresele, Eleonora Petito
exaly   +4 more sources

VITT with inactivated SARS-CoV-2 vaccine – index case

Human Vaccines and Immunotherapeutics, 2022
We report a case of vaccine-induced immune thrombotic thrombocytopenia (VITT) in a 73-year-old gentleman who presented with pulmonary embolism and thrombocytopenia, two weeks after receiving inactivated COVID-19 vaccine.
Syed Faisal Mahmood, Nosheen Nasir, Natasha Ali   +2 more
exaly   +2 more sources

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders [PDF]

Advanced Science
Vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a new disorder that emerged in the wake of coronavirus disease 2019 (COVID‐19) vaccination.
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
doaj   +2 more sources

COVID-19 Adenoviral Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT), COVID-19-Related Thrombosis, and the Thrombotic Thrombocytopenic Syndromes

Hematology Reports, 2022
Adenoviral-based vaccines such as ChadoX1 CoV-19 (AstraZeneca) and Ad26.COV2.S (J&J) were developed to prevent infection and reduce hospitalization or death in Coronavirus Disease 2019 (COVID-19) patients.
Rafael Vincent M Manalo, Joekeem D Arizala, Gewil Daniella Allas   +2 more
exaly   +3 more sources

Endothelial cell activation enhances thromboinflammation in vaccine-induced immune thrombotic thrombocytopenia [PDF]

Blood Advances
: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but serious complication of the ChAdOx1 nCOV-19 vaccine. In Australia, the diagnosis of VITT required the detection of antibodies against platelet factor 4 (PF4) in plasma using a PF4 ...
Alexander Dupuy, Xiaoming Liu, Yvonne Kong, Miao Qi, Jose Perdomo, Jemma Fenwick, Jessica Tieng, Bede Johnston, Qiyu Sara Shi, Mark Larance, Yingqi Zhang, Lining Arnold Ju, Paul Coleman, Jennifer Gamble, Elizabeth E. Gardiner, Mortimer Poncz, Huyen Tran, Vivien Chen, Freda H. Passam   +18 more
doaj   +2 more sources

Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT

Vaccines
Background/Objectives: Adenoviral vector-based vaccines against COVID-19 rarely cause vaccine-induced immune thrombocytopenia and thrombosis (VITT), a severe adverse reaction caused by IgG antibodies against platelet factor 4 (PF4).
Andreas Greinacher, Marta Broto, Linda Schönborn   +2 more
exaly   +3 more sources

Advances in our understanding of anti-PF4 related immunothrombosis [PDF]

Frontiers in Immunology
This article focuses on the central role of antibodies against platelet factor 4 (PF4) in mediating immunothrombosis, from classical heparin-induced thrombocytopenia (HIT) to vaccine-induced immune thrombocytopenia and thrombosis (VITT).
Luisa Müller, Patrycja Gebicka, Stefan Handtke, Linda Schönborn, Thomas Thiele   +4 more
doaj   +2 more sources

Diagnostic Reassessment of a Historical Case of Atypical Heparin-Induced Thrombocytopenia: Between Spontaneous Heparin-Induced Thrombocytopenia and a Vaccine-Induced Immune Thrombotic Thrombocytopenia-Like Syndrome [PDF]

Life
PF4-dependent disorders encompass a heterogeneous group of immune-mediated thrombotic syndromes, including heparin-induced thrombocytopenia (HIT), its autoimmune variants such as spontaneous HIT, and vaccine-induced immune thrombotic thrombocytopenia ...
Jordan Wimmer, Solène Kirscher, Manon Dolt, Agathe Herb, Léa Pierre, Lélia Grunebaum, Olivier Feugeas, Laurent Sattler, Dominique Desprez   +8 more
doaj   +2 more sources

Vaccine Induced Immune Thrombotic Thrombocytopenia After Sinopharm Vaccination: A Systematic Review of Case Reports [PDF]

Clinical Case Reports
Vaccine‐induced thrombotic thrombocytopenia (VITT) has been linked to vector‐based vaccines, but only four cases following whole‐virus vaccines (Sinopharm) have been reported, as far as we are aware.
Shafi Rehman, Mahnoor Sukaina, Hasibullah Aminpoor, Sissmol Davis, Amna Bint I Munir, Hasiba Karimi   +5 more
doaj   +2 more sources

Comparison of vaccine-induced immune thrombocytopenia and thrombosis cases following two adenovirus-vectored COVID-19 vaccines [PDF]

Communications Medicine
Background: Vaccine-induced immune thrombocytopenia and thrombosis (VITT) was first described after administration of adenovirus-vectored COVID-19 vaccines including Ad26.COV2.S and ChAdOx1 nCoV-19.
Rian Van Rampelbergh, Sue Pavord, Luis Anaya-Velarde, Vitalija van Paassen, Karin Hardt, Emiliano Tatar, Javier Ruiz-Guiñazú, Dawn Baumgardner, Valérie Oriol Mathieu, Nicolas Praet, Hendy Kristyanto, Jerald Sadoff, Macaya Douoguih, Yimei Xu, Frank Struyf   +14 more
doaj   +2 more sources