Results 31 to 40 of about 11,617 (181)

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies

Haematologica, 2022
In order to improve the safety of COVID-19 vaccines, there is an urgent need to unravel the pathogenesis of vaccineinduced immune thrombotic thrombocytopenia (VITT), a severe complication of recombinant adenoviral vector vaccines used to prevent COVID ...
Caroline Vayne, Raghavendra Palankar, Sandra Billy, Stefan Handtke, Thomas Thiele, Charlotte Cordonnier, Claire Pouplard, Andreas Greinacher, Yves Gruel, Jérôme Rollin   +9 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage

Folia Neuropathologica, 2023
Intracerebral haemorrhage (ICH) is a lethal cerebrovascular disorder with a high mortality and morbidity. Although it is a major public health problem, there is no effective treatment for ICH. After ICH, the primary and secondary mechanisms are mentioned
Na Hu, Ran An, Kun Yu, Yanzhong Chang, Weijuan Gao   +4 more
doaj   +1 more source

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source

Incidence of anti-platelet factor4/polyanionic antibodies, thrombocytopenia, and thrombosis after COVID-19 vaccination with ChAdOx1 nCoV-19 in Thais

Thrombosis Journal, 2023
Background The prevalence of anti-platelet factor 4 (PF4)/polyanionic antibodies occurring after vaccination with ChAdOx1 nCoV-19 is low. Most of these antibodies are not associated with vaccine-induced thrombotic thrombocytopenia.
Kochawan Boonyawat, Tichayapa Phojanasenee, Phichchapha Noikongdee, Pornnapa Police, Pichika Chantrathammachart, Pimjai Niparuck, Teeraya Puavilai, Angsana Phuphuakrat, Pantep Angchaisuksiri   +8 more
doaj   +1 more source

PF4 Promotes Platelet Production and Lung Cancer Growth [PDF]

Cell Reports, 2016
Co-option of host components by solid tumors facilitates cancer progression and can occur in both local tumor microenvironments and remote locations. At present, the signals involved in long-distance communication remain insufficiently understood. Here, we identify platelet factor 4 (PF4, CXCL4) as an endocrine factor whose overexpression in tumors ...
Pucci, Ferdinando, Rickelt, Steffen, Newton, Andita P, Garris, Christopher, Nunes, Ernesto, Evavold, Charles, Pfirschke, Christina, Engblom, Camilla, Mino-Kenudson, Mari, Hynes, Richard O, Weissleder, Ralph, Pittet, Mikaël   +11 more
openaire   +6 more sources

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Immune paradoxes of vaccine-induced thrombotic thrombocytopenia (VITТ), heparin-induced thrombocytopenia (HIT) and thrombosis: from general mechanisms to the unique VITТ and HIT course

Акушерство, гинекология и репродукция
Aim: to carry out a comparative analysis of the pathogenesis, clinical manifestations, diagnostic criteria as well as therapeutic strategies of vaccine-induced thrombotic thrombocytopenia (VITТ) and heparin-induced thrombocytopenia (HIT), two rare but ...
A. D. Makatsariya, S. V. Akinshina, A. V. Vorobev, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, N. A. Makatsariya, I. S. Kalashnikova, N. R. Gashimova, K. N. Grigoreva, I. A. Stepanov, I. M. Dikareva, A. Yu. Tatarintseva, A. V. Lazarchuk, A. R. Khisamieva, D. V. Blinov, P. Van Dreden, J.-Ch. Gris, I. Elalamy, G. Gerotziafas   +19 more
doaj   +1 more source

Bacterial outer membrane vesicles bound to bacteriophages modulate neutrophil responses to bacterial infection

Frontiers in Cellular and Infection Microbiology, 2023
Pseudomonas aeruginosa is a major human pathogen, particularly effective at colonizing the airways of patients with cystic fibrosis. Bacteriophages are highly abundant at infection sites, but their impact on mammalian immunity remains unclear.
Nina Pennetzdorfer, Medeea C. Popescu, Medeea C. Popescu, Naomi L. Haddock, Naomi L. Haddock, Fannie Dupuy, Fannie Dupuy, Gernot Kaber, Aviv Hargil, Patrik K. Johansson, Patrik K. Johansson, Annika Enejder, Annika Enejder, Paul L. Bollyky, Paul L. Bollyky   +14 more
doaj   +1 more source