Results 51 to 60 of about 11,617 (181)

Long-term persistence of high anti-PF4 antibodies titer in a challenging case of AZD1222 vaccine-induced thrombotic thrombocytopenia

Bleeding, Thrombosis and Vascular Biology, 2023
A syndrome occurring after adenoviral vector anti-SARS-CoV-2 vaccination, characterized by thrombocytopenia, venous thrombosis, and circulating anti-PF4 antibodies, known as vaccine-induced immune thrombotic thrombocytopenia (VITT), is well described ...
Luca Barcella, Chiara Ambaglio, Paolo Gritti, Francesca Schieppati, Varusca Brusegan, Eleonora Sanga, Marina Marchetti, Luca Lorini, Anna Falanga   +8 more
doaj   +1 more source

B cells, PF4/heparin complexes, and complement [PDF]

Blood, 2016
In this issue of Blood , [Khandelwal et al][1] show that B cells bind platelet factor 4 (PF4)/heparin complexes in a non–antigen-specific fashion, mediated by complement activation and resulting complex binding via B-cell complement receptors (CD21).[1][2] ![Figure][3] Activation ...
openaire   +2 more sources

Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide. [PDF]

Journal of Clinical Investigation, 1989
We report that highly purified human platelet factor 4 (PF4) inhibits human megakaryocytopoiesis in vitro. At greater than or equal to 25 micrograms/ml, PF4 inhibited megakaryocyte colony formation approximately 80% in unstimulated cultures, and approximately 58% in cultures containing recombinant human IL 3 and granulocyte-macrophage colony ...
Gewirtz AM, CALABRETTA, Bruno, Rucinski B, Niewiarowski S, Xu W.Y.   +4 more
openaire   +2 more sources

Bacteriophage P22 Virus‐Like Particles as Nanoscale Protein Scaffolds for Plant Synthetic Biology

Plant Biotechnology Journal, EarlyView.
ABSTRACT Advancing the utility of plant synthetic biology requires the continued development of protein engineering tools. Self‐assembling protein compartments, such as virus‐like particles (VLPs), provide versatile scaffolds for synthetic biology. However, few plant‐expressed VLPs have demonstrated broad amenability to protein engineering, restricting
Maxim D. Harding, Mark A. Jackson, Edward K. Gilding, David J. Craik, Frank Sainsbury, Nicole Lawrence   +5 more
wiley   +1 more source

Anti-Platelet factor 4 immunothrombosis—not just heparin and vaccine triggers

Research and Practice in Thrombosis and Haemostasis
Derailments at the tightly regulated interface of blood coagulation and innate inflammatory immune responses can lead to pathologic immunothrombosis. A special subset of immunothrombosis is caused by antibodies against platelet-factor 4 (PF4).
Luisa Müller, Jing Jing Wang, Venkata A.S. Dabbiru, Thomas Thiele, Linda Schönborn   +4 more
doaj   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

The clinical significance and risk factors of anti-platelet factor 4/heparin antibody on maintenance hemodialysis patients: a two-year prospective follow-up. [PDF]

PLoS ONE, 2013
BACKGROUND: Heparin-induced thrombocytopenia is an immune response mediated by anti-PF4/heparin antibody, which is clinically characterized by thrombocytopenia and thromboembolic events.
Delong Zhao, Xuefeng Sun, Li Yao, Hongli Lin, Jijun Li, Jiuyang Zhao, Zhimin Zhang, Lide Lun, Jianrong Zhang, Mingxu Li, Qi Huang, Yang Yang, Shimin Jiang, Yong Wang, Hanyu Zhu, Xiangmei Chen   +15 more
doaj   +1 more source

Biophysical tools to assess the interaction of PF4 with polyanions

Thrombosis and Haemostasis, 2016
SummaryThe antigen in heparin-induced thrombocytopenia (HIT) is expressed on platelet factor 4 (PF4) when PF4 complexes with polyanions. In recent years, biophysical tools (e. g. circular dichroism spectroscopy, atomic force microscopy, isothermal titration calorimetry, x-ray crystallography, electron microscopy) have gained an important role to ...
Delcea, Mihaela, Greinacher, Andreas
openaire   +2 more sources

Donor management implications for high‐sensitivity detection of low‐level malaria parasitemia in blood donor screening

Transfusion, EarlyView.
Abstract Introduction Transfusion‐transmitted malaria can occur when donors have unrecognized asymptomatic infection with submicroscopic parasitemia, highlighting the need to detect low‐level parasitemia in blood donor screening. However, these highly sensitive blood donor testing algorithms may refer donors to clinicians who use diagnostic algorithms ...
Carmen L. Charlton, Valerie Conrod, Dilini Kumaran, Craig Jenkins, Sandy Shokoples, LeeAnn Turnbull, Ruwandi Kariyawasam, Chantale Pambrun, Steven J. Drews   +8 more
wiley   +1 more source

PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3/PI3K/AKT/Nrf2 pathway

Biomolecules & Biomedicine
Inhibiting ferroptosis represents a promising strategy for managing neuronal injury caused by intracerebral hemorrhage (ICH). Platelet factor 4 (PF4), a chemokine with diverse biological functions, has an unclear role in ICH and its impact on neuronal ...
Na Hu, Yunfeng Li, Guohong Zhang, Wei Wang, Liping An, Ran An, Yu Liu   +6 more
doaj   +1 more source