Results 71 to 80 of about 11,617 (181)

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

The Proteome of Plasma Extracellular Vesicles in Latent and Active Tuberculosis Reveals Phase‐Specific Composition and Immunometabolic Insights

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
Plasma extracellular vesicles (EVs) from individuals with latent (LTB) or active tuberculosis (ATB) exhibit distinct proteomic compositions, reflecting the underlying immunometabolic states of each phase. In LTB, EVs are enriched in proteins associated with tissue remodeling and lipid metabolism, including TGFβ, APOA1, and APOE, which may participate ...
Eliud S.‐Peregrino, Jessica Castañeda‐Casimiro, Luis Vallejo‐Castillo, Mishelle Soria‐Fragoso, Gloria M. Ortega‐Díaz, Karen I. Mondragón‐Lara, Alfonso Méndez‐Tenorio, Rommel Chacón‐Salinas, Blanca E. García‐Pérez, Jeanet Serafín‐López, Carlos Wong‐Baeza, Víctor Hugo Rosales‐García, Alejandro Hernández‐Solis, Isabel Wong‐Baeza   +13 more
wiley   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, Volume 209, Issue 4, Page 1482-1485, October 2026.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Anti‐PF4 antibody inhibit proliferation of lung cancer cells without TP53 mutation by inducing apoptosis and cell cycle arrest

Clinical and Translational Discovery
Background Elevated platelet count is correlated with poor survival of lung cancer. Platelet factor 4 (PF4), a platelet‐specific protein, plays an important role in platelet function.
Mengjia Qian, Zhihui Min, Yanxia Zhan, Lili Ji, Bijun Zhu, Miaomiao Zhang, Qi Shen, Pengcheng Xu, Hao Chen, Yunfeng Cheng   +9 more
doaj   +1 more source

α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment

Blood Advances
: Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in thrombocytopoiesis and platelet function. Recently, α-actinin-1 mutations have been reported in patients with congenital macrothrombocytopenia.
Xiangjie Lin, Hanchen Gao, Min Xin, Jian Huang, Xia Li, Yutong Zhou, Keyu Lv, Xin Huang, Jinghan Wang, Yulan Zhou, Dawei Cui, Chao Fang, Lanlan Wu, Xiaofeng Shi, Zhixin Ma, Yu Qian, Hongyan Tong, Jing Dai, Jie Jin, Jiansong Huang   +19 more
doaj   +1 more source

Evaluation of Co‐Production in Adolescent Health Research: A Mixed Methods Study From Born in Bradford

Health Expectations, Volume 29, Issue 5, October 2026.
ABSTRACT Background Co‐production is often viewed as best practice for involving the public in research, while measures such as sharing power, reciprocity, and relationship‐building are seen as key guiding principles. However, implementing co‐production and its underlying principles remains challenging, with limited evaluative work examining how these ...
David Ryan, Adam Whitehead, Amelia Hudak, Edie Lee, Isobel Dowling, Jennie Ellul, Jennifer Ingram, Katy A. Shire, Shahid Islam, John Wright, Rosemary R. C. McEachan   +10 more
wiley   +1 more source

Anti-PF4 antibodies trigger a faster and stronger platelet procoagulant response than anti-heparin/PF4 antibodies

Blood Advances
: Vaccine-induced immune thrombocytopenia and thrombosis (VITT) and VITT-like syndromes are emerging causes of severe thrombocytopenia and thrombosis associated with immunoglobulin G (IgG) antibodies targeting platelet factor 4 (PF4). These syndromes are
Johanna Augros, Jérôme Rollin, Julie Benzakine, Estelle Archer, Sandra Billy, Annabelle Dupont, Mélanie Daniel, Yves Gruel, Claire Pouplard, Caroline Vayne   +9 more
doaj   +1 more source

PF4 inhibits ferroptosis-mediated intracerebral hemorrhage through modulating the CXCR3/AKT1/SLC7A11 signaling pathway

Biomolecules & Biomedicine
Ferroptosis plays a crucial role in the secondary pathophysiological damage to brain tissue surrounding hematomas after intracerebral hemorrhage (ICH). While platelet factor 4 (PF4) is known to promote regeneration following peripheral nerve injury, its
Na Hu, Guohong Zhang, Liping An, Wei Wang, Ran An, Yunfeng Li   +5 more
doaj   +1 more source

The disparity of platelet factor 4 and platelets in individuals of different ages

Heliyon
The aging process profoundly impacts the systemic milieu, with specific blood-borne factors playing critical roles in its regulation. Platelet Factor 4 (PF4), released by platelets, has emerged as a novel blood-borne factor that contributes to the ...
Ruopeng Weng, Jiaqing Liu, Qingtan Yu, Haitao Yuan, Yun Qiu, Huicong Liu, Lingna Wang, Zijie Mei, Fangfang Zhu   +8 more
doaj   +1 more source

TLR8 agonists remodel the tumor immune microenvironment through PF4-dependent T cell recruitment and ancillary mechanisms

Cancer Immunology, Immunotherapy
Pattern recognition receptors (PRRs) are crucial modulators of the tumor immune microenvironment (TIME); yet, their comparative efficacy remains poorly characterized.
Qikai Zhou, Zhixue Wang, Yixian Cao, Zhengheng Zheng, Wen Li, Zifeng Fu, Wenqin Luo, Wei-Qiang Gao, Bin Ma   +8 more
doaj   +1 more source