Results 211 to 220 of about 160,648 (299)

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi‐Omics Approach to Unravel the Mechanism

Advanced Science, EarlyView.
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang, Zhichao Li, Tianci Hu, Qinyao Li, Linwei Zhang, Xinyue Mei, Xiao Qi, Sheng Liu, Weijie Kong, Jiesi Luo, Anguo Wu, Feihong Huang, Sirui Li, Shuang Dai, Chunxiang Zhang, Rong Li, Jianming Wu   +16 more
wiley   +1 more source

Protocol for the CABG-PRIME Study (Coronary Artery Bypass Graft-Platelet Response and Improvement in Medicine Efficacy)-An Exploratory Study to Review the Role of Platelet Function Testing in Improving Patient Outcomes Post-CABG Surgery. [PDF]

J Cardiovasc Dev Dis
Comanici M, Das A, Camangon C, Kanchirassery K, Singh H, Lees NJ, Gorog D, Marczin N, Raja SG.   +8 more
europepmc   +1 more source

Evaluation of the platelet function of chronically uremic patients on regular dialysis treament by the platelet sensitivity test

, 1989
Yoshihiro Nakamura, Noriaki Matsui, Seinosuke Nakagawa   +2 more
openalex   +2 more sources

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Viscoelastic Hemostatic Assays in the Management of Trauma-Induced Coagulopathy: A Clinical Update. [PDF]

J Clin Med
Natalini D, Xhemalaj R, Carelli S.
europepmc   +1 more source

Different influences of hematocrit on the results of two Point-Of-Care platelet function tests, the VerifyNow assay and multiple electrode platelet aggregometry. [PDF]

PLoS One, 2014
Kim YG, Suh JW, Park JJ, Oh IY, Yoon CH, Cho YS, Youn TJ, Chae IH, Choi DJ.   +8 more
europepmc   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Platelet function abnormalities in acquired hemophilia A. [PDF]

Res Pract Thromb Haemost
Rossio R, Lecchi A, La Marca S, Padovan L, Gualtierotti R, Novembrino C, Suffritti C, Arcudi S, Ciavarella A, Boggio F, Siboni SM, Peyvandi F.   +11 more
europepmc   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

The Endothelial-Independent Effect of Desmopressin, In Vitro, on Platelet Function. [PDF]

Adv Hematol
Forner MV, Pretorius E, Venter C, Chetty S.   +3 more
europepmc   +1 more source