Results 181 to 190 of about 116,983 (327)

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, Volume 182, Issue 16, Page 3838-3851, August 2025.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel García, Alice Y. Pollitt   +8 more
wiley   +1 more source

Role of glycoproteins in hepatic lipid metabolism: emerging diagnostic markers and therapeutic targets. [PDF]

PeerJ
Lan B, Huang S, Luo J, Shi P, Qiang Z.
europepmc   +1 more source

Membrane type‐1 matrix metalloproteinase stimulates tumour cell‐induced platelet aggregation: role of receptor glycoproteins [PDF]

, 2004
David Alonso‐Escolano, Alex Y. Strongin, Ada W.Y. Chung, Elena I. Deryugina, Marek W. Radomski   +4 more
openalex   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Acute Life-Threatening Glycoprotein IIb/IIIa Inhibitor-Induced Thrombocytopenia Following Percutaneous Coronary Intervention (PCI): A Case Report and Review of the Literature. [PDF]

Cureus
Souman B, Wyant C, Parekh Z, Shokoohi C, Valina A.   +4 more
europepmc   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

The role of platelets in tumor immune evasion and metastasis: mechanisms and therapeutic implications. [PDF]

Cancer Cell Int
Gan J, Zhang X, Guo J.
europepmc   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, Volume 19, Issue 7, Page 1979-1997, July 2025.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Surface Engineering of Thrombus‐Targeting Nanocarriers for Cardiovascular Diseases: A Short Review

Advanced Materials Interfaces, Volume 12, Issue 13, July 14, 2025.
This paper systematically introduces surface modification strategies for thrombus‐targeting nanocarriers, highlights the clinical significance of nanocarrier‐based thrombolysis therapies, and prospects the synergy of combing thrombolysis and anti‐inflammatory therapies for enhanced therapeutic effect.
Xinyue Ge, Lei Ding, Wenjun Zhao, Bohan Cui, Xiang Guan, Mingfei Pan, Qingguo Li, Ning Gu   +7 more
wiley   +1 more source

Advances in Research on the Release of von Willebrand Factor from Endothelial Cells through the Membrane Attack Complex C5b-9 in Sepsis. [PDF]

J Inflamm Res
Liu Y, Zhao W, Huang Q, Wan L, Ren Z, Zhang B, Han C, Yang J, Zhang H, Zhang J.   +9 more
europepmc   +1 more source