Results 211 to 220 of about 116,983 (327)

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Cancer‐associated fibroblasts (CAFs) arise from normal fibroblasts in response to various tumor microenvironmental signals, including cytokines such as TGF‐β and IL‐6, paracrine factors like PDGFs, Notch signaling, extracellular vesicles, as well as aging, inflammation, hypoxia, oxidative stress, and increased extracellular matrix (ECM) stiffness. Upon
Yutao Li, Qingyun Liu, Xilin Jing, Yuqi Wang, Xiaohua Jia, Xing Yang, Kezhong Chen   +6 more
wiley   +1 more source

A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications. [PDF]

NPJ Genom Med
Shorbaji A, Pushparaj PN, Al-Ghafari AB, Mira LS, Basabrain MA, Naseer MI, Ahmed F, Abu-Elmagd M, Rasool M, Bakhashab S.   +9 more
europepmc   +1 more source

Antibody against platelet membrane glycoprotein VI in a patient with systemic lupus erythematosus

American journal of hematology/oncology, 2001
Hoyu Takahashi, M. Moroi
semanticscholar   +1 more source

The Biomaterial and Blood Clot Complex: A Crucial Early Environment for Osteo‐Coagulo‐Immunomodulation and the Advancement of Bone Biomaterials

Small Structures, Volume 6, Issue 7, July 2025.
Various properties of bone biomaterials can modulate components of the blood clot (including the fibrin network, red blood cells, platelets, and the complement system) in vivo implantation, leading to the formation of a biomaterial–blood clot complex (BBCC) significantly impacting subsequent osteoimmunomodulation.
Zongpu Han, Jieyun Xu, Xinyu Guo, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen, Yin Xiao, Zetao Chen   +11 more
wiley   +1 more source

Mechanism of antiphospholipid antibody-mediated thrombosis in antiphospholipid syndrome. [PDF]

Front Immunol
Yang L, Guo R, Liu H, Chen B, Li C, Liu R, Liao S, Xie Q, Yin G.   +8 more
europepmc   +1 more source

Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis

Brain Pathology, Volume 35, Issue 4, July 2025.
Graphical representation of the widespread white matter (blue color mask) and grey matter (cortical and deep grey matter; red color mask) demyelination in MS cases characterized by substantial inflammation of the CP (A). The presence of lesions was mainly associated with periventricular white matter and hippocampus areas (A).
R. Magliozzi, S. Hametner, M. Mastantuono, A. Mensi, M. Karimian, L. Griffiths, L. M. Watkins, A. Poli, G. M. Berti, E. Barusolo, B. Bellini, S. Rossi, D. Gveric, J. A. Stratton, K. Akassoglou, S. Magon, R. Nicholas, R. Reynolds, O. W. Howell, S. Monaco   +19 more
wiley   +1 more source

Alterations in the Processing of Platelet APP (Amyloid Beta Precursor Protein) in Alzheimer Disease: The Possible Nexus. [PDF]

Neuropsychopharmacol Rep
Al-Kuraishy HM, Sulaiman GM, Mohammed HA, Dawood RA, Albuhadily AK, Al-Gareeb AI, Abomughaid MM, Klionsky DJ.   +7 more
europepmc   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Rethinking FIB-4: The hidden zonal bias in alpha-1 antitrypsin deficiency. [PDF]

Hepatol Commun
Abdulrasak M.
europepmc   +1 more source

The Transmembrane Domains of β and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain

, 2015
Guofeng Xu, Dan Shang, Zuping Zhang, Tanner S. Shaw, Yali Ran, José A. López, Yuandong Peng   +6 more
openalex   +1 more source