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The Clinical Significance of Platelet Membrane Glycoproteins
Hematology/Oncology Clinics of North America, 1990To mediate their hemostatic functions, platelets must adhere to exposed vascular subendothelium and then aggregate. A variety of membrane glycoprotein receptors for adhesive ligands are present on platelets that promote adhesion and aggregation. Analysis of congenital disorders of platelet glycoproteins has been instrumental in clarifying our knowledge
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Further Characterization Of Platelet Membrane Glycoproteins
Thrombosis and Haemostasis, 1981The binding of 125I-labelled lectins to major and minor platelet glycoproteins (GP) and their subunits has been investigated. Human platelets were isolated, washed, solubilized in sodium dodecyl sulphate (SDS) under non-reducing conditions and separated on 5, 7.5 and 10 % non-reduced/reduced 2-D polyacrylamide gels.
E F Lüscher +9 more
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Thrombin interaction with platelet membrane glycoprotein Ibα [PDF]
Trends in Molecular Medicine, 2003 The interaction of thrombin with platelet glycoprotein Ibalpha (GPIb alpha) is required for optimal platelet activation. The crystal structures of platelet GPIb alpha bound to thrombin reported by Dumas et al. and Celikel et al. both reveal the simultaneous interaction of GPIb alpha with thrombin exosites I and II but differ markedly regarding how the ...
Marie-Christine Bouton +3 more
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Platelet Membrane Glycoproteins: Functions in Cellular Interactions
Annual Review of Cell Biology, 1990The understanding of the structure and function of platelet membrane glycoproteins has been facilitated by studies showing that they belong to larger gene families of cell surface receptors involved in cellular interactions. In some instances (e.g. GP IIb-IIIa and GP Ib-IX) the study of the platelet proteins has served as a prototype for relatively ...
N Kieffer, D R Phillips
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Studies on human and bovine platelet membrane glycoproteins
International Journal of Biochemistry, 1979Abstract 1. 1. We have re-evaluated the number of platelet membrane glycoproteins with use of sodium dodecyl sulfate—polyacrylamide gel electrophoresis and two highly sensitive detection techniques. 2. 2. The first involves incorporation of the fluorophore dansyi hydrazine into the carbohydrate moiety after post-electrophoresis periodate ...
Milton E. Noelken, John F. Mcmaster
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Platelet membrane glycoproteins and their function: An overview
Blut, 1989The membrane glycoproteins (GP) of human platelets act as receptors that mediate two important functions, adhesion to the subendothelial matrix and platelet-platelet cohesion, or aggregation. Many of these glycoprotein receptors exist as noncovalently linked heterodimers, including those that belong to the supergene family of adhesion receptors called ...
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Glycoproteins of the Platelet Plasma Membrane
1985The glycoproteins of the platelet plasma membrane, in common with those of the plasma membranes of other cells, have an important role in the interaction of platelets with their environment and in particular in the platelet’s function of hemostasis.
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On the role of the major platelet membrane glycoproteins in platelet adhesion to collagen
Thrombosis Research, 1981Abstract The effect of modification of intact rabbit platelets with chymotrypsin, trypsin or thrombin on platelet adhesion to collagen fibers was determined. Experiments were performed in vitro with washed platelets suspended in a medium containing EGTA to prevent platelet aggregation.
F. A. Meyer, J Lahav
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Structure and function of platelet membrane glycoproteins [PDF]
, 1993 Platelets are involved in a variety of cellular interactions that occur during the hemostatic and inflammatory responses to tissue injury. These include adhesion to extracellular matrix proteins (e.g. von Willebrand factor, collagen, fibronectin, vitronectin, laminin), homotypic interaction with each other to form a platelet plug, and heterotypic ...
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Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma
Leukemia Research, 2019Platelet activation and functional changes in some haematological malignancies have been investigated with little or no known documentation on Burkitt lymphoma (BL). Abnormalities of platelets contribute to either haemorrhage or thrombotic episodes which are life-threatening in patients with BL.
Renate Asare +10 more
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