Results 111 to 120 of about 96,906 (352)

Metabolism of ticagrelor in patients with acute coronary syndromes. [PDF]

, 2018
© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its ...
B Ibanez, C Varenhorst, D Alexopoulos, D Aradi, D Lindholm, D Zhou, EA Amsterdam, F Franchi, G Parodi, G Parodi, H Sillén, HS Smith, J Kubica, J Kubica, J Li, JH Cornel, JM Siller-Matula, K Butler, K Butler, K Thygesen, M Koziński, M Roffi, P Adamski, P Adamski, P Adamski, P Adamski, P Niezgoda, P Niezgoda, PG Steg, PG Steg, PT O’Gara, R Teng, R Teng, R Teng, R Teng, R Teng, R Teng, RA Lange, S Husted, S James, SE Husted, SS Brar   +41 more
core   +1 more source

Microplate Active Migration Emerging From Light‐Induced Phase Transitions in a Nematic Liquid Crystal

Advanced Functional Materials, EarlyView.
A quasi‐2D, light‐absorbing platelet embedded in a thermotropic nematic liquid crystal is activated with light irradiation. Depending on the light intensity, the platelet induces a localized nematic‐isotropic phase transition that triggers the motion. Using different confinements, the platelet can glide in a 2D regime or tilt and glide in a 3D regime ...
Antonio Tavera‐Vázquez, Danai Montalvan‐Sorrosa, Gustavo R. Perez‐Lemus, Otilio E. Rodriguez‐Lopez, Jose A. Martinez‐Gonzalez, Vinothan N. Manoharan, Juan J. de Pablo   +6 more
wiley   +1 more source

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]

, 2019
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar, Alvarez, Gabriella, Deschamps, Joshua, Holman, Theodore, Jacobson, Matthew P, Kalyanaraman, Chakrapani, Tena, Jennyfer, Tsai, Wan-Chen   +7 more
core   +2 more sources

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source

The multifaceted role of astrocytes in regulating myelination [PDF]

, 2016
Astrocytes are the major glial cell of the central nervous system (CNS), providing both metabolic and physical support to other neural cells. After injury, astrocytes become reactive and express a continuum of phenotypes which may be supportive or ...
Barnett, Susan C., Hosseinzadeh, Sara, Kiray, Hülya, Lindsay, Susan L.   +3 more
core   +2 more sources

Enhanced Sonodynamic Bacterial Elimination and Wound Healing Therapy Based on Lanthanide Ion Doped Bi2WO6 Nanosheets and Hydrogel Platform

Advanced Functional Materials, EarlyView.
Lanthanide ytterbium ions are introduced into Bi2WO6 nanosheets to boost ROS generation under US stimulation. These ytterbium‐doped Bi2WO6 nanosheets serve as efficient sonosensitizers, enabling broad‐spectrum bacterial eradication. To improve biocompatibility for in vivo sonodynamic therapy, the sonosensitizers are integrated into hydrogel matrix ...
Xinyue Lao, Qianqian Bai, Yifei Zhao, Xingyi Dai, Yuan Liu, Xiao Han, Jianhua Hao   +6 more
wiley   +1 more source

Sex differences in flow cytometry–based platelet reactivity in stable outpatients suspected of myocardial ischemia

Research and Practice in Thrombosis and Haemostasis, 2020
Background Antiplatelet therapy is the mainstay of secondary prevention of cardiovascular events. Studies suggest that women do not obtain equal therapeutic benefit from antiplatelet therapy compared with men. The link between sex differences in platelet
Farahnaz Waissi, Mirthe Dekker, Ingrid E.M. Bank, Suzanne J.A. Korporaal, Rolf T. Urbanus, Gert J. deBorst, Gerard Pasterkamp, Asbjorn M. Scholtens, Diederick E. Grobbee, Arend Mosterd, Dominique P.V. deKleijn, Leo Timmers   +11 more
doaj   +1 more source

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]

, 1992
Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Frank, R., Gausepohl, H., Klinz, F. J., Schultz, Günter, Schwaner, I., Seifert, Roland   +5 more
core   +1 more source

Platelet Reactivity and Pregnancy Loss

, 2011
Although many advances in reproductive medicine have been made during the past quarter century, miscarriage remains the most common complication of pregnancy. Recurrent Miscarriage (RM) is traditionally defined as three or more consecutive losses before 20 weeks post menstruation. A causal factor can be identified in less than half of affected couples,
openaire   +2 more sources

Platelet reactivity in patients with atrial fibrillation.

Journal of geriatric cardiology : JGC, 2016
We read the article entitled ‘Gender and tachycardia: independent modulation of platelet reactivity in patients with atrial fibrillation’ with great interest. In this article Procter, et al.[1] reported that gender and heart rate are independent determinants of platelet function in patients with acute atrial fibrillation (AF).
Fatih Özçelik, Namik Ozmen, Gokhan Degirmencioglu, Omer Yiginer   +3 more
openaire   +3 more sources