Results 51 to 60 of about 102,294 (349)

Suppression of platelet reactivity during dialysis by addition of a nitric oxide donor to the dialysis fluid

Renal Replacement Therapy, 2020
Background Dialysis membranes that release nitric oxide (NO) from their surface, mimicking one of the functions of endothelial cells, may suppress platelet reactivity during hemodialysis treatment.
Shunichiro Urabe, Kenichi Kokubo, Hiroshi Tsukao, Kozue Kobayashi, Minoru Hirose, Hirosuke Kobayashi   +5 more
doaj   +1 more source

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]

, 2019
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar, Alvarez, Gabriella, Deschamps, Joshua, Holman, Theodore, Jacobson, Matthew P, Kalyanaraman, Chakrapani, Tena, Jennyfer, Tsai, Wan-Chen   +7 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Increased platelet expression of FcGammaRIIa and its potential impact on platelet reactivity in patients with end stage renal disease

Thrombosis Journal, 2007
Background Increased platelet reactivity has been implicated in cardiovascular disease – the major cause of death in patients with end stage renal disease (ESRD).
Sobel Burton E, Solomon Richard J, El-Shahawy Mohamed, Serrano Feliciano A, Schneider David J   +4 more
doaj   +1 more source

Platelet microRNA-mRNA coexpression profiles correlate with platelet reactivity

Blood, 2011
Abstract MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects.
Srikanth, Nagalla, Chad, Shaw, Xianguo, Kong, Altaf A, Kondkar, Leonard C, Edelstein, Lin, Ma, Junmei, Chen, G Stanley, McKnight, José A, López, Linghai, Yang, Ying, Jin, Molly S, Bray, Suzanne M, Leal, Jing-Fei, Dong, Paul F, Bray   +14 more
openaire   +3 more sources

TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke [PDF]

, 2016
Clopidogrel is one of the most used antiplatelet drugs in patients with cardiovascular disease. However, 16% to 50% of patients have a high on-clopidogrel platelet reactivity and an increased risk of ischemic events. The pathogenesis of high on-treatment
Carrera, Caty, Cullell, Natalia, Fernandez-Cadenas, Israel, Fontana, Pierre, Gallego-Fabrega, Cristina, Krupinski, Jerzy, Martí-Fàbregas, Joan, Montaner, Joan, Muiño, Elena, Pera, Joanna, Pezzini, Alessandro, Reny, Jean-Luc, Segura, Tomás, Serrano-Heras, Gemma, Slowik, Agnieszka   +14 more
core   +2 more sources

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque [PDF]

, 2018
Experimental studies showed that gut-derived lipopolysaccharide (LPS) is pro-atherogenic, however, its relationship with human atherosclerosis is still to be defined.
Cammisotto, Vittoria, Carnevale, Roberto, Frati, Giacomo, Irace, Luigi, Martinelli, Ombretta, Nocella, Cristina, Pacini, Luca, Pastori, Daniele, Petrozza, Vincenzo, Sciarretta, Sebastiano, Sorrentino, Veronica, Violi, Francesco   +11 more
core   +2 more sources