Results 131 to 140 of about 206,755 (278)

Bortezomib‐based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single‐center retrospective study

Pediatric Investigation, EarlyView.
Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao, Jian Wang, Liping Que, Dunhua Zhou, Jianpei Fang, Luhong Xu   +5 more
wiley   +1 more source

Research progress on prevention strategies for immune platelet transfusion refractoriness

Platelet transfusion refractoriness (PTR) is a common issue among patients with hematological diseases and tumors. This article reviews the diagnostic criteria, influencing factors, and recent prevention and management strategies for immune PTR.
ZHAO Peizhe, LI Qing, LIANG Yajun, XU Xianguo, XU Yi, ZHOU Yuan   +5 more
core   +1 more source

Slot blotting and flow cytometry: two efficient assays for platelet antibody screening among patients with platelet refractoriness

, 2020
Background and Objectives: Frequent platelet transfusion may lead to the formation of alloantibodies and immune-mediated platelet destruction. Currently, identifying economic and effective screening methods is necessary for the management of platelet ...
Ameri, Z., Vahidi, R., Khaleghi, M., Farsinejad, A., Dehesh, T., Sheikhbardsiri, A.   +5 more
core  

Establishment of platelet donor registry improves the treatment of platelet transfusion refractoriness in Guangzhou region of China

, 2010
Platelet transfusion refractoriness (PTR) is the major complication of long-term platelet supportive care. To improve the effectiveness of platelet transfusion therapy in PTR patients, we aimed to establish a platelet donor registry in our region ...
Xu, Xiuzhang, Ye, Xin, Fu, Yongshui, Xia, Wenjie, Santoso, Sentot, Chen, Yangkai, Deng, Jing, Luo, Guangping, Tian, Linwei, Bei, C. H., W. J. Xia, S. Santoso, L. W. Tian, G. P. Luo, Y. K. Chen, Y.S. Fu, X. Z. Xu, J. Deng, C. H. Bei, X. Ye   +19 more
core   +1 more source

Preclinical Efficacy and Safety Evaluation of a Novel Controlled‐Expansion ePTFE‐Covered TIPS Stent in a Swine Model

Portal Hypertension &Cirrhosis, EarlyView.
This preclinical study evaluated a novel controlled‐expansion expanded polytetrafluoroethylene (ePTFE)‐covered transjugular intrahepatic portosystemic shunt (TIPS) stent in 11 swine, demonstrating 100% technical success, excellent deployability, and durable 6‐month angiographic patency without thrombosis, migration, fracture, or device‐related toxicity.
Yi Xiang, Qi Zhang, Chuan Liu, Jiawei Zhang, Qingqiao Zhang, Changsheng Shi, Chunze Zhou, Yudong Zhang, Hongliang He, Hao Xie, Hui Shi, Haijian Guo, Wenjing Liu, Muqing Lin, Huajie Yu, Xiaolong Qi   +15 more
wiley   +1 more source

Skeletal Muscle Mass Improvement and Survival After TIPS in Patients With Cirrhosis and Low Skeletal Muscle Index

Portal Hypertension &Cirrhosis, EarlyView.
Sarcopenia is common in patients with cirrhosis and contributes to poor prognosis. This study investigated whether transjugular intrahepatic portosystemic shunt (TIPS) is associated with improvement in skeletal muscle mass and whether such improvement translates into better transplant‐free survival in patients with cirrhosis and low skeletal muscle ...
Qinnian Li, Jiamin Xu, Chenrui Zhang, Rongfang Tu, Weimin Bao, Yingmei Tang   +5 more
wiley   +1 more source

Pretransplant platelet transfusion refractoriness is not associated with platelet nonengraftment in T-replete hematopoietic progenitor cell transplantation for hematologic malignancies

, 2015
BACKGROUNDCellular engraftment after allogeneic hematopoietic progenitor cell transplantation (HPCT) can be affected by pre-HPCT antibodies against donor human leukocyte antigen (HLA; donor-specific antibodies [DSAs]), which are commonly acquired by ...
Kennedy, Glen A., Thornton, Alycia, Baidya, Shoma, Butler, Jason, Scott, Ashleigh, Morris, Kirk   +5 more
core   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Platelet Alloantibody Specificities in Multiply Transfused Patients. [PDF]

, 2008
Transfusion plays an important role in the management of patients with hematological malignancies and disorders. Patients during the induction chemotherapy may need multiple transfusion of platelets and red cells and may develop refractoriness ...
Madhan Kumar, B K
core