Results 121 to 130 of about 91,077,287 (299)

Baseline laboratory characteristics of the study population according to neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).

, 2015
Data is presented as mean ± SD or number (percentage)NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, hs-CRP high sensitivity C-reactive protein, eGFR estimated glomerular filtration rate according to the Modification of Diet in ...
Ae-Young Her (775370), Soe Hee Ann (775368), Kyoung Im Cho (775367), Gillian Balbir Singh (775369), Eun-Seok Shin (775371)   +4 more
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Prognostic values of preoperative platelet-to-lymphocyte ratio, albumin and hemoglobin in patients with non-metastatic colon cancer

, 2019
Zhigui Li,1 Zhaofen Xu,2 Yuqian Huang,1 Rui Zhao,1 Yaping Cui,1 Yong Zhou,1 Xiaoting Wu11Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People’s Republic of China; 2Department of Pathology,
Li Z, Huang Y, Zhao R, Cui Y, Zhou Y, Xu Z, Wu X   +6 more
core  

Neutrophil-lymphocyte and Platelet-lymphocyte Ratios in Febrile Seizures

, 2022
Introduction:The neutrophil-lymphocyte ratio (NLR) and the platelet-lymphocyte ratio (PLR) are accepted as the indicators of systemic inflammatory response.
Sonay İncesoy Özdemir, Halise Akça, Ayşegül Neşe Çitak Kurt, Özdemir, Sonay İncesoy, AKÇA, HALİSE, ÇITAK KURT, AYŞEGÜL NEŞE   +5 more
core   +1 more source

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study developed ECOS‐Net, a transformer‐based multitask framework integrating CT‐derived habitat and 2.5D deep learning features to simultaneously predict early disease control and overall survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors.
Xiaona Fu, Yusheng Guo, Bingxin Gong, Jie Lou, Ning Wang, Xuejun Chen, Hongtao Hu, Rundong Wang, Xiaofang Guo, Shanmei Li, Yangyang Xie, Shichao Long, Mengsi Li, Shubo Pan, Wen Shen, Zhaogang Zhang, Zifang Song, Pengchen Liang, Xiaoyun Liang, Peng Sun, Guilin Zhang, Shanshan Jiang, Jinxiang Zhang, Lian Yang   +23 more
wiley   +1 more source

Importance of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic obstructive pulmonary disease exacerbations

, 2021
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are markers of inflammation. Many cells and mediators have been found to be involved in the progression of chronic obstructive pulmonary disease (COPD).
Emri, Salih, Keles, Emine, Deniz Koksal, Salih Emri, Emine Keles, BABAOĞLU, ELİF, ElifTugce Korkmaz, SARINÇ ULAŞLI, SEVİNÇ, Korkmaz, Elif Tugce, Elif Babaoglu, SevincSarinc Ulasli, KÖKSAL, DENİZ   +11 more
core   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume in Adults with Hypothyroidism

Archives of Basic and Clinical Research, 2019
Objective: The aim of the present study was to investigate neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) in adult patients with hypothyroidism. Materials and Methods: The records of 496 patients with hypothyroidism and 5677 euthyroid healthy individuals were compared from the laboratory ...
MERTOĞLU, CUMA, KANTARCI, ABDULMECİT
openaire   +3 more sources