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Alloimmunization and Refractoriness to Platelet Transfusions
Laboratory Medicine, 1992Refractoriness to platelet transfusions due to alloimmunization is one of the most serious complications that can occur for a chronically transfused platelet recipient. Although the diagnosis and management of this condition are difficult, the available therapeutic choices are increasing. The increasing use of family and human leukocyte antigen–matched
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Refractoriness to Platelet Transfusions in Children with Acute Leukemia
Journal of Pediatric Hematology/Oncology, 1995We evaluated the incidence of clinically significant refractoriness to platelet transfusions in children with acute leukemia.We reviewed the complete transfusion records up to July 1993 of all 213 patients diagnosed with acute leukemia at our institution over the 4-year period 1987 to 1990.
J, DeCoteau +3 more
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Alloimmunization and Platelet Transfusion Refractoriness
1993Since over 20 years platelet transfusions are established therapy allowing prolonged survival of patients with hematologic and hemato-oncologic diseases.
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Diagnosis and management of refractoriness to platelet transfusion
Blood Reviews, 2001Improvements in the availability and quality of platelet transfusions have markedly reduced the morbidity and mortality associated with intensive myelosuppressive therapy. Alloimmunization and refractoriness to platelet transfusion remains a significant clinical problem, although the incidence of alloimmunization may be declining due to more widespread
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Complement as an Immune Barrier in Platelet Transfusion Refractoriness
Transfusion Medicine Reviews, 2019Patients with hematological cancers often have low platelet counts because of progressing bone marrow failure or cytostatic therapy. A large fraction of those patients need platelet transfusions, which can be life-saving if bleedings occur and also allow diagnostic and therapeutic interventions. The outcomes of platelet transfusions are not always easy
Stephan, Meinke +2 more
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SummaryABO‐non‐identical (ABO‐ni) platelets may be another risk factor for immune platelet transfusion refractoriness (i‐PTR). We examined the effect of such platelets on i‐PTR and subsequent platelet support through retrospective analysis of 17 322 New Zealand patients receiving ≥1 platelets.
Min‐Hi Han, Krishna Govind Badami
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Strategies for managing refractoriness to platelet transfusions.
Current hematology reports, 2003The availability of platelet transfusions made possible intensive, myelosuppressive therapy. Chronic transfusion support is often complicated by refractoriness to platelet transfusions characterized by inadequate post-transfusion platelet count increments. Refractoriness is most commonly associated with a variety of clinical factors.
Maria E, Dan, Charles A, Schiffer
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Refractoriness to Platelet Transfusions
American Journal of Clinical Pathology, 1989openaire +2 more sources
Platelet Transfusion Refractoriness: Controversial Issues
Clinical Medicine Review, 2018Javier Marco, Pilar Solves
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