Results 251 to 260 of about 5,003 (295)
Some of the next articles are maybe not open access.
Refractoriness to platelet transfusion
Current Opinion in Hematology, 2002This review discusses the causes of refractoriness to platelet transfusions and presents three options for its management. Platelet refractoriness is a complication of platelet transfusion that affects variable proportions of patients, mostly depending on their diagnosis, previous immunologic stimuli, and type of blood products used for transfusion.
openaire +3 more sources
Platelet Transfusion Refractory Patients
2009Publisher Summary This chapter focuses on an inappropriately low platelet count defined as platelet refractory, which develops following repeated platelet transfusions. The cause for platelet refractoriness is mentioned to be both non-immune and immune and etiology is often multifactorial.
John D. Roback, Jeanne E. Hendrickson
openaire +3 more sources
Alloimmune refractoriness to platelet transfusions
Current Opinion in Hematology, 1997Patients who are transfused on multiple occasions with red cells or platelets may develop platelet-reactive alloantibodies and experience decreased clinical responsiveness to platelet transfusion. This situation, conventionally described as "refractoriness to platelet transfusions," is defined by an unsatisfactory low post-transfusion platelet count ...
openaire +3 more sources
Alloimmunization and Refractoriness to Platelet Transfusions
Laboratory Medicine, 1992Refractoriness to platelet transfusions due to alloimmunization is one of the most serious complications that can occur for a chronically transfused platelet recipient. Although the diagnosis and management of this condition are difficult, the available therapeutic choices are increasing. The increasing use of family and human leukocyte antigen–matched
openaire +2 more sources
Alloimmunization and Platelet Transfusion Refractoriness [PDF]
, 1993 Since over 20 years platelet transfusions are established therapy allowing prolonged survival of patients with hematologic and hemato-oncologic diseases.
openaire +1 more source
Refractoriness to Platelet Transfusions in Children with Acute Leukemia
Journal of Pediatric Hematology/Oncology, 1995We evaluated the incidence of clinically significant refractoriness to platelet transfusions in children with acute leukemia.We reviewed the complete transfusion records up to July 1993 of all 213 patients diagnosed with acute leukemia at our institution over the 4-year period 1987 to 1990.
Annette Poon +3 more
openaire +3 more sources
ABH antibodies causing platelet transfusion refractoriness
Transfusion, 1986Two alloimmunized patients with multispecific anti‐HLA and high‐titered ABH antibodies showed transfusion failures after ABH‐mismatched HLA‐identical platelet transfusions, whereas ABH‐matched HLA‐identical platelets showed sufficient increments. The anti‐A and ‐B could be demonstrated on platelets by immunofluorescence tests using FITC‐labeled goat ...
Anneke Brand +3 more
openaire +3 more sources
Diagnosis and management of refractoriness to platelet transfusion
Blood Reviews, 2001Improvements in the availability and quality of platelet transfusions have markedly reduced the morbidity and mortality associated with intensive myelosuppressive therapy. Alloimmunization and refractoriness to platelet transfusion remains a significant clinical problem, although the incidence of alloimmunization may be declining due to more widespread
openaire +3 more sources
Complement as an Immune Barrier in Platelet Transfusion Refractoriness
Transfusion Medicine Reviews, 2019Patients with hematological cancers often have low platelet counts because of progressing bone marrow failure or cytostatic therapy. A large fraction of those patients need platelet transfusions, which can be life-saving if bleedings occur and also allow diagnostic and therapeutic interventions. The outcomes of platelet transfusions are not always easy
Petter Höglund +3 more
openaire +3 more sources
Refractory Response to Platelet Transfusion Therapy
Journal of Infusion Nursing, 2010Platelet transfusions are commonly used for prophylaxis and treatment of bleeding. After a transfusion, an increment or "boost" is expected to occur. While a number of factors can contribute to a poor posttransfusion increment, refractoriness is typically defined as failure to achieve an appropriate increment after receiving 2 consecutive transfusions ...
openaire +3 more sources