Results 261 to 270 of about 5,003 (295)
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Transfusion of ABO‐mismatched platelets leads to early platelet refractoriness
British Journal of Haematology, 1990Summary. Forty‐three consecutive patients previously unexposed to platelets and undergoing treatment for acute leukaemia or autografting for relapsed Hodgkin's lymphoma were randomized to receive transfused platelets of either their own ABO group (OG) or of a major mismatched group (MMG).
Nigel W. Amphlett +4 more
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HLA-Universal Platelet Transfusions Prevent Platelet Refractoriness in a Mouse Model
Human Gene Therapy, 2013Refractoriness to platelet (PLT) transfusion caused by alloimmunization against HLA class I antigens constitutes a significant clinical problem. Thus, it would be desirable to have PLT units lacking HLA antigens on the cell surface. Previously, we showed that the generation of functional HLA class I-silenced (HLA-universal) PLTs from CD34(+) cells ...
Kai Schulze +5 more
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Extended platelet transfusion in bleeding patients with platelet transfusion refractoriness
Transfusion and Apheresis Science, 2023Tatiana, Fernández-Barge +6 more
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Treatment of refractoriness to platelet transfusion by protein A column therapy
Transfusion, 1993Ten thrombocytopenic patients (platelets < 10–24 × 10(9)/L) who were refractory to platelet transfusion were investigated for their responsiveness to staphylococcal protein A column therapy. Nine patients had previously been treated with steroids, intravenous immune globulin, and/or other forms of immunosuppressive therapy without improvement in ...
R B Howe +3 more
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Antibodies to plasma proteins: an association with platelet transfusion refractoriness
British Journal of Haematology, 1992Summary. We hypothesized that antibodies to HLA‐linked polymorphic plasma proteins could be involved in platelet refractoriness by an‘innocent bystander’or immune complex mechanism. Employing a kinetic enzyme‐linked immunosorbant assay (ELISA) technique the ability of IgG from the plasma of refractory patients to bind to albumin, fibrinogen ...
J. Cowles +4 more
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Transfusion and Apheresis Science, 2019
Platelet refractoriness, which leads to platelet transfusion failure resulting in significant morbidity and long hospital stay, is routinely not investigated.To determine the efficacy of cross-match compatible platelets in multi-transfused alloimmunized hemato-oncological patients refractory to platelet transfusion.149 ABO compatible single donor ...
Neelam Marwaha +6 more
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Platelet refractoriness, which leads to platelet transfusion failure resulting in significant morbidity and long hospital stay, is routinely not investigated.To determine the efficacy of cross-match compatible platelets in multi-transfused alloimmunized hemato-oncological patients refractory to platelet transfusion.149 ABO compatible single donor ...
Neelam Marwaha +6 more
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Clinical and laboratory factors underlying refractoriness to platelet transfusions
Journal of Clinical Apheresis, 1996Of the spectrum of clinical and laboratory factors responsible for refractoriness to platelet transfusions, some are amenable to intervention, some to circumvention, and others only to acceptance and support for complications. Identification of the likely reason for refractoriness in a given individual patient is critical to determine the optimum ...
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Challenge of Alloimmunization and Refractoriness to Platelet Transfusion
1997Alloimmunization and refractoriness to platelet transfusion remains the major problem following repeated platelet transfusions. Approaches to donor selection for alloimmunized recipients include a variety of strategies for HLA matching and platelet crossmatching of random donor units of platelet concentrates as a means of identifying new compatible ...
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New paradigms in the management of alloimmune refractoriness to platelet transfusions
Current Opinion in Hematology, 2007Following transfusion or pregnancy, a significant number of patients develop antibodies to class I human leukocyte antigen. Some will exhibit platelet transfusion refractoriness, defined as inappropriately low platelet count increments after two or more consecutive transfusions.
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Refractoriness to Platelet Transfusions
American Journal of Clinical Pathology, 1989openaire +3 more sources