Results 61 to 70 of about 3,449 (222)

Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija, Fiona Kerr, Hazel Gough, Johnathan Soggee, Laurence C. Cheung, Rishi S. Kotecha, Shanti Ramachandran   +6 more
wiley   +1 more source

Research progress on the pathogenesis, prevention and treatment of immune platelet transfusion refractoriness

Zhongguo shuxue zazhi
Platelet transfusion refractoriness (PTR) is one of the common problems in platelet transfusion, significantly impacting patient clinical outcomes and increasing the demand for allogeneic platelet transfusion.
LI Penghui, WU Chenggao, LE Aiping
doaj   +1 more source

Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients : a new classification from the European society for blood and marrow transplantation [PDF]

, 2017
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that ...
A Akil, A Balduzzi, A Helmy, A Iguchi, A Lankester, A Nagler, A Pagliuca, A S Schulz, A Yesilipek, AS Schulz, B Gibson, B Gruhn, B Horn, B Oshrine, B Rio, B Versluys, C Bredeson, C Cutler, C Peters, C Seifert, CC Barker, CK Li, CQ Fan, CR Uppugunduri, DK Cheuk, E Carreras, E Carreras, E Carreras, E Carreras, E Carreras, E Carreras, E Carreras, E Carreras, E Hod, E Trigoso, E Wallhult, F Dignan, F Dignan, F Locatelli, F Norol, FL Dignan, GB McDonald, GB McDonald, GJ Veal, H Boztug, HC Toh, HM Shulman, HM Shulman, I Yaniv, IH Bartelink, J Naples, J Stein, J Toporski, J Wachowiak, J-H Dalle, JA Coppell, JL Lee, JM McKoy, JS Kriegshauser, K Vetteranta, K Yakushijin, K-W Sykora, KC Myers, KJ Mortele, KJ Nazemi, L Zhang, LC Stork, M Ansari, M Elli, M Hashiguchi, M Mohty, M Mohty, M Mohty, M Ouachee-Chardin, M Palomo, M Qayed, M Wadleigh, MA Skeens, MB McCarville, MG Cefalo, MJ Sharafuddin, ML Sulis, MT Sartori, N Chao, N Lassau, N Yasui, P Bader, P Czauderna, P G Richardson, P Huezo-Diaz Curtis, P Kebriaei, P Richardson, P Sedlacek, PG Richardson, PG Richardson, PG Richardson, PG Richardson, R Malar, R Wynn, RA Nash, RJ Jones, RK Pai, S Cesaro, S Cesaro, S Cesaro, S Corbacioglu, S Corbacioglu, S Corbacioglu, S Corbacioglu, S Corbacioglu, S Grupp, S Tanikawa, SA Teefey, SC Hommeyer, SI Bearman, SI Bearman, SY Mahgerefteh, T Guengoer, T Schechter, V Mathews, WJ Hogan, Y Chalandon, Y Okamoto   +122 more
core   +3 more sources

A multicentre analysis of efficacy, safety and molecular response correlates of fostamatinib in warm autoimmune haemolytic anaemia and Evans syndrome

British Journal of Haematology, EarlyView.
Fostamatinib had 46% durable response, with 73% steroid reduction, in this multicentre retrospective study of refractory wAIHA/ES. Hypertension, gastrointestinal (GI) distress and neutropenia occurred in 23%. Only one patient required drug discontinuation and one patient dose reduction.
Jorge N. Ruiz Lopez, Lipei Shao, Debbie Jiang, Lawrence S. Bailey, Thejaswi Bikkani, Aaron Boothby, Donald C. Moore, Irina Murakhovskaya, Caroline I. Piatek, Mauricio Pineda‐Roman, Ping Jin, Jacqueline N. Poston, Moritz Stolla, David F. Stroncek, Krystalyn E. Hudson, James B. Bussel, Sandhya R. Panch   +16 more
wiley   +1 more source

A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation

Haematologica, 2018
HLA antibodies are associated with refractoriness to platelet transfusion, leading to rapid platelet clearance, sometimes coinciding with clinical side effects such as fever and chills.
Maaike Rijkers, Anno Saris, Sebastiaan Heidt, Arend Mulder, Leendert Porcelijn, Frans H.J. Claas, Ruben Bierings, Frank W.G. Leebeek, A.J. Gerard Jansen, Gestur Vidarsson, Jan Voorberg, Masja de Haas   +11 more
doaj   +1 more source

Simultaneous flow cytometric detection of antibodies against platelets, granulocytes and lymphocytes [PDF]

, 1991
We present a time-saving and objective flow cytometric immunofluorescence assay for the simultaneous detection of antibodies against platelets, granulocytes or lymphocytes using a reconstituted mixture of these cell populations.
Bolhuis, R.L.H. (Reinder), Gratama, J.W. (Jan-Willem), Linden, R. (Reinier) van der, Sintnicolaas, K. (Krijn), Vries, W. (Walter) de   +4 more
core   +1 more source

The international, prospective Glanzmann Thrombasthenia Registry: treatment and outcomes in surgical intervention

Haematologica, 2015
Standard treatment for Glanzmann thrombasthenia, a severe inherited bleeding disorder, is platelet transfusion. Recombinant factor VIIa is reported to be effective in Glanzmann thrombasthenia with platelet antibodies and/or refractoriness to platelet ...
Man-Chiu Poon, Roseline d’Oiron, Rainer B. Zotz, Niels Bindslev, Matteo Nicola Dario Di Minno, Giovanni Di Minno   +5 more
doaj   +1 more source

Immunological features of acquired pure red cell aplasia: Specific human leucocyte antigen alleles, signal transducer and activator of transcription 3 mutations and a unique T‐cell receptor beta motif

British Journal of Haematology, EarlyView.
Summary T‐cell abnormalities have been implicated in the pathogenesis of acquired pure red cell aplasia (PRCA), particularly in its major subtypes such as idiopathic PRCA, thymoma‐associated PRCA and large granular lymphocytic leukaemia (LGLL)–associated PRCA, and the precise details remain unclear.
Naruaki Yamashita, Toru Kawakami, Shuji Matsuzawa, Shotaro Miyairi, Masae Maruyama, Fumihiro Kawakami, Shunsuke Kojima, Ryu Yanagisawa, Yumiko Higuchi, Hideki Makishima, Hideyuki Nakazawa, Fumihiro Ishida   +11 more
wiley   +1 more source

Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111227/1/ccr3203 ...
Clark D. A., Ignace S., Leger RM, Sokol R. J.   +3 more
core   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source