Results 61 to 70 of about 48,011 (239)

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Biomarkers of Complement and Platelet Activation are not correlated with the One or Twenty-Four Hours Corrected Count Increments in Prophylactically Platelet Transfused Hematological Patients: a Prospective Cohort Study

Platelets, 2022
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson, Marcus Ljungkvist, Myriam Martin, Anna M. Blom, Jenny Klintman, Ulf Schött, Eva Zetterberg, Thomas Kander   +7 more
doaj   +1 more source

Tumor Infiltrating Lymphocyte Therapy Combined With PD‐1/LAG‐3 Inhibition in Patients With Recurrent Platinum‐Resistant Ovarian Cancer

International Journal of Cancer, EarlyView.
The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg, Cathrine L. Lorentzen, Marie C. W. Westergaard, Trine Z. Iversen, Troels H. Borch, Marco Donia, Sigrid M. Mannering, Stine E. W. Banke, Özcan Met, Inge Marie Svane   +9 more
wiley   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Management of Alloimmunized, Refractory Patients in Need of Platelet Transfusions [PDF]

Vox Sanguinis, 1997
immunization in patients whohave been previously immunized by pregnan-cy or transfusion is not prevented. Neither canimmunization against platelet-specific al-loantigens be prevented by removing leuco-cytes from platelet concentrates, but platelet-specific antibodies seem to occur mainly inpatients who develop HLA class I antibodies.Not all patients ...
Engelfriet, C. P., Reesink, H. W., Aster, R. H., Brand, A., Tomson, B., Claas, F. H., Contreras, M., Navarrete, C., Jørgensen, J., Murphy, M. F., Curtis, R., Waters, A. H., Panzer, S., Kurz, M., Höcker, P., Mayr, W. R., Schiffer, C. A.   +16 more
openaire   +4 more sources

Genetic Polymorphisms of HPA 1–6, 15 Systems in the Hangzhou Population and Their Role in the Management of Platelet Transfusion Refractoriness

, 2023
Background: The roles of human platelet antigens (HPAs) in the occurrence and management of platelet transfusion refractoriness (PTR) are still unclear.
Zhao, Yuhong, Cui, Dawei, Xie, Jue, Lv, Yan, Cao, Jianping   +4 more
core   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Chinese expert consensus on precision diagnosis, treatment, and multidisciplinary management of immune platelet transfusion refractoriness (2026 Edition)

Zhongguo shuxue zazhi
Patients with thrombocytopenia or platelet dysfunction often require platelet transfusions to improve their condition. However, some patients develop platelet transfusion refractoriness (PTR) after multiple transfusions, characterized by a lack of ...
Clinical Transfusion Medicine Professional Committee of the Chinese Society of Blood Transfusion
doaj   +1 more source

Platelet Transfusion Refractoriness in Single-Unit Cord Blood Transplantation for Adults: Risk Factors and Clinical Outcomes.

Biology of Blood and Marrow Transplantation, 2018
Platelet transfusion refractoriness (PTR) is frequently observed after allogeneic hematopoietic cell transplantation (HCT). However, the incidence of and risk factors for PTR, and impact of PTR on transplant outcomes after cord blood transplantation (CBT)
Susumu Tanoue, T. Konuma, S. Kato, M. Oiwa‐Monna, Masamichi Isobe, Koji Jimbo, Satoshi Takahashi, A. Tojo   +7 more
semanticscholar   +1 more source

Preclinical Efficacy and Safety Evaluation of a Novel Controlled‐Expansion ePTFE‐Covered TIPS Stent in a Swine Model

Portal Hypertension &Cirrhosis, EarlyView.
This preclinical study evaluated a novel controlled‐expansion expanded polytetrafluoroethylene (ePTFE)‐covered transjugular intrahepatic portosystemic shunt (TIPS) stent in 11 swine, demonstrating 100% technical success, excellent deployability, and durable 6‐month angiographic patency without thrombosis, migration, fracture, or device‐related toxicity.
Yi Xiang, Qi Zhang, Chuan Liu, Jiawei Zhang, Qingqiao Zhang, Changsheng Shi, Chunze Zhou, Yudong Zhang, Hongliang He, Hao Xie, Hui Shi, Haijian Guo, Wenjing Liu, Muqing Lin, Huajie Yu, Xiaolong Qi   +15 more
wiley   +1 more source