Results 51 to 60 of about 48,011 (239)

An Evaluation of Platelet Transfusion Response Using HLA Crossmatch-compatible Donors in Patients with Platelet Refractoriness [PDF]

, 2009
Background : Majority of immune-mediated platelet refractoriness is caused by HLA alloimmunization and can be effectively managed by HLA-matched platelet transfusions. However, HLA class I-typed large-sized donor registry has not been well established in
박경득, 현정원, 김양현, 박명희, 한규섭, 임영미, 한복연   +6 more
core   +1 more source

The association and functional relevance of genetic variation in low‐to‐medium‐affinity Fc‐gamma receptors with clinical platelet transfusion refractoriness

Journal of Thrombosis and Haemostasis, 2020
Inadequate responses to platelet transfusions (i.e., platelet transfusion refractoriness [PLT refractoriness]) are a serious problem. Multiple factors contribute to low yields upon platelet transfusion, among which are platelet‐reactive allo‐antibodies ...
S. Nagelkerke, L. Porcelijn, J. Geissler, M. Tanck, E. Huiskes, R. van Bruggen, T. K. van den Berg, M. de Haas, T. Kuijpers   +8 more
semanticscholar   +1 more source

Efficacy of apheresis platelet transfusion in 310 patients with haematological diseases

Zhongguo shuxue zazhi, 2023
Objective To observe the effect of platelet transfusion in inpatients with haematological diseases, analyze the possible causes of platelet transfusion refractoriness (PTR), in order to further improve the efficacy of platelet transfusion.
Shisong YOU, Liqi LU, Qun CAI, Xiaomei LI, Xiulan HUANG, Jingwei ZHANG   +5 more
doaj   +1 more source

Establishment of platelet donor registry improves the treatment of platelet transfusion refractoriness in Guangzhou region of China

, 2010
Platelet transfusion refractoriness (PTR) is the major complication of long-term platelet supportive care. To improve the effectiveness of platelet transfusion therapy in PTR patients, we aimed to establish a platelet donor registry in our region ...
Xu, Xiuzhang, Ye, Xin, Fu, Yongshui, Xia, Wenjie, Santoso, Sentot, Chen, Yangkai, Deng, Jing, Luo, Guangping, Tian, Linwei, Bei, C. H.   +9 more
core   +1 more source

Management of Patients Refractory to Platelet Transfusion

Archives of Pathology & Laboratory Medicine, 2003
Abstract Objective. —To present a current assessment and practical approach to the diagnosis and management of patients who are refractory to platelet transfusions. Design. —A task force was convened by the College of
Ronald A, Sacher, Thomas S, Kickler, Charles A, Schiffer, Laurence A, Sherman, Arthur W, Bracey, Ira A, Shulman   +5 more
openaire   +2 more sources

The Use Of A Potential Novel Tool In Virtual Crossmatching For Platelet Transfusion In Platelet Refractoriness

, 2016
Background and Objectives: Transfusion support for immune-mediated platelet refractoriness (PR) is clinically challenging, technically laborious and costly.
Sousa, L C D M, Castro, V, do Monte, S J H, Gonçalez, A C, Barjas-Castro, M L, Bub, C B   +5 more
core   +2 more sources

Analysis of HLA allele-specific antibodies and Eplets in patients with platelet transfusion refractoriness

, 2022
Objective To analyze the specificity and Eplets of HLA allele-specific antibody in patients with platelet transfusion refractoriness (PTR). Methods HLA-A and B genotypes were detected by PCR-SBT, and HLA-Ⅰ antibodies in patients′ serum were detected by ...
Xinyu HUANG, Ying LIU, Faming ZHU, Gang XU, Bing ZHANG, Xianguo XU, Shu CHEN   +6 more
core   +1 more source

Evaluation of PEscore performance in predicting platelet transfusion efficacy in hematological patients

Zhongguo shuxue zazhi
[Objective] To evaluate the performance of platelet efficacy score (PEscore) in predicting platelet transfusion efficacy in hematological patients. [Methods] A total of 485 patients with hematological diseases, including 298 males (62.09±15.45 years) and
LI Jun, WANG Lan, XIE Yihua, CHEN Ziqi, ZHAO Gang   +4 more
doaj   +1 more source

Platelet transfusion refractoriness in highly immunized beta thalassemia children undergoing stem cell transplantation

, 2010
Immune-mediated refractoriness to platelet transfusion is a major problem in patients undergoing HSCT. In a cohort of 50 pediatric patients affected by beta thalassemia coming from Middle East countries, we experienced a high incidence of refractoriness ...
Poli F, RONCAROLO , MARIA GRAZIA, Cappelli B, Marktel S, Fleischhauer K., Chiesa R, Rossini S, Zino E, Crocchiolo R, Ronchi P, Napolitano S, CICERI , FABIO   +11 more
core   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source