Results 51 to 60 of about 269,068 (254)

Platelet transfusion refractoriness in highly immunized beta thalassemia children undergoing stem cell transplantation

, 2010
Immune-mediated refractoriness to platelet transfusion is a major problem in patients undergoing HSCT. In a cohort of 50 pediatric patients affected by beta thalassemia coming from Middle East countries, we experienced a high incidence of refractoriness ...
Poli F, RONCAROLO , MARIA GRAZIA, Cappelli B, Marktel S, Fleischhauer K., Chiesa R, Rossini S, Zino E, Crocchiolo R, Ronchi P, Napolitano S, CICERI , FABIO   +11 more
core   +1 more source

Management of Alloimmunized, Refractory Patients in Need of Platelet Transfusions [PDF]

Vox Sanguinis, 1997
immunization in patients whohave been previously immunized by pregnan-cy or transfusion is not prevented. Neither canimmunization against platelet-specific al-loantigens be prevented by removing leuco-cytes from platelet concentrates, but platelet-specific antibodies seem to occur mainly inpatients who develop HLA class I antibodies.Not all patients ...
Engelfriet, C. P., Reesink, H. W., Aster, R. H., Brand, A., Tomson, B., Claas, F. H., Contreras, M., Navarrete, C., Jørgensen, J., Murphy, M. F., Curtis, R., Waters, A. H., Panzer, S., Kurz, M., Höcker, P., Mayr, W. R., Schiffer, C. A.   +16 more
openaire   +4 more sources

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Predictors of Corrected Count Increment after Pooled Platelet Concentrate Transfusion in Thrombocytopenic Patients: A Cohort Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Platelet transfusion is essential in managing thrombocytopenic patients to prevent or control bleeding. Corrected Count Increment (CCI) is a key measure of transfusion efficacy.
Sushree Sumedha Dash, Prajna Das, Biswajit Bhuyan   +2 more
doaj   +1 more source

Platelet Transfusion Refractoriness

, 2013
Platelet transfusion has been used for decades as a highly beneficial therapeutic measure to prevent or stop bleeding in patients with severe thrombocytopenia by increasing the circulatory platelet numbers.
Mortazavi, Reza; id_orcid
core   +1 more source

Biomarkers of Complement and Platelet Activation are not correlated with the One or Twenty-Four Hours Corrected Count Increments in Prophylactically Platelet Transfused Hematological Patients: a Prospective Cohort Study

Platelets, 2022
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of ...
Alexander Åkesson, Marcus Ljungkvist, Myriam Martin, Anna M. Blom, Jenny Klintman, Ulf Schött, Eva Zetterberg, Thomas Kander   +7 more
doaj   +1 more source

Laboratory analyses for evaluation of platelet disorders and platelet concentrates [PDF]

, 2006
High quality of platelet analytics requires specialized knowledge and skills. It was applied to analyze platelet activation and aggregation responses in a prospective controlled study of patients with Finnish type of amyloidosis.
Javela, Kaija
core  

Transfusion strategies for patients in pediatric intensive care units [PDF]

, 2007
Background: The optimal hemoglobin threshold for erythrocyte transfusions in critically ill children is unknown. We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe
Gauvin, France, Meert, Kathleen, Lacroix, J, Hume, HA, Lacroix, Jacques, Hutchinson, James S., Toledano, BJ, Peters, Mark J, Joffe, Ari, Collet, Jean-Paul, Gauvin, F, Ducruet, T, Hurne, Heather A., Robillard, P, Biarent, Dominique, Peters, MJ, Hutchison, JS, Toledano, Baruch J., Hebert, PC, Joffe, A, Biarent, D, Ducruet, Thierry, Collet, J-P, Meert, K, Tucci, Marisa, Robillard, Pierre, Hebert, Paul C., Tucci, M   +27 more
core   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

A mini-review on platelet refractoriness

Haematologica, 2005
BACKGROUND: Lack of adequate post-transfusion platelet count increments - platelet refractoriness - is a complication of chronic platelet support shown by 5-15% of chronic platelet recipients. INFORMATION SOURCES.
P Rebulla
doaj