Results 31 to 40 of about 48,011 (239)

Platelet transfusion refractoriness: how do I diagnose and manage? [PDF]

Hematology Am Soc Hematol Educ Program, 2020
Platelet refractoriness continues to be a problem for thrombocytopenic patients because the risk of a major spontaneous or life-threatening bleed significantly increases when platelet counts drop below 10 × 109/L.
Cohn CS.
europepmc   +2 more sources

Pretransplant platelet transfusion refractoriness is not associated with platelet nonengraftment in T-replete hematopoietic progenitor cell transplantation for hematologic malignancies

Transfusion, 2015
BACKGROUNDCellular engraftment after allogeneic hematopoietic progenitor cell transplantation (HPCT) can be affected by pre-HPCT antibodies against donor human leukocyte antigen (HLA; donor-specific antibodies [DSAs]), which are commonly acquired by ...
Kennedy, Glen A., Thornton, Alycia, Baidya, Shoma, Butler, Jason, Scott, Ashleigh, Morris, Kirk   +5 more
core   +2 more sources

A pilot trial of complement inhibition using eculizumab to overcome platelet transfusion refractoriness in human leukocyte antigen allo-immunized patients. [PDF]

Br J Haematol, 2020
Heavily transfused patients frequently develop human leukocyte antigen (HLA) allo‐immunization resulting in platelet transfusion refractoriness and a high risk for life‐threatening thrombocytopenia.
Vo P, Purev E, West KA, McDuffee E, Worthy T, Cook L, Hawks G, Wells B, Shalabi R, Flegel WA, Adams SD, Reger R, Aue G, Tian X, Childs R.   +14 more
europepmc   +2 more sources

Impact of platelet transfusion refractoriness in the first 30 days post-hematopoietic stem cell transplantation on outcomes of patients with myelodysplastic syndrome [PDF]

Frontiers in Immunology
Qiaoling Ma, Yuanfeng Zhang, Aiming Pang   +2 more
exaly   +2 more sources

Recognition and management of platelet-refractory bleeding in patients with Glanzmann’s thrombasthenia and other severe platelet function disorders

International Journal of General Medicine, 2017
Meera Chitlur,1 Madhvi Rajpurkar,1 Michael Recht,2 Michael D Tarantino,3 Donald L Yee,4 David L Cooper,5 Sriya Gunawardena5 1Carman and Ann Adams Department of Pediatrics, Wayne State University and Children’s Hospital of Michigan, Detroit, MI, USA;
Chitlur M, Rajpurkar M, Recht M, Tarantino MD, Yee DL, Cooper DL, Gunawardena S   +6 more
doaj   +1 more source

Efficacy of apheresis and concentrated platelets under different transfusion strategies

Zhongguo shuxue zazhi, 2022
Objective To retrospectively analyze the clinical effects of apheresis and concentrated platelets under different transfusion strategies, so as to explore more scientific transfusion strategies.
Meihong CHEN, Jiafu HUANG
doaj   +1 more source

Risk Factors of Platelet Refractoriness After Thrombocyte Concentrate Transfusion in Pediatric Acute Leukemia

, 2022
Children with acute leukemia often require platelet transfusions, but the platelet count frequently doesn't reach a satisfactory response, which is known as platelet refractoriness. This study aimed to analyze the risk factors for platelet refractoriness
Hosea, M. K. (Mellisa), Wardhani, A. N. (Adwina), Ugrasena, I. D. (I), Andarsini, M. R. (Mia), Larasati, M. C. (Maria), Cahyadi, A. (Andi)   +5 more
core   +2 more sources

Establishment and evaluation of predictive models of platelet transfusion effect in multi-center tumor patients

Zhongguo shuxue zazhi, 2023
Objective To study the platelet transfusion predictive models in tumor patients and evaluate its application effect. Methods A retrospective study was conducted on 944 tumor patients, including 533 males and 411 females who received platelet transfusion ...
Gang ZHAO, Fan GUO, Qing LI, Yihua XIE, Jun LI   +4 more
doaj   +1 more source

Factors affecting the efficacy of platelet transfusion and specificity of HLA-Ⅰ antibodies in tumor patients

Zhongguo shuxue zazhi, 2023
Objective To analyze the factors affecting the efficacy of platelet transfusion and the specificity of HLA-Ⅰ antibodies in tumor patients. Methods Tumer patients applied for platelet transfusion from November 2019 to July 2021 in Sichuan Cancer Hospital ...
Juan SAI, Shanshan WAN, Li TIAN
doaj   +1 more source

Platelet compatibility and platelet antibodies detection: A step towards resolving dilemma in management of platelet refractoriness in oncology patients

Global Journal of Transfusion Medicine, 2019
Background: Platelet refractoriness complicates the provision of platelet transfusions- a critical and essential part in management of thrombocytopenia in Oncology patients. Platelet refractoriness poses challenge due to alloimmunization to HLA (Class I)
Sadhana Mangwana, Atin Kacker, Nikhil Simon   +2 more
doaj   +1 more source