Platelet transfusion refractoriness [PDF]
British Journal of Haematology, 2008 SummaryThe platelet, a fascinating anucleate cell, is critically important for haemostasis. Platelet transfusions have greatly reduced the incidence of major haemorrhagic complications associated with the management of haematological and oncological disorders. However, some patients fail to receive the full benefit of platelet transfusions because they
Eldad, Hod, Joseph, Schwartz
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Prevalence of platelet reactive antibodies in patient′s refractory to platelet transfusions
Asian Journal of Transfusion Science, 2014 Introduction & Aims: Though platelet transfusions have greatly reduced the incidence of major haemorrhagic complications associated with the management of haematological and oncological disorders, refractoriness to infused platelets becomes a major ...
Nitin Agarwal +3 more
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Case Study: HLA incompatible platelet infusion to allow emergency salvage HCT in a patient with primary graft failure due to donor specific HLA antibody [PDF]
Frontiers in ImmunologyA patient with myelodysplasia received a haploidentical hematopoietic stem cell transplant (HCT). Pre-transplant HLA antibody screening showed no detectable donor-specific antibodies (DSAs). Post-transplant, the patient developed an anti-HLA-A2 antibody,
Louise Goddard +3 more
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Platelet alloimmunization in transfusion-dependent thalassemia patients from Southern China (2014-2023) [PDF]
Frontiers in ImmunologyPatients with transfusion-dependent thalassemia (TDT) are at high risk of alloimmunization. While previous research is predominantly focused on red blood cell alloimmunization, the potential risks of platelet alloimmunization are frequently ...
Yuchen Huang +10 more
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Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics
PlateletsAlthough there have been tremendous improvements in the production and storage of platelets, platelet transfusion refractoriness (PTR) remains a serious clinical issue that may lead to various severe adverse events.
Xiaoyu Chen +3 more
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Clinical and immunological features of platelet transfusion refractoriness in young patients with de novo acute myeloid leukemia. [PDF]
Cancer Med, 2020 Hu X +11 more
europepmc +2 more sources
Efficacy of apheresis and concentrated platelets under different transfusion strategies
Zhongguo shuxue zazhi, 2022 Objective To retrospectively analyze the clinical effects of apheresis and concentrated platelets under different transfusion strategies, so as to explore more scientific transfusion strategies.
Meihong CHEN, Jiafu HUANG
doaj +1 more source
Zhongguo shuxue zazhi, 2023 Objective To study the platelet transfusion predictive models in tumor patients and evaluate its application effect. Methods A retrospective study was conducted on 944 tumor patients, including 533 males and 411 females who received platelet transfusion ...
Gang ZHAO +4 more
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Platelet Biochemistry and Morphology after Cryopreservation [PDF]
, 2020 Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle +2 more
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Factors influencing transfusion-associated HLA sensitization in patients bridged to heart transplantation using ventricular assist device. [PDF]
, 2020 BackgroundBridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti-HLA antibodies associated with rejection of subsequent allografts ...
Adler, Eric +5 more
core +1 more source