Evaluation and management of platelet transfusion refractoriness [PDF]
Blood Research, 2022 Platelet transfusion refractoriness (PTR), in which platelet counts do not increase after transfusion, occurs in many patients receiving platelet transfusions. PTR is a clinical condition that can harm patients. The causes of PTR can be divided into two types: immune and non-immune. Most cases of PTR are non-immune. Among immune causes, the most common
Youk, Hee-Jeong +3 more
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Asian Journal of Transfusion Science, 2015 Background: This study was designed to determine the prevalence and assess the risk factors responsible for platelet transfusion refractoriness in hemato-oncological patients. Materials and Methods: The study included 30 patients.
Vijay Kumawat +3 more
doaj +2 more sources
A Practical and Efficient Multiplex qPCR Assay for Simultaneous Detection of HLA Cross-Reactive Groups and Human Platelet Antigens. [PDF]
J Clin Lab AnalThis assay enables multiplex genotyping of HLA‐CREGs and HPA alleles from whole blood using qPCR with an integrated parallel negative control. Results are interpreted based on amplification curves and Ct values, with validity dependent on strict quality control criteria for both the target reactions and the negative control.
Ji H +9 more
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Identification of platelet refractoriness in oncohematologic patients [PDF]
Clinics, 2011 OBJECTIVES: To identify the occurrence and the causes of platelet refractoriness in oncohematologic patients. INTRODUCTION: Platelet refractoriness (unsatisfactory post-transfusion platelet increment) is a severe problem that impairs the treatment of ...
Aline Aparecida Ferreira +4 more
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The use of splenectomy to manage platelet transfusion refractoriness due to anti-human leukocyte antibodies in allogeneic stem cell transplantation [PDF]
Pediatric Reports, 2016 In patients undergoing hematopoietic stem cell transplantation (HSCT), refractoriness to platelet transfusion has been associated with graft failure, delayed engraftment, early mortality and decreased overall survival.
Margherita Mauro +6 more
doaj +2 more sources
Severe platelet transfusion refractoriness after thoracoabdominal aneurysm repair [PDF]
Journal of Vascular Surgery Cases and Innovative TechniquesSevere thrombocytopenia after thoracoabdominal aortic aneurysm repair poses a significant clinical risk in the immediate postoperative period.
Claire M. Motyl, MD +3 more
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Zhongguo shuxue zazhi[Objective] To compare and analyze the efficacy of platelet transfusion in patients with different doses, and to analyze the risk factors for platelet transfusion refractoriness.
ZHU Jianling +5 more
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Prevalence and Specificity of Anti-HPA and Anti-HLA Antibodies in Patients with Suspected Immune-Mediated Platelet Disorders: A Single-Center Study from Serbia [PDF]
MedicinaBackground and Objectives: Alloantibodies directed against human platelet antigens and human leukocyte antigens are implicated in several immune-mediated platelet disorders, including platelet transfusion refractoriness, post-transfusion purpura and ...
Svetlana Vojvodić, Jasmina Grujić
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Research progress on prevention strategies for immune platelet transfusion refractoriness
Zhongguo shuxue zazhiPlatelet transfusion refractoriness (PTR) is a common issue among patients with hematological diseases and tumors. This article reviews the diagnostic criteria, influencing factors, and recent prevention and management strategies for immune PTR.
ZHAO Peizhe +5 more
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Platelet transfusion: basic aspects
Swiss Medical Weekly, 2013 Platelet transfusions have been shown to prevent major haemorrhage and improve survival in thrombocytopenic patients. Since then, advances in the preparation of platelet components, including the introduction of pathogen reduction techniques, have ...
Andreas Holbro +3 more
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