Avatrombopag for the salvage treatment of platelet transfusion refractoriness [PDF]
Therapeutic Advances in HematologyBackground: Platelet transfusion refractoriness (PTR) is a life-threatening and intractable condition in hematological patients. Thrombopoietin receptor agonists such as avatrombopag promote platelet production and modulate immune intolerance.
Yuehong Qin +4 more
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Extent of transfusion support in a developing country in managing a bleeding acute myeloid leukemia patient with platelet transfusion refractoriness [PDF]
Asian Journal of Transfusion Science, 2021 Conventional platelet transfusion may not be adequate to deal with platelet transfusion refractoriness (PTR), and therefore human leukocyte antigen (HLA) or human platelet antigen (HPA) matched and platelet crossmatch compatible units are recommended ...
Gayathiri K Chellaiya +5 more
doaj +2 more sources
Prevalence, Risk Factors, and Outcomes of Platelet Transfusion Refractoriness in Critically Ill Patients: A Retrospective Cohort Study [PDF]
Critical Care Research and Practice, 2021 Background. Refractoriness to platelet transfusion is an understudied phenomenon in critically ill patients. Our objective was to evaluate the prevalence, risk factors, and clinical outcomes of platelet refractoriness among patients in a tertiary-care ...
Saeed Arabi +5 more
doaj +2 more sources
Anti-HLA Class I alloantibodies in platelet transfusion refractoriness: From mechanisms and determinants to therapeutic prospects [PDF]
Frontiers in Immunology, 2023 Patients with hematological disorders and severe thrombocytopenia require extensive and iterative platelet transfusion support. In these patients, platelet transfusion refractoriness represents a serious adverse transfusion event with major outcomes for ...
Adèle Couvidou +15 more
doaj +2 more sources
Related donor platelet transfusion improves platelet transfusion refractoriness in hematological patients [PDF]
Frontiers in Medicine, 2023 ObjectiveTransfusion of HLA-matched platelets can reduce the effect of alloimmune responses on platelet transfusion efficacy; however, finding HLA-matched platelets in the population is nearly impossible. Almost all HLA-matched platelets from related are
Jing-Cheng Zhang +3 more
doaj +2 more sources
Severe platelet transfusion refractoriness after thoracoabdominal aneurysm repair [PDF]
Journal of Vascular Surgery Cases and Innovative TechniquesSevere thrombocytopenia after thoracoabdominal aortic aneurysm repair poses a significant clinical risk in the immediate postoperative period.
Claire M. Motyl, MD +3 more
doaj +2 more sources
Identification of platelet refractoriness in oncohematologic patients [PDF]
Clinics, 2011 OBJECTIVES: To identify the occurrence and the causes of platelet refractoriness in oncohematologic patients. INTRODUCTION: Platelet refractoriness (unsatisfactory post-transfusion platelet increment) is a severe problem that impairs the treatment of ...
Aline Aparecida Ferreira +4 more
doaj +2 more sources
The use of splenectomy to manage platelet transfusion refractoriness due to anti-human leukocyte antibodies in allogeneic stem cell transplantation [PDF]
Pediatric Reports, 2016 In patients undergoing hematopoietic stem cell transplantation (HSCT), refractoriness to platelet transfusion has been associated with graft failure, delayed engraftment, early mortality and decreased overall survival.
Margherita Mauro +6 more
doaj +2 more sources
Prevalence and Specificity of Anti-HPA and Anti-HLA Antibodies in Patients with Suspected Immune-Mediated Platelet Disorders: A Single-Center Study from Serbia [PDF]
MedicinaBackground and Objectives: Alloantibodies directed against human platelet antigens and human leukocyte antigens are implicated in several immune-mediated platelet disorders, including platelet transfusion refractoriness, post-transfusion purpura and ...
Svetlana Vojvodić, Jasmina Grujić
doaj +2 more sources
Platelet transfusion: basic aspects
Swiss Medical Weekly, 2013 Platelet transfusions have been shown to prevent major haemorrhage and improve survival in thrombocytopenic patients. Since then, advances in the preparation of platelet components, including the introduction of pathogen reduction techniques, have ...
Andreas Holbro +3 more
doaj +2 more sources