Results 41 to 50 of about 8,497,511 (124)

TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression

Cell Death and Disease, 2021
Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM) and the dysfunction of Schwann cells plays an important role in the pathogenesis of DPN.
Xiang Zhang, Song Zhao, Qingqing Yuan, Lin Zhu, Fan Li, Hui Wang, D. Kong, Jun Hao   +7 more
semanticscholar   +1 more source

Transit-amplifying cells coordinate changes in intestinal epithelial cell type composition

Developmental Cell, 2021
Summary Renewing tissues have the remarkable ability to continually produce both proliferative progenitor and specialized differentiated cell types.
L. Sanman, Ina W. Chen, Jake M. Bieber, V. Steri, Coralie Trentesaux, B. Hann, Ophir D. Klein, La-Ni F. Wu, S. Altschuler   +8 more
semanticscholar   +1 more source

The DNA Damage Checkpoint in Embryonic Cell Cycles Is Dependent on the DNA-to-Cytoplasmic Ratio

, 2004
In Xenopus, cell cycle checkpoints monitoring DNA damage, DNA replication, and spindle assembly do not appear until after the midblastula transition (MBT; 4000 cells).
Lewellyn, Andrea L., Conn, Christopher W., Maller, James L.   +2 more
core   +1 more source

Metabolic trade-offs constrain the cell size ratio in a nitrogen-fixing symbiosis.

Cell
Biological dinitrogen (N2) fixation is a key metabolic process exclusively performed by prokaryotes, some of which are symbiotic with eukaryotes.
F. Cornejo-Castillo, Keisuke Inomura, J. Zehr, M. Follows   +3 more
semanticscholar   +1 more source

Post treatment NLR is a predictor of response to immune checkpoint inhibitor therapy in patients with esophageal squamous cell carcinoma

Cancer Cell International, 2021
In view of the fact that peripheral blood parameters have been reported as predictors of immunotherapy to various cancers, this study aimed to determine the predictors of response to anti-programmed death-1 (anti-PD-1) therapy in patients with esophageal
Xianbin Wu, Run-Kun Han, Y. Zhong, Nuoqing Weng, Ao Zhang   +4 more
semanticscholar   +1 more source

RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. [PDF]

, 2017
RhoA-mediated regulation of myosin-II activity in the actin cortex controls the ability of cells to contract and bleb during a variety of cellular processes, including cell migration and division.
Valderrama, F, Ferran Valderrama, Michael Way, Yutaka Handa, Handa, Y, Way, Michael, Cordeiro, JV, Flavia Leite, Valderrama, Ferran, Way, M, Handa, Yutaka, Charlotte H. Durkin, Arakawa, Yoshiki, Durkin, CH, Cordeiro, João V, João V. Cordeiro, Leite, Flavia, Durkin, Charlotte H, Yoshiki Arakawa, Leite, F, Arakawa, Y   +20 more
core   +1 more source

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

, 2022
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma.
Raine, K, Yates, LR, Teague, J, Lopez, JI, Gore, M, Rowan, A, Mitchell, TJ, Lynch, AG, Au, L, Stewart, A, Litchfield, K, Turajlic, S, Tarpey, P, Chandra, A, Csabai, I, Swanton, C, Fotiadis, N, Lynch, J, Soultati, A, Challacombe, B, Xu, H, Hazell, S, Stamp, G, Elaidi, R, Horswell, S, Campbell, PJ, Chowdhury, S, Butler, AP, Rudman, S, Wedge, DC, Futreal, PA, Nicol, D, Farmery, JHR, O'Brien, T, Maura, F, McGranahan, N, TRACERx Renal Consortium,, Spain, L, Stewart, GD, Szallasi, Z, Martincorena, I, Stares, M, Fernando, A, Larkin, J, Oudard, S, Pickering, L, Chambers, T, Angelopoulos, N   +47 more
core   +1 more source

PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer

Cell Death and Disease
Abnormal epigenetic modifications are involved in the regulation of Warburg effect in tumor cells. Protein arginine methyltransferases (PRMTs) mediate arginine methylation and have critical functions in cellular responses.
Lu Peng, Yujiao Zhao, Jiang Tan, Jingyao Hou, Xin Jin, Dong-Xu Liu, Bai-Qu Huang, Jun Lu   +7 more
semanticscholar   +1 more source

Stem Cell States, Fates, and the Rules of Attraction

, 2009
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different ...
Andrews, Peter W., Peterson, Carsten, Enver, Tariq, Pera, Martin, Peterson, Carsten,   +4 more
core   +1 more source

Bax/Bcl-2 Ratio as the Golden Marker of Apoptosis: Molecular Mechanisms and Regulatory Pathways

International Journal of Cell and Biomedical Science
Apoptosis is an essential biological mechanism responsible for maintaining tissue homeostasis by removing unnecessary or damaged cells. Among the key molecular regulators, the interplay between the pro-apoptotic protein Bax and the anti-apoptotic protein
Ghea Farmaning Thias Putri, Zahara Nurfatihah Z   +1 more
semanticscholar   +1 more source