Results 51 to 60 of about 8,497,511 (124)

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

, 2019
International audienceStromal cell populations that maintain hematopoietic stem and progenitor cells (HSPCs) are generally characterized in steady-state conditions.
Scadden, David, Scadden, Elizabeth, Rhee, Catherine, Kfoury, Youmna, Karabacak, Nezihi Murat, Brouse, Thomas, Baryawno, Ninib, Courties, Gabriel, Nahrendorf, Matthias, Lee, Dongjun, Severe, Nicolas, Gustafsson, Karin, Toner, Mehmet, Kokkaliaris, Konstantinos, Garcia-Robledo, Juan Esteban, Kfoury, Y, Courties, G, Lee, D, Gustafsson, K, Baryawno, N,, Scadden, EW, Rhee, C, Severe, N, Karabacak, NM, Kokkaliaris, KD   +24 more
core   +1 more source

Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Cell Discovery
Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive.
Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-Xin Yang, Zhen-Zhen Ma, Lin Huang, Yan-Peng An, Yi-Yuan Yuan, Yan Lin, Wei Xu, Yao Li, Peng-Cheng Lin, Jing Cao, Jian-Yuan Zhao, Shi-min Zhao   +14 more
semanticscholar   +1 more source

Sensors of Succinate : Neural Stem Cell Grafts Fight Neuroinflammation

, 2018
In this issue of Cell Stem Cell, Peruzzotti-Jametti et al. (2018) demonstrate how neural stem cells, transplanted in a mouse model of multiple sclerosis, respond to extracellular succinate and modulate neuroinflammation by releasing anti-inflammatory ...
Olle Lindvall, Kokaia, Zaal, Zaal Kokaia, Lindvall, Olle, Kokaia, Zaal,, Lindvall, Olle,, Lund University.   +6 more
core   +1 more source

MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway

Stem cell research & therapeutics, 2021
Background Expansion-mediated replicative senescence and age-related natural senescence have adverse effects on mesenchymal stem cell (MSC) regenerative capability and functionality, thus severely impairing the extensive applications of MSC-based ...
Chen-Chen Pi, Cao Ma, Huan Wang, Huiyan Sun, Xiao Yu, Xingyu Gao, Yue Yang, Yanan Sun, Haiying Zhang, Ying-ai Shi, Yan Li, Yu-Lin Li, Xu He   +12 more
semanticscholar   +1 more source

Bringing the genetically minimal cell to life on a computer in 4D.

Cell
We present a whole-cell spatial and kinetic model for the ∼100 min cell cycle of the genetically minimal bacterium JCVI-syn3A. We simulate the complete cell cycle in 4D (space and time), including all genetic information processes, metabolic networks ...
Zane R. Thornburg, Andrew K. Maytin, Jiwoong Kwon, Troy A. Brier, Benjamin R. Gilbert, En-Guang Fu, Yang-Le Gao, Jordan Quenneville, Tian-Yu Wu, Henry Li, Talia Long, W. Pezeshkian, Lijie Sun, John I. Glass, Angad P. Mehta, T. Ha, Z. Luthey-Schulten   +16 more
semanticscholar   +1 more source

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Cell, 2019
Summary Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important remains poorly understood.
Gabriel E. Neurohr, R. L. Terry, Jette Lengefeld, Megan E. Bonney, G. Brittingham, Fabien Moretto, Teemu P. Miettinen, L. P. Vaites, L. M. Soares, João A. Paulo, J. Harper, S. Buratowski, S. Manalis, F. V. van Werven, L. Holt, Angelika Amon   +15 more
semanticscholar   +1 more source

Planar cell polarity protein Celsr1 regulates endothelial adherens junctionsand directed cell rearrangements during lymphatic valve morphogenesis.

, 2013
Planar cell polarity (PCP) signaling controls tissue morphogenesis by coordinating collective cell behaviours. Here we show a critical role for the core PCP proteins Celsr1 and Vangl2 in the complex morphogenetic process of intraluminal valve formation ...
Devenport, Danelle, Weston, Anne, Taddei, Andrea, Makinen, Taija, Mäkinen, Taija,, Davenport, Danelle, Fuchs, Elaine, Tatin, Florence, Tissir, Fadel   +8 more
core   +1 more source

Identifiability and privacy in pluripotent stem cell research [PDF]

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Burton, Paul, Lomax, G, Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM, Baltz, Jay M., Andrews, Peter W., Ng, Huck Hui, Stacey, Glyn N., Bredenoord, Annelien L., Knoppers, Bartha Maria, Hull, Sara Chandros   +44 more
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RNA:protein ratio of the unicellular organism as a characteristic of phosphorous and nitrogen stoichiometry and of the cellular requirement of ribosomes for protein synthesis [PDF]

, 2006
Background Mean phosphorous:nitrogen (P:N) ratios and relationships of P:N ratios with the growth rate of organisms indicate a surprising similarity among and within microbial species, plants, and insect herbivores.
Karpinets, Tatiana V., Greenwood, Duncan J., Greenwood Duncan J, Sams Carl E, Greenwood , Duncan J., Ammons John T, Sams, Carl E., Ammons, John T., Karpinets Tatiana V, John T Ammons, Carl E Sams, Tatiana V Karpinets, Duncan J Greenwood   +12 more
core   +1 more source

A genetic basis for sex differences in Xp11 translocation renal cell carcinoma

Cell
Summary: Xp11 translocation renal cell carcinoma is a rare, female-predominant cancer driven by a fusion between the TFE3 gene on chromosome Xp11.2 and a partner gene on either chrX or an autosome. It remains unknown what types of rearrangements underlie
M. Achom, Ananthan Sadagopan, Chunyang Bao, Fiona McBride, Jiao Li, Prathyusha Konda, R. Tourdot, Qingru Xu, Maria Nakhoul, Daniel S. Gallant, Usman Ali Ahmed, J. O'Toole, Dory A Freeman, G. M. Lee, Jonathan L. Hecht, Eric C. Kauffman, David J. Einstein, T. Choueiri, Cheng-Zhong Zhang, S. Viswanathan   +19 more
semanticscholar   +1 more source