Results 71 to 80 of about 8,497,511 (124)

Material Cues as Potent Regulators of Epigenetics and Stem Cell Function [PDF]

, 2015
Biophysical signals act as potent regulators of stem cell function, lineage commitment, and epigenetic status. In recent years, synthetic biomaterials have been used to study a wide range of outside-in signaling events, and it is now well appreciated ...
Whitaker, T, Papathanasiou, P, Stevens, MM, Crowder, SW, Leonardo, V   +4 more
core   +1 more source

Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma

Cell Death and Disease, 2019
Recent studies showed that lncRNA CASC9 was upregulated and acted as an oncogene in a variety of tumors. However, the expression and biological functions of CASC9 in oral squamous cell carcinoma (OSCC) remain unknown.
Yi-Xing Yang, Dan Chen, Huan Liu, Kai Yang   +3 more
semanticscholar   +1 more source

Implications of perioperative allogeneic red blood cell transfusion on the immune-inflammatory response

Hematology, Transfusion and Cell Therapy, 2020
Background The allogeneic transfusion-related immunomodulation (TRIM) may be responsible for an increase in survival of renal transplants but in contrast it could increase the rate of bacterial infections or the recurrence rate of tumors post-operatively.
J. E. Aguilar-Nascimento, José Pedro Zampieri-Filho, J. Bordin   +2 more
semanticscholar   +1 more source

USP9X Enhances the Polarity and Self-Renewal of Embryonic Stem Cell-derived Neural Progenitors

, 2009
The substrate-specific deubiquitylating enzyme USP9X is a putative “stemness” gene expressed in many progenitor cell populations. To test its function in embryonic stem cell-derived neural progenitor/stem cells, we expressed USP9X from a Nestin promoter.
Taylor, V., Jolly, Lachlan A, Wood, S., Taylor, Verdon, Wood, Stephen A, Jolly, L.   +5 more
core   +1 more source

Modelling cell movement, cell differentiation, cell sorting and proportion regulation in Dictyostelium discoideum aggregations [PDF]

, 2015
Understanding the mechanisms that control tissue morphogenesis and homeostasis is a central goal not only in developmental biology but also has great relevance for our understanding of various diseases, including cancer.
Weijer, C. J.; id_orcid, Pineda, M., Eftimie, R.   +2 more
core   +1 more source

The nuclear-cytoplasmic ratio controls the cell-cycle period in compartmentalized frog egg extract [PDF]

Each proliferating cell replicates its DNA and internal components before distributing this material evenly to its daughters. Although the regulation of cyclin-dependent kinases (Cdks) that dictate orderly cell-cycle progression is well characterized ...
Ruiz-Reynés, Daniel, Cavin-Meza, Gabriel, Piñeros, Liliana, Frolov, Nikita, Van Eynde, Aleyde, Heald, Rebecca, Gelens, Lendert, Ruiz Reynés, Daniel   +7 more
core   +1 more source

β-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma

Cell Death and Disease, 2019
Hepatocellular carcinoma (HCC), a common liver malignancy worldwide, has high morbidity and mortality. β-Thujaplicin, a tropolone derivative, has been used in some health-care products and clinical adjuvant drugs, but its use for HCC is unknown.
Guang-Ya Zhang, Jiangping He, Xiao-Fei Ye, Jing Zhu, Xi Hu, Minyan Shen, Yuru Ma, Ziming Mao, Huai-Dong Song, Feng-Ling Chen   +9 more
semanticscholar   +1 more source

Relative Rates of Surface and Volume Synthesis Set Bacterial Cell Size

Cell, 2016
Summary Many studies have focused on the mechanisms underlying length and width determination in rod-shaped bacteria. Here, we focus instead on cell surface area to volume ratio (SA/V), and demonstrate that SA/V homeostasis underlies size determination ...
Leigh K. Harris, J. Theriot
semanticscholar   +1 more source

Pathological significance and prognostic roles of densities of CD57+ cells, CD68+ cells, and mast cells, and their ratios in clear cell renal cell carcinoma [PDF]

, 2018
The immune system is closely associated with malignant behavior in renal cell carcinoma (RCC). Therefore, understanding the pathological roles of immune cells in tumor stroma is essential to discuss the pathological characteristics of RCC. In this study,
Tomohiro Matsuo, Ohba, Kojiro, Yuichiro Nakamura, Hiromi Nakanishi, Yuji Sagara, Takuji Yasuda, Kyohei Araki, Miyata, Yasuyoshi, Sakai, Hideki, Yasuyoshi Miyata, Araki, Kyohei, Mochizuki, Yasushi, Matsuo, Tomohiro, Nakanishi, Hiromi, Nakamura, Yuichiro, Yasushi Mochizuki, Sagara, Yuji, Kojiro Ohba, Yasuda, Takuji, 中西, 裕美, Hideki Sakai   +20 more
core   +1 more source

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

Nature Cell Biology, 2017
Adult and fetal haematopoietic stem cells (HSCs) display a glycolytic phenotype, which is required for maintenance of stemness; however, whether mitochondrial respiration is required to maintain HSC function is not known.
Elena Ansó, S. Weinberg, Lauren P. Diebold, B. Thompson, S. Malinge, P. Schumacker, Xin Liu, Yuannyu Zhang, Zhen Shao, Mya Steadman, Kelly Marsh, Jian Xu, J. Crispino, N. Chandel   +13 more
semanticscholar   +1 more source