Results 81 to 90 of about 8,497,511 (124)

Largen: A Molecular Regulator of Mammalian Cell Size Control [PDF]

, 2014
Little is known about how mammalian cells maintain cell size homeostasis. We conducted a novel genetic screen to identify cell-size-controlling genes and isolated Largen, the product of a gene (PRR16) that increased cell size upon overexpression in human
Gandin, Valentina, Li, Wanda, Inoue, Satoshi, Itsumi, Momoe, Silvester, Jennifer Liepa, Shahinian, Arda, Wakeham, Andrew, Lapin, Valentina, Mullen, Peter J., Haight, Jillian, Wang, Feng, Mak, Tak W., Yamamoto, Kazuo, Topisirovic, Ivan, McCracken, Susan, Sasaki, Masato, Sonenberg, Nahum, Oo, Yathor D, Elia, Andrew J., Alexandrova, Roumiana, Ikura, Mitsuhiko, Wakutani, Yosuke, Oo, Yathor D.   +22 more
core   +1 more source

Hematopoietic stem cell responsiveness to exogenous signals is limited by Caspase-3

, 2008
SummaryLimited responsiveness to inflammatory cytokines is a feature of adult hematopoietic stem cells and contributes to the relative quiescence and durability of the stem cell population in vivo.
Riese, Matthew J, Woo, Minna, Karlsson, Göran, Milne, Craig D, Lo Celso, Cristina, Karlsson, Göran,, Scadden, David T, Fleming, Heather E, Paige, Christopher J, Karlsson, Stefan, Janzen, Viktor, Reynolds, Griffin, Karlsson, Stefan,, Riedt, Tamara, Lund University.   +14 more
core   +1 more source

The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin [PDF]

, 2004
Copyright © 2004 by The American Society for Cell Biology.Ubiquitylation is a necessary step in the endocytosis and lysosomal trafficking of many plasma membrane proteins and can also influence protein trafficking in the biosynthetic pathway.
Murray, Rachael, Murray, RZ, Wood, S., Wood, SA, Wood, Stephen J., Jolly, LA, Jolly, Lachlan, Murray, R., Jolly, L.   +8 more
core   +2 more sources

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

, 2023
Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure.
Parashar Dhapola, Säwén, Petter, Karlsson, Göran, Anna Konturek-Ciesla, David Bryder, Wan, Haixia, Göran Karlsson, Bryder, David, Haixia Wan, Qinyu Zhang, Petter Säwén, Zhang, Qinyu, Konturek-Ciesla, Anna, Dhapola, Parashar, Dhapola, Parashar,, Karlsson, Göran,, Bryder, David,, Wan, Haixia,, Zhang, Qinyu,, Säwén, Petter,, Konturek-Ciesla, Anna,, Lund University.   +21 more
core   +1 more source

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

Cell Metabolism, 2016
Summary Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. While metformin can act cell autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue ...
Dan Y. Gui, Lucas B. Sullivan, Alba Luengo, Aaron M. Hosios, Lauren N. Bush, Nadege Gitego, Shawn M. Davidson, E. Freinkman, C. Thomas, M. V. Vander Heiden   +9 more
semanticscholar   +1 more source

Why is it taking so long to develop clinically competitive stem cell therapies for CNS disorders?

, 2012
The remarkable advancements in basic stem cell research with implications for several central nervous system disorders have so far not been translated into clinically effective therapies.
Lindvall, Olle, Lindvall, Olle,, Lund University.   +2 more
core   +1 more source

Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease : Dawn of a New Era [PDF]

, 2017
Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons.
Roger A. Barker, Barker, Roger A., Parmar, Malin, Takahashi, Jun, Jun Takahashi, Malin Parmar, Lorenz Studer, Studer, Lorenz, Studer, Lorenz,, Parmar, Malin,, Takahashi, Jun,, Lund University., Barker, Roger A.,   +12 more
core   +2 more sources

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

, 2011
SummarySomatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age.
Sigvardsson, Mikael,, Norddahl, Gudmundur L,, Wahlestedt, Martin, Sigvardsson, Mikael, Gudmundur L. Norddahl, Sten, Gerd, Mikael Sigvardsson, Pronk, Kees-Jan, Martin Wahlestedt, Cornelis J. Pronk, Norddahl, Gudmundur, Norddahl, Gudmundur L.,, Wahlestedt, Martin,, David Bryder, Nygren, Jens, Sten, Gerd,, Bryder, David,, Ugale, Amol, Pronk, Cornelis J,, Nygren, Jens M,, Jens M. Nygren, Bryder, David, Amol Ugale, Pronk, Cornelis J.,, Nygren, Jens M.,, Ugale, Amol,, Gerd Sten, Pronk, Kees-Jan,, Norddahl, Gudmundur,, Nygren, Jens,, Lund University.   +30 more
core   +1 more source

Smarandache's ratio theorem [PDF]

, 2010
In this paper we present the Smarandache's ratio theorem in the geometry of the ...
Khoshnevisan, M.
core   +1 more source

Co-development of Mesoderm and Endoderm Enables Organotypic Vascularization in Lung and Gut Organoids

Cell
Summary The vasculature and mesenchyme exhibit distinct organ-specific characteristics adapted to local physiological needs, shaped by microenvironmental and cell-cell interactions from early development.
Yi-Fei Miao, Nicole M. Pek, Cheng Tan, Cheng Jiang, Zhiyun Yu, K. Iwasawa, Min Shi, Daniel O. Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Debora Sinner, Xing-Chen Liu, Ko-Chih Lin, C. Na, Keishi Kishimoto, Min-Chia Yang, S. Maharjan, J. Tchieu, Jeffrey A. Whitsett, Y. Zhang, K. McCracken, R. Rottier, D. Kotton, M. Helmrath, James M. Wells, Takanori Takebe, Aaron M. Zorn, Ya-Wen Chen, M. Guo, Ming-Xia Gu   +29 more
semanticscholar   +1 more source