Results 61 to 70 of about 8,497,511 (124)

The male to female ratio at birth [PDF]

, 2014
The factors that influence the male to female ratio at birth are legion. Males are usually born in excess and stress decreases the ratio while wellbeing and good health tends to increase it.
Mamo, Julian, Grech, Victor E.
core   +1 more source

SLC25A51 Decouples the Mitochondrial NAD+/NADH Ratio to Control Proliferation of AML Cells

Cell Metabolism
Summary SLC25A51 selectively imports oxidized NAD+ into the mitochondrial matrix and is required for sustaining cell respiration. We observed elevated expression of SLC25A51 that correlated with poorer outcomes in patients with Acute Myeloid Leukemia ...
Mu-Jie Lu, Jonathan Busquets, Valeria Impedovo, Crystal N. Wilson, Hsin-Ru Chan, Yu-Tai Chang, William Matsui, S. Tiziani, Xiaolu A. Cambronne   +8 more
semanticscholar   +1 more source

Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution.

Cell Reports, 2021
In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements.
Mengqing Gao, Jin Wang, S. Rousseaux, Min-Jia Tan, Lulu Pan, Lijun Peng, Sisi Wang, Wenqian Xu, Jiayi Ren, Yuan-Fang Liu, M. Spinck, Sophie Barral, Tao Wang, F. Chuffart, E. Bourova-Flin, D. Puthier, S. Curtet, Lisa Bargier, Zhong-Yi Cheng, H. Neumann, Jian Li, Ying-Ming Zhao, Jian-Qing Mi, S. Khochbin   +23 more
semanticscholar   +1 more source

The relationship between perimeter ratio, R, and cell cluster size obtained from cancer cell-implanted blood.

, 2014
The relationship between perimeter ratio, R, and cell cluster size obtained from cancer cell-implanted blood.
Yoshiyasu Nakamura (482104), Hyonchol Kim (312802), Tokuzo Arao (150793), Yohei Miyagi (153395), Mathias Girault (618731), Masao Odaka (618730), Kazuko Sakai (411763), Kazuto Nishio (150795), Akihiro Hattori (312805), Kenji Yasuda (312813), Hideyuki Terazono (312800)   +10 more
core   +1 more source

HIF1α-dependent uncoupling of glycolysis suppresses tumor cell proliferation

Cell Reports
Summary Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. However, lower glycolysis is compromised in human clear cell renal cell carcinomas, in which HIF1α acts as a tumor suppressor by inhibiting cell ...
Andrés A. Urrutia, Claudia Mesa-Ciller, Andrea Guajardo-Grence, H. F. Alkan, Ines Soro-Arnaiz, A. Vandekeere, Ana Margarida Ferreira Campos, S. Igelmann, Lucía Fernández-Arroyo, Gianmarco Rinaldi, Doriane Lorendeau, K. de Bock, S. Fendt, J. Aragonés   +13 more
semanticscholar   +1 more source

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages

, 2017
Stem cell engineering and grafting of mesencephalic dopamine (mesDA) neurons is a promising strategy for brain repair in Parkinson's disease (PD). Refinement of differentiation protocols to optimize this approach will require deeper understanding of ...
Perlmann, Thomas,, Storvall, Helena,, Gillberg, L, Perlmann, Thomas., Joodmardi, Eliza, Kirkeby, A, Gillberg, Linda,, Parmar, Malin,, Kirkeby, Agnete, Perlmann, Thomas, Lahti, Laura,, Sandberg, Rickard,, Nolbrant, Sara, Dahl, Lina,, Bjorklund, AK, Kee, N,, Storvall, H, Dahl, L, Kee, Nigel, Lahti, L, Björklund, Åsa K., Volakakis, Nikolaos, Kee, Nigel,, Dahl, Lina, Joodmardi, E, Parmar, Malin, Volakakis, N, Björklund, Åsa K.,, Bjoerklund, Aasa K., Joodmardi, Eliza,, Gillberg, Linda, Lahti, Laura, Storvall, Helena, Volakakis, Nikolaos,, Nolbrant, Sara,, Sandberg, Rickard, Nolbrant, S, Kirkeby, Agnete,, Lund University.   +38 more
core   +1 more source

The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory.

Cell Reports, 2020
Memory B cells (MBCs) epitomize the adaptation of the immune system to the environment. We identify two MBC subsets in peripheral blood, CD27dull and CD27bright MBCs, whose frequency changes with age.
O. Grimsholm, Eva Piano Mortari, A. Davydov, M. Shugay, A. Obraztsova, C. Bocci, E. Marasco, V. Marcellini, A. Aranburu, C. Farroni, D. Silvestris, C. Cristofoletti, E. Giorda, M. Scarsella, S. Cascioli, S. Barresi, V. Lougaris, A. Plebani, C. Cancrini, A. Finocchi, V. Moschese, D. Valentini, C. Vallone, F. Signore, G. D. de Vincentiis, S. Zaffina, G. Russo, A. Gallo, F. Locatelli, A. Tozzi, M. Tartaglia, D. Chudakov, R. Carsetti   +32 more
semanticscholar   +1 more source

maxATAC “pan-cell-type, peak-centric” training approach.

, 2023
(A) A small subset of our benchmark (11 TFs) was used to test peak-centric, pan-cell training (Methods) in a held-out cell type, GM12878. We varied the relative ratio of random and peak-centric regions ("Random Ratio") sampled during model training ...
Anthony T. Bejjani (14526729), Leah C. Kottyan (10954723), Artem Barski (76052), Matthew T. Weirauch (8154609), Joseph A. Wayman (5517764), Sreeja Parameswaran (6986009), Omer Donmez (10954720), V. B. Surya Prasath (4490002), Balaji Iyer (14526723), Benjamin Wronowski (3494882), Faiz W. Rizvi (14526720), Emily R. Miraldi (14526732), Michael Kotliar (14526726), Tareian A. Cazares (14526717), Xiaoting Chen (4113034)   +14 more
core   +1 more source

Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling

Cell Communication and Signaling, 2019
Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes.
Heike Reeh, Nadine Rudolph, Ulrike Billing, Henrike Christen, S. Streif, E. Bullinger, Monica Schliemann-Bullinger, R. Findeisen, F. Schaper, H. Huber, A. Dittrich   +10 more
semanticscholar   +1 more source

Post-Synapse Model Cell for Synaptic Glutamate Receptor (GluR)-Based Biosensing: Strategy and Engineering to Maximize Ligand-Gated Ion-Flux Achieving High Signal-to-Noise Ratio

, 2012
Cell-based biosensing is a “smart” way to obtain efficacy-information on the effect of applied chemical on cellular biological cascade. We have proposed an engineered post-synapse model cell-based biosensors to investigate the effects of chemicals on ...
Satoshi Migita, Akito Tateishi, Sarah K. Coleman, Kari Keinänen, Tetsuya Haruyama   +4 more
core   +1 more source