Results 21 to 30 of about 1,117,967 (288)

Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets

Platelets, 2022
Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively.
Carol Dangelmaier, Satya P Kunapuli
doaj   +1 more source

Avatrombopag improves thrombocytopenia in MYH9-related disorder following eltrombopag treatment failure

Platelets, 2022
MYH9-related disorder (MYH9-RD) is autosomal dominant thrombocytopenia caused by mutations in the MYH9 gene, which codes for the non-muscle myosin-IIA heavy chain. We present a case of a 24-year-old Chinese man with MYH9-RD who was initially misdiagnosed
Abdul Rehman Arif, Miaomiao Zhao, Wenlan Chen, Mei Xue, Shanshan Luo, Yadan Wang   +5 more
doaj   +1 more source

Differential expression of exosomal microRNAs in fresh and senescent apheresis platelet concentrates

Platelets, 2022
Patients have a high risk of suffering adverse reactions after receiving platelet products stored for 5 days. Bioactive exosomes in platelet products can be accumulated during storage, which is associated with adverse reactions.
Ziyue Mi, Li Gong, Yujie Kong, Peizhe Zhao, Yonghua Yin, Haixia Xu, Li Tian, Zhong Liu   +7 more
doaj   +1 more source

Sex-specific relationship between blood selenium levels and platelet count in a large cohort representative of the United States population

Platelets, 2022
While several small studies have found that selenium deficiency is associated with low platelet counts, they lack generalizability. We used data from the National Health and Nutrition Examination Surveys collected over a 12-year period.
Neda Rehan, Rehan Qayyum
doaj   +1 more source

Gender-related differences in changes of estimated bleeding risk in patients on dual antiplatelet therapy: the RE-SCORE multicenter prospective registry

Platelets, 2022
The risk of bleeding as predicted by the PRECISE-DAPT score can vary over time after percutaneous coronary intervention (PCI). We sought to compare the predictive ability of the PRECISE-DAPT score calculated at baseline and reassessed during follow-up in
Francesco Pelliccia, Felice Gragnano, Vincenzo Pasceri, Giuseppe Marazzi, Luca Cacciotti, Attilio Placanica, Giampaolo Niccoli, Tullio Palmerini, Giulio Speciale, Antonino Granatelli, Paolo Calabrò   +10 more
doaj   +1 more source

Diagnostic and prognostic role of platelets in patients with sepsis and septic shock

Platelets, 2023
Studies investigating the prognostic role of platelets commonly include critically ill patients, whereas data regarding the prognostic impact of platelet count in patients admitted with sepsis and septic shock is limited.
Tobias Schupp, Kathrin Weidner, Jonas Rusnak, Schanas Jawhar, Jan Forner, Floriana Dulatahu, Lea Marie Brück, Ursula Hoffmann, Maximilian Kittel, Thomas Bertsch, Ibrahim Akin, Michael Behnes   +11 more
doaj   +1 more source

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.

Journal of the American Medical Association (JAMA), 2015
IMPORTANCE Severely injured patients experiencing hemorrhagic shock often require massive transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red blood cells), defined as damage control resuscitation, has been ...
J. Holcomb, B. Tilley, S. Baraniuk, E. Fox, C. Wade, J. Podbielski, D. D. del Junco, K. Brasel, E. Bulger, R. Callcut, M. Cohen, B. Cotton, T. Fabian, K. Inaba, J. Kerby, P. Muškát, T. O'keeffe, S. Rizoli, B. Robinson, T. Scalea, M. Schreiber, D. Stein, J. Weinberg, J. Callum, J. Hess, N. Matijevic, Christopher N. Miller, J. Pittet, D. Hoyt, G. Pearson, B. Leroux, G. van Belle   +31 more
semanticscholar   +1 more source

Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib

Platelets, 2023
Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target ...
Nichola Cooper, Waleed Ghanima, Quentin A Hill, Phillip LR Nicolson, Vadim Markovtsov, Craig Kessler   +5 more
doaj   +1 more source

Platelet index on admission as a predictor of bacteremia in acute cholangitis: a 7-year retrospective observational study

Platelets, 2022
Bacteremia frequently occurs in patients with acute cholangitis, which could increase the risk of mortality. This single-center retrospective observational study was conducted from July 2013 to July 2020 to evaluate the predictive value of platelet index
XiaoYing Chen, Fu Wei, Dan Zhang, Shijing Tian   +3 more
doaj   +1 more source

Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial

Platelets, 2022
Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown.
Talia Falcão Dalçóquio, Mayara Alves dos Santos, Leandro Silva Alves, Flávia Bittar Brito Arantes, Larissa Ferreira-Santos, Maria Urbana Pinto Brandão Rondon, Remo Holanda M Furtado, Aline Gehlen Ferrari, Paulo Roberto Genestreti Rizzo, Rocio Salsoso, Andre Franci, Luciano Moreira Baracioli, Maria Janieire de Nazare Nunes Alves, Carlos Eduardo Negrão, José Carlos Nicolau   +14 more
doaj   +1 more source